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GlossaryAlbinism

genetic condition causing lack of melanin, leading to light skin

Albinism is a genetic condition characterized by a lack of melanin, the pigment responsible for coloring the skin, hair, and eyes. This results in very light skin, white or light-colored hair, and vision problems. Albinism can affect people of all ethnic backgrounds and is often associated with increased sensitivity to sunlight and a higher risk of skin cancer.

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community Eliminate/Confirm AGA based on blood report

in General 126 upvotes 9 months ago

A 19-year-old male with no family history of androgenetic alopecia (AGA) is experiencing hair loss and considering using a topical minoxidil and finasteride mixture. Despite low vitamin D levels and normal DHT serum levels, he seeks confirmation of AGA before starting treatment.

community Hair repigmentation of poliosis circumscripta in androgenetic alopecia patient treated with exosomes and fractional picosecond laser

in Product 2 upvotes 2 years ago

Exosomes combined with fractional picosecond laser treatment were effective in treating androgenetic alopecia and promoting repigmentation in white hair patches. The role of exosomes in hair repigmentation, particularly in conditions like poliosis, is not well-studied.

community 0.25 alfatradiol or 0.5 Pyrulitamide ?

in Product 4 upvotes 6 months ago

The conversation is about choosing an anti-androgen for hair loss treatment, with options being alfatradiol and pyrilutamide. Alfatradiol is considered a better choice due to its established use, while pyrilutamide is more experimental.

community Allopregnanolone deficiency by 5-ari inhibition (fin/dut users)

in Finasteride/Dutasteride 11 upvotes 2 years ago

The conversation is about managing allopregnanolone deficiency caused by 5-alpha-reductase inhibitors like finasteride or dutasteride. Specific treatments discussed for hair loss include Minoxidil, finasteride, and RU58841.

community Pp405 phase 2a clinical results

in Research/Science 38 upvotes 9 months ago

PP405 shows initial promise for treating androgenetic alopecia, with safety confirmed in early trials, but skepticism remains due to limited data. Further trials are needed to determine its true efficacy and potential market impact.

community Alfatradiol causing shedding ?

in Treatment 1 upvotes 1 year ago

The user experienced a sudden decrease in hair density after starting alfatradiol while already using finasteride. Another user mentioned that initial shedding can occur with hair loss treatments, but it may not last long.

community Alfatradiol only for mild thinning

in Product 1 upvotes 5 months ago

Alfatradiol is considered safe but less effective than finasteride for hair loss. One user reported subtle regrowth using alfatradiol with finasteride and minoxidil, while another found alfatradiol ineffective.

community May have been mis-diagnosed for 10 years, self-investigation into AGA + AA Incognita (Defused Shedding)

in Treatment 1 upvotes 1 year ago

A 27-year-old male with AGA and diffused thinning has been using oral Minoxidil, Finasteride, Vitamin D, B12, Iron, and Ketoconazole shampoo. Despite a hair transplant and improved blood levels, he continues to experience hair loss and suspects a possible misdiagnosis of Alopecia Areata Incognita.

community mbp alopecia areata or vitamin deficiency

in Chat 1 year ago

A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

community Pyrilutamide +Alfatradiol 0.1% , no Hairloss anymore

in Treatment 43 upvotes 1 year ago

OP experienced diffuse thinning for 11 years and used Minoxidil and Finasteride previously. They now use Pyrilutamide 0.5% and Alfatradiol 0.1%, resulting in significantly reduced hair loss.

community Purchasing and Shipping Alpecin DMG to the United States.

in Product 3 upvotes 6 months ago

A user is seeking help to purchase and ship Alpecin DMG to the United States due to issues with eBay sellers. They prefer Alpecin DMG over minoxidil because of concerns about minoxidil's effects on insulin production, as they have diabetes.

community Alfatradiol Experience (2 months)

in Treatment 12 upvotes 5 years ago

User experienced side effects from oral finasteride and tried topical Alfatradiol for hair loss. Alfatradiol provided maintenance without significant regrowth, and user suggests it as an alternative for those struggling with finasteride side effects.

community Evolution theory: AGA is your body trying to reduce the risk of prostate cancer by exposing your scalp to more UV

in Research/Science 4 months ago

Androgenic alopecia (AGA) might have evolved to reduce prostate cancer risk by increasing UV exposure to the scalp, but this theory is debated. Treatments like minoxidil and finasteride are used for AGA, though the exact causes and evolutionary reasons for hair loss are unclear.

community hello

145 upvotes 7 years ago

A 12-year-old diagnosed with alopecia shares their experience and current treatments, including Dermovate, an unnamed cream, and liquid iron. The community offers support and encouragement.

community Alfatradiol 1% study rebuttal.

in Research/Science 4 upvotes 2 years ago

Alfatradiol is often discussed at a 1% concentration, but studies typically use 0.025%. Some users report success using it as a topical treatment alongside other hair loss treatments like finasteride.

community Olumiant alternative for Alopecia Areata?

in Treatment 1 upvotes 3 years ago

A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

community Alfatradiol to combat hair loss

8 upvotes 12 years ago

Hair loss discussion includes treatments Minoxidil, Finasteride, and RU58841. Alfatradiol is suggested as another potential solution.

community High Dose 0.1% Alfatradiol + 1% Pyrilutamide stopped my Hairloss completely

in Treatment 33 upvotes 1 year ago

Using 0.1% Alfatradiol and 1% Pyrilutamide stopped hair loss, reducing shedding from over 150 hairs a day to less than 10, with no side effects. The user also uses Minoxidil and microneedling, applying the treatments twice daily.

community Using Fin and Alfatradiol in conjunction?

in Finasteride/Dutasteride 5 upvotes 4 years ago

User considers adding Alfatradiol to their topical finasteride treatment for hair loss. Others discuss Alfatradiol as a weak estrogen and 5α-reductase inhibitor used for pattern hair loss in men and women.

community Success: My Doc prescribed me 0.1% Alfatradiol

in Treatment 13 upvotes 1 year ago

A user shared their success in getting a prescription for 0.1% Alfatradiol, a topical treatment for hair loss similar to finasteride but with fewer side effects. They found a pharmacy to compound it and will update on the results.

community Alfatradiol is a topical 5AR inhibitor that this study shows is effective in stopping hair loss without sides. It can be bought OTC in Europe right now. Thoughts?

13 upvotes 9 years ago

Hair loss treatments, specifically the use of Alfatradiol as an over-the-counter topical 5AR inhibitor that has been shown to be effective in stopping hair loss without side effects. Other treatments discussed include Minoxidil, finasteride and RU58841.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 736 upvotes 3 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Alpha plus from Anagenica - 25%CB???

in Product 2 upvotes 2 years ago

A user ordered Alpha Plus from Anagenica, expecting it to contain specific percentages of Fin, Estradiol, Minoxidil, and CB0301. However, the received product's label showed different percentages, including a surprising 25% CB, leading the user to question its safety and accuracy.

community Alfatradiol anyone? Anyone added it to their regimen and found it helps?

in Treatment 4 upvotes 3 years ago

Alfatradiol helps reduce hair shedding and itching, and is effective for mild hair loss. Users combine it with treatments like fluridil, minoxidil, and sometimes consider finasteride.

community A Short Recap on PP405 and AAD 2026

in Update 2 weeks ago

PP405 is a promising experimental topical treatment for alopecia that reactivates dormant hair follicles by targeting cellular energy, with large-scale trials planned for 2026. While it shows potential, it cannot regenerate permanently destroyed follicles, making hair transplants the only guaranteed solution for advanced baldness currently.

community Why is no one talking about alfatradiol?

in Treatment 22 upvotes 1 year ago

Alfatradiol is discussed as a hair loss treatment with minimal side effects, but its effectiveness is debated, and it's not widely known or available outside Germany. Some users report side effects like gyno and ball ache, while others find it effective in stopping shedding and itching.

community Alfatradiol!!! Does anyone use this as part of their stack and can actually comment on its effectiveness?

in Treatment 2 upvotes 1 year ago

Alfatradiol is used by some for hair loss, often alongside treatments like finasteride, RU58841, and minoxidil, but its effectiveness is unclear. Some users report no significant improvement, while others note reduced sebum production but experience side effects like gallbladder pain.

community PP405 is NOT gray market jxl069

in Technology 26 upvotes 2 months ago

PP405 is a safer alternative to JXL069 for hair loss treatment because it penetrates the skin effectively and degrades in the blood, avoiding systemic toxicity. JXL069, when forced into the body, can cause dangerous side effects like lactic acidosis due to its inability to degrade safely.

community any news about DUPA (Diffuse unpatterned alopecia)?

in Research/Science 8 upvotes 3 years ago

The conversation discusses diffuse unpatterned alopecia (DUPA) and its possible causes, including sensitivity to DHT, not being androgenic alopecia, being diffuse alopecia areata, or hormonal issues. Treatments mentioned include topical melatonin, Clobetasol Propionate for alopecia areata, and the lack of results from using finasteride, dutasteride, and minoxidil.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 62 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.