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A 32-year-old male experienced erectile dysfunction and decreased libido after using oral dutasteride and minoxidil for hair loss. He is considering switching to topical alternatives like Xyon dutasteride or RU58841 to reduce side effects.

The conversation discusses using scalp antiandrogens like RU58841, pyrilutamide, or fluridil on the face to reduce sebum production, noting that clascoterone (winlevi) is an approved facial antiandrogen with underwhelming reviews.

Topical spironolactone is discussed for hair loss treatment, with mentions of DIY solutions and dermatologist compounding. Users inquire about regrowth and sourcing the treatment.

A user is seeking experiences with adenosine for hair loss, asking about its effectiveness, usage duration, and combination with treatments like minoxidil, finasteride, or RU58841. Another user mentions difficulty sourcing adenosine and comments on the mixed quality of research.

The potential effectiveness of homemade topical spironolactone in treating hair loss, with studies suggesting it is more effective than finasteride and even minoxidil when used as monotherapy. The conversation also mentions that other anti-androgens are being developed which may soon hit the market.

Tretinoin can make minoxidil more effective for hair loss treatment, but some users did not see improved hair density with this combination and had better results with dutasteride.

The conversation discusses using finasteride, dutasteride, RU58841, and testosterone to combat hair loss and block DHT, with some users expressing concerns about side effects and vegan options for medication. The discussion also touches on personal experiences with hormone treatments and the desire to maintain a youthful appearance.

Taking creatine does not affect the effectiveness of finasteride for hair loss. Users generally agree that creatine is safe to use alongside finasteride and minoxidil.

A 26-year-old is experiencing worsening hair thinning despite using dutasteride 0.5 mg and oral minoxidil 5 mg, alongside ketoconazole for seborrheic dermatitis. Users suggest patience, as results may take 12–18 months, and consider increasing the dutasteride dosage or consulting a dermatologist.

A user has been using finasteride and minoxidil for hair loss without success and is considering switching to dutasteride. They are concerned about low DHT levels and are seeking advice on how to implement dutasteride effectively.

Oral dutasteride and topical Minoxidil are used to treat hair loss, with the goal of suppressing DHT and improving hair density. The effectiveness depends on genetics and the duration of baldness, and lifelong treatment may be necessary to maintain results.

Combining pyrilutamide and alfatradiol might be as effective as finasteride for hair maintenance. The user plans to try this combination alongside minoxidil and keto shampoo, hoping for improved hair thickness.

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

A user questions if a topical compound with finasteride, dutasteride, minoxidil, retinoic acid, caffeine, and triamcinolone is excessive for hair loss treatment. Another user shares their experience using topical finasteride without issues and notes that alternating finasteride and dutasteride is common.

A user reported worsening hair shedding and thinning after 6 months of daily dutasteride, despite also using minoxidil, bicalutamide, and recently adding RU58841. They are considering stopping dutasteride due to lack of improvement.

A user shared a 1-year update showing hair regrowth from taking 1mg Dutasteride and 2.5-5mg oral Minoxidil daily for Diffuse Unpatterned Alopecia. Some comments praised the results, while others criticized the user's behavior and questioned potential side effects.

Higher doses of dutasteride for hair loss are debated, with some users suggesting they are unnecessary and potentially unsafe. The original poster uses a combination of dutasteride, minoxidil, and RU58841 for hair regrowth, despite concerns about high dosages.

The user has been using 0.5 mg dutasteride daily for 8 months and 5 mg oral minoxidil for 14 months to address hair thinning. Despite some users seeing no change or improvement, the user feels their hairline density has decreased and corners have worsened.

Switching to dutasteride as a hair loss prevention treatment, along with minoxidil, dermarolling and nizoral shampoo, and the potential benefits and side effects of using finasteride and/or dutasteride in combination with topical anti-androgens like RU58841.

Late 20s woman struggles with worsening hair loss and tried various treatments without success. Now trying spironolactone and ketokonazole shampoo, hoping for improvement.

The user is asking if using a 10% fluridil formulation would be effective for blocking scalp androgens in addition to their current treatment of oral dutasteride.

Switching from daily 0.5mg dutasteride to three times a week may reduce side effects without worsening hair loss. Bloodwork showed no abnormalities, supporting the change.

The user is experiencing rapid hair loss despite using dutasteride, minoxidil foam, and ketoconazole shampoo, and is concerned about waiting longer to see results. A suggestion was made to consult a dermatologist for a tricoscopy and consider higher doses of dutasteride, while also checking for nutritional deficiencies and thyroid issues.

Hair loss discussion includes treatments Minoxidil, Finasteride, and RU58841. Alfatradiol is suggested as another potential solution.

The conversation discusses the approval of Kintor Pharmaceutical's AR-PROTAC (GT20029) for clinical trials in China for acne and androgenic alopecia. One user expresses optimism about new treatments being developed and seeks clarification on how the new drug works, specifically if it temporarily degrades the AR protein to reduce DHT sensitivity in hair follicles.

A 35-year-old shared their 1-year hair loss treatment progress using 0.5mg Dutasteride, 5mg oral Minoxidil, topical Minoxidil, and Ducray Anaphase+ shampoo daily, noting significant changes after 4 months despite some shedding. They reported minor side effects and followed their dermatologist's advice for the treatment plan.

A user noticed increased hair loss and was prescribed Betamethasone dipropionate 0.05% lotion by a dermatologist. Another user suggested changing doctors and asking for finasteride instead.

Using both finasteride and dutasteride for hair loss is debated, with some seeing it as beneficial during transition, while others find it redundant and risky. Oral minoxidil raises concerns about blood pressure, with a preference for topical use and microneedling for better results.

Hair loss discussion includes topical spironolactone treatment, used 1-2 times daily for 2 weeks with no changes yet. Minoxidil and Propecia caused nasty side effects for the user.

A 29-year-old woman with genetic hair loss started using 0.5 dutasteride a week ago and has noticed increased shedding, no sexual side effects, and less oily skin. She plans to provide updates and is not concerned about potential birth defects as she doesn't plan to have more children.