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      community Androgen degraders for hair loss

      in Research/Science  60 upvotes 1 year ago
      The conversation discusses androgen receptor degraders for hair loss, highlighting their potential advantages over traditional AR blockers like RU58841 and pyrilutamide. Concerns about the safety and cost of these treatments are also mentioned.

      community Why was fluridil abandoned and never made past phase 2?

      in Chat  4 upvotes 4 years ago
      Fluridil was abandoned due to its weak effectiveness and low binding affinity to the androgen receptor, making it less competitive against DHT and testosterone. Users discuss its limited results compared to other treatments like pyrilutamide and RU58841.

      community PP405 Hair Loss Drug: Phase 1 Human Results & Biopsy Insights

      in Research/Science  213 upvotes 1 year ago
      PP405 is a potential hair loss treatment undergoing trials, with discussions on its effectiveness and comparison to existing treatments like finasteride and minoxidil. There is skepticism about its status as a cure, with hopes for future advancements in genetic treatments like CRISPR.

      community Dutasteride shedding starts at month 4?

      in Treatments  66 upvotes 9 months ago
      Dutasteride can cause hair shedding, which may start around the fourth month of treatment. The user is concerned about whether this shedding is due to the medication or the progression of hair loss.

      community So is this the actual trial results for pp405?????

      in Research/Science  93 upvotes 2 weeks ago
      PP405 shows promising results for hair growth, potentially outperforming finasteride without side effects like erectile dysfunction. Users discuss using treatments like minoxidil, pyrilutamide, nizoral, and alfatradiol while waiting for PP405's availability.

      community 4 months .5 Dut and 3 months 2.5 Minox update

      in Progress Pictures  24 upvotes 7 months ago
      The user reports positive results from using 0.5 mg dutasteride daily for four months and 2.5 mg oral minoxidil for three months, with no side effects. They switched from topical minoxidil to this oral combination.

      community RU58841 alone vs. with Fin / Dut

      in Finasteride/Dutasteride  11 upvotes 2 years ago
      RU58841 combined with finasteride or dutasteride is more effective than RU58841 alone for hair loss. Users suggest combining these with minoxidil and microneedling for better results.

      community Finally got hold of 0.1% latanoprost

      in Treatment  6 upvotes 3 weeks ago
      The conversation is about a user obtaining a compounded treatment for hair loss, including 0.1% latanoprost, 0.2% melatonin, and 1% cetirizine. The user also uses 2.5 mg dutasteride, 5 mg minoxidil, and RU58841 daily, and is at Norwood 2.

      community Lowest Effective RU58841 Dose?

      in Treatment  4 upvotes 1 year ago
      RU58841 is discussed as a hair loss treatment, with users considering lower doses like 2.5% to reduce costs. Some users suggest that if already blocking DHT, lower doses might still be effective unless there's high sensitivity to DHT.

      community About GT20029's Efficacy and Strength

      in Chat  7 upvotes 3 years ago
      The conversation is about the effectiveness and production of GT20029, a drug being developed as a topical androgen receptor degrader for hair loss, and whether it can fully degrade androgen receptors or only partially. It also discusses the drug's potential unique working mechanism and synthesis by a company called Anagen.

      community Hair loss treatments rated (by gpt-4)

      in Research/Science  252 upvotes 3 years ago
      Rating treatments for hair loss, with the help of GPT-4, according to efficacy, evidence and tolerability; a combination of chemicals from research papers, custom compounds, and some suggestions from other users were included.

      community 4 years of dutasteride monotherapy

      in Progress Pictures  191 upvotes 2 years ago
      The conclusion of the conversation is that the user experienced noticeable regrowth of hair after using dutasteride as a single treatment for about 1.5 years. No before photos were available.

      community Finasteride vs RU58841 vs Dutasteride for MPB, Diffuse Thinning, or Retrograde Alopecia

      in Minoxidil  6 upvotes 1 year ago
      The user is seeking advice on the best treatment for male pattern baldness, diffuse thinning, and retrograde alopecia, comparing the effectiveness of finasteride, RU58841, and dutasteride, and considering whether to add minoxidil or switch to dutasteride or combine treatments. They are currently on finasteride and are contemplating if adding RU58841 or switching to dutasteride is better, and also asking about the comparison between pyrilutamide and RU58841.

      community Lyphar Biotech. China source for RU58841

      in Research/Science  1 upvotes 1 month ago
      The conversation discusses the safety and trustworthiness of ordering RU58841 from Lyphar Biotech in China, with a focus on pricing and reliability. The user is seeking advice on whether to proceed with the purchase or consider alternative sources.

      community Making RU58841 but actually good

      in Chat  3 upvotes 1 year ago
      The conversation discusses creating a foam version of RU58841 for easier application on thick hair, comparing it to minoxidil foam. The user currently uses dutasteride, minoxidil, and needling for hair loss treatment.

      community What is fluridil binding affinity?

      in Treatment  4 upvotes 4 years ago
      Fluridil is hard to obtain and only available in Slovakia and Czechia, with no systemic side effects but possibly limited effectiveness compared to finasteride. The original poster is using finasteride and minoxidil without success and is considering trying fluridil despite its cost.

      community 1 year 5-ar. Blood test results

      in Finasteride/Dutasteride  3 upvotes 8 months ago
      The user experienced sexual side effects after starting finasteride and later switched to dutasteride, noticing hormonal changes. They are considering using P5P and possibly aromatase inhibitors to manage high prolactin and estradiol levels.