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      Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

      community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

      in Research  413 upvotes 1 year ago
      Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

      community Oral minox + dut

      in Research/Science  8 upvotes 5 years ago
      The conversation discusses hair loss treatments using oral minoxidil, oral dutasteride, and mesotherapy dutasteride, showing impressive 6-month results. The user wishes these treatments were available in the U.S.

      community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

      in Research/Science  93 upvotes 4 years ago
      The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

      community Oral minoxidil kullanan var mi?

      in General  122 upvotes 7 months ago
      The conversation is about finding a reliable source for oral minoxidil in Turkey, preferably in original packaging, and concerns about the safety and effectiveness of local products. The user is seeking recommendations for trustworthy suppliers and is wary of counterfeit products and scams.

      community Breezula CB-03-01

      in Treatment  11 upvotes 6 years ago
      The conversation is about a potential new hair loss treatment called Breezula CB-03-01. Users are discussing updates on its development and sharing personal experiences with making or using it.

      community Anyone used CB-03-01 (clascoterone), is it worth it, too risky??

      in Research/Science  2 upvotes 2 years ago
      The user experienced side effects from low-dose topical finasteride and is considering using clascoterone (CB-03-01) despite concerns about its risks and cost. They seek advice on its effectiveness and potential side effects compared to other treatments like alfatradiol and fluridil.

      community is there any news about pp405 please

      in Update  11 upvotes 1 year ago
      There is no new information on pp405, with data collection expected to finish by the end of 2025. Users are discussing the timeline for data analysis and completion of Pelage Pharmaceuticals' phase 2 study.

      community Hair loss as a hijabi in the middle east

      in Female  40 upvotes 4 years ago
      A woman experiencing hair loss, exacerbated by wearing a hijab, is seeking advice for her upcoming wedding. She has tried various treatments, including minoxidil, finasteride, and stem cell therapy, and is considering using hair fibers and extensions to cover her scalp.

      community Bicalutamide effect on androgens?

      in Treatment  4 upvotes 5 years ago
      Bicalutamide blocks androgen receptors, preventing testosterone and DHT from binding, which can help with hair loss but may cause feminization. It is not recommended for those who do not want feminization effects.

      community PP405 is out for sale on everychem.

      in Product  98 upvotes 10 months ago
      PP405 is suspected to be a scam, with users doubting its legitimacy and effectiveness. Many recommend using proven treatments like finasteride and minoxidil.

      community Can't afford 2.5mg dutasteride, any alternative?

      in Finasteride/Dutasteride 1 year ago
      The user is struggling with hair loss despite using topical minoxidil, finasteride, and oral dutasteride, and is seeking affordable alternatives to 2.5mg dutasteride. Suggestions include checking for scalp inflammation, considering oral minoxidil, using rosemary oil, and possibly trying saw palmetto, though results may vary.

      community We need to talk about DHT itch

      in Treatment 3 years ago
      DHT Itch and its link to balding, with various treatments such as finasteride being discussed. Members shared their experiences of scalp itch before and after taking 5AR inhibitors, and potential underlying causes such as seborrheic dermatitis were discussed.

      community treatment of Bicalutamide low dose weekly?

      in Treatment  5 upvotes 4 years ago
      The conversation is about using bicalutamide, taken less frequently than daily, for hair loss treatment. The user is considering 50mg every 3 days or once a week and is asking for others' experiences.

      community Anyone know cheapest/best way to source RU58841 for Aussies?

      in Product  2 upvotes 3 months ago
      The conversation is about sourcing RU58841 for hair loss treatment in Australia and discusses the lack of effective alternatives. Alternatives mentioned include Kx826, fluridil, cb, alfatradiol, and topical spiro, but they are considered weak compared to RU58841.

      community 1 year 5-ar. Blood test results

      in Finasteride/Dutasteride  3 upvotes 11 months ago
      The user experienced sexual side effects after starting finasteride and later switched to dutasteride, noticing hormonal changes. They are considering using P5P and possibly aromatase inhibitors to manage high prolactin and estradiol levels.

      community Does anyone use Fluridil as their anti-androgen of choice?

      in Chat  5 upvotes 2 years ago
      Fluridil, a non-steroidal anti-androgen approved for alopecia in parts of Europe, is noted for its low side effects but is not commonly discussed. The user is inquiring if anyone prefers it over other anti-androgens like Spiro or RU58841.

      community Bile Acid-Mediated DHT Dysregulation Hypothesis

      in Research/Science  13 upvotes 1 year ago
      Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

      community Why was fluridil abandoned and never made past phase 2?

      in Chat  4 upvotes 4 years ago
      Fluridil was abandoned due to its weak effectiveness and low binding affinity to the androgen receptor, making it less competitive against DHT and testosterone. Users discuss its limited results compared to other treatments like pyrilutamide and RU58841.

      community Pyrilutamide 0.5 or 0.025% topical fin for maintaining?

      in Basic Questions  91 upvotes 1 month ago
      The user is considering switching from pyrilutamide to 0.025% topical finasteride due to concerns about effectiveness and past side effects from a scalp elixir. They aim to maintain hair until new treatments like breezula or GT00029 become available.

      community hight pre-finasteride estrogen levels

      in Finasteride/Dutasteride  1 upvotes 2 years ago
      A user with high pre-finasteride estrogen levels is asking if they need to normalize their hormone levels before starting finasteride and whether they should postpone dermarolling until they begin finasteride. The user is 21.5 years old.
      Eliminate/Confirm AGA based on blood report

      community Eliminate/Confirm AGA based on blood report

      in General  126 upvotes 1 year ago
      A 19-year-old male with no family history of androgenetic alopecia (AGA) is experiencing hair loss and considering using a topical minoxidil and finasteride mixture. Despite low vitamin D levels and normal DHT serum levels, he seeks confirmation of AGA before starting treatment.

      community Why doesn't phase 3 of PP405 start straight away?

      in Chat  14 upvotes 6 months ago
      Pelage is delaying the start of phase 3 trials for PP405 to 2026 due to necessary regulatory processes, despite having $120 million in funding. Users discuss the potential of PP405 for hair regrowth, with some expressing skepticism and others hopeful for new treatments like Breezula.

      community Hair transplant AI simulations research

      in Transplants  6 upvotes 3 years ago
      A user developed AI software to simulate hair transplants on photos, helping people visualize potential results. The tool offers photo-realistic renderings but advises caution regarding exact outcomes due to various factors.

      community Can’t take fin - options/alts?

      in Finasteride/Dutasteride  6 upvotes 4 years ago
      User seeks non-finasteride hair loss treatments, suggests Eucapil, minoxidil, microneedling, keto shampoo, oral castor oil, and alfatradiol. Reply recommends vitamin D, zinc, pumpkin seed oil, saw palmetto, and high black tea intake, but emphasizes minoxidil and microneedling as most effective.

      community Autologus Exosomes, anyone tried it ?

      in Technology  2 upvotes 10 months ago
      Autologous exosome treatment for hair loss is being discussed as an emerging option. Minoxidil, finasteride, and RU58841 are also mentioned as treatments.