community Trial for TDM-105795 update from research office
The trial for TDM-105795 has been completed, and it was in phase 2A. The discussion seeks input on the next phases, 2B or 3, based on safety and efficacy.
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community Hairline still receding during finasteride
The user has been using Finasteride for over four months to treat androgenetic alopecia but continues to experience hair loss and thinning. They recently started using Minoxidil and are considering switching to Dutasteride due to concerns about Finasteride's effectiveness.
community 16 advice on routine I’m beginning
The user is experiencing hair thinning and bald spots, using Nizoral, rosemary oil, fluocinolone, and receiving PRP treatments. They are considering oral minoxidil and finasteride but are hesitant due to age and financial constraints.
community Can liver problems be associated with response to the oral minoxidil?
Liver problems may reduce the effectiveness of oral minoxidil due to impaired SULT1A1 enzyme activity, which is crucial for converting minoxidil to its active form. This reduction in enzyme function can significantly decrease the drug's effectiveness in promoting hair growth.
community Rare Non responder to Finasteride, Dutasteride, and oral minoxidil
A user did not respond to finasteride, dutasteride, and oral minoxidil for hair loss after four years of treatment and is considering scalp micropigmentation (SMP). Other users suggest the hair loss pattern may indicate alopecia areata and recommend seeing a dermatologist.
community I can't take care of myself because of hair loss.
The conversation is about a user feeling hopeless due to hair loss despite using finasteride, dutasteride, and OM for over a year. Responses suggest therapy, self-improvement, and changing perspectives on appearance.
community Hair loss whodunit: help me find the culprit!
The user is experiencing hairline thinning despite using finasteride, minoxidil (solution and foam), dermastamping, and tretinoin. They suspect minoxidil or tretinoin might be causing the issue but are unsure.
community 19M Experiencing Headaches and Brain Fog on 1.25mg Finasteride Week 2
The user is experiencing headaches and dizziness two weeks after starting finasteride at 1.25mg, concerned about potential brain fog affecting math studies. They mention hearing that headaches can be normal after starting finasteride.
community EU Shouldn't Ban Fin & Dut: PFS is NOT REAL.
Finasteride and Dutasteride do not cause depression or "Post Finasteride Syndrome," with concerns often linked to the nocebo effect and preexisting mental health issues. The EU is unlikely to ban these drugs, but access may become more restricted due to ongoing debates.
community Diagnosed with female pattern hair loss as a male with recent aggressive loss. Preemptively mourning the only part of myself I’ve ever come close to loving. Lost all motivation to do anything with my life.
The conclusion of the conversation is that the user should consider using treatments such as finasteride, minoxidil, and RU58841 to potentially reverse their hair loss. Other suggestions include using hair loss concealers and maintaining a healthy diet.
community Burning sensation and acne along temples accompanied by aggressive recession. On 0.5mg dut, 1.25mg fin EOD, and oral min 5mg daily.
The user experienced temple recession, shedding, and acne while on 0.5mg dutasteride, 1.25mg finasteride every other day, and 5mg oral minoxidil daily. They are considering switching treatments due to worsening symptoms and are contemplating using a topical anti-androgen like RU58841.
community Breezula hasn't even begun phase 3 trials yet. F*cking hell.
The conversation is about the delay in Breezula's phase 3 trials and skepticism regarding its effectiveness compared to other treatments like RU58841 and Pyrilutamide. Some users prefer safety over effectiveness, while others express frustration with the slow progress and doubt Breezula will be a significant treatment for hair loss.
community Anybody else have family in denial over your hair loss?
A 20-year-old discusses family denial about his hair loss, diagnosed with seborrheic dermatitis, folliculitis, and male pattern baldness. He is prescribed Dutasteride and oral Minoxidil for treatment.
community 22M Dut+min+microneedling. Diffuse AGA.
A 22-year-old male uses dutasteride, a serum with 10% minoxidil and 0.5% finasteride, and microneedling for diffuse androgenetic alopecia. Progress pictures show changes from July 2025 to February 2026.
community HMI 115 Phase 1 update: Changes to clinicaltrials.gov page
A Phase 1 update for the HMI 115 clinical trial, which involves 16 participants and is expected to end in July 2023; as well as changes to the recruitment process, including treatment protocols with Minoxidil, Finasteride, and RU58841.
community Need help recovering from saw palmetto!
The user experienced a significant drop in libido and energy after taking saw palmetto, which they believe caused these changes. They are seeking advice and reassurance, with some users suggesting that the effects may not be permanent and could improve over time with a healthy lifestyle.
community M29 Struggling with motivation on Fin/Min - is it all in my head?
A 29-year-old is struggling with motivation while using finasteride and minoxidil for hair loss, experiencing side effects like low libido. They have seen some hair growth but are unsure whether to continue treatment or shave their head again.
community Is anyone using alfatradiol as part of their stack?
The conversation is about using alfatradiol as a hair loss treatment. The user is considering adding it to their regimen because it is safe, mild, and easily available in Europe.
community I wrote a poem about pp405 (potential treatment)
A poem humorously suggests hope for a new hair loss treatment, PP405, while users debate the effectiveness and side effects of current treatments like Finasteride. Concerns are raised about Finasteride's side effects, especially for young users, and skepticism about new treatments is expressed.
community Anyone else only begin to experience diffuse thinning AFTER starting treatment?
Many users experienced increased diffuse thinning after starting finasteride, with some switching to dutasteride or adding minoxidil in hopes of improvement. Thyroid issues and low ferritin levels were also discussed as potential factors affecting hair loss.
community Progress finasteride and minoxidil + problem
The user is experiencing hair improvement in the central and back areas after using finasteride, minoxidil, and a galenic lotion, but the temple area is worsening. They suspect the lotion might be causing the issue and are considering stopping its use.
community Why does finasteride stop working?
Finasteride may seem less effective over time due to increased DHT sensitivity or aging, but it still suppresses DHT. Switching to dutasteride offers stronger DHT suppression but may increase estrogen levels.
community Question about medications ...
Hair loss treatments like spironolactone often require lifelong use to maintain results. Stopping the medication can lead to increased testosterone levels and potential hair loss.
community I remember where i was when the Dht first attacked.
Hair loss due to DHT is causing distress, with Minoxidil, finasteride, and RU58841 being potential treatments. The conversation includes humor and frustration about the topic.
community Clooney - time to switch to dut for temples?
The conversation humorously discusses George Clooney's hair and aging, suggesting he switch to dutasteride for his temples. It also mentions minoxidil and finasteride, debating the effects of hair dye and styling on his appearance.
community Facial hair loss
User noticed beard and sideburn hair loss, and thinning eyebrows, diagnosed with alopecia barbae and male pattern baldness, and prescribed Desonide cream. User seeks feedback on Desonide cream.
community After quitting min and fin I asked AI on how fix the mess I am in and it says:
Prolonged use of topical minoxidil and finasteride can lead to neuroendocrine and autonomic dysfunction, causing severe sensitivity and side effects. Recovery involves avoiding these treatments, supporting neurosteroid recovery, calming the sympathetic system, and rebuilding scalp health naturally.
community 21M on Finasteride & Topical Minoxidil: Is My Frontal Thinning AGA or TE?
A 21-year-old is experiencing hair thinning and is using oral finasteride and topical minoxidil, considering adding oral minoxidil. They are unsure if the condition is androgenetic alopecia (AGA) or telogen effluvium (TE) and are advised to continue treatments and get a blood test.
community 13mos progress. Everything is fairly recovered but crown struggling for months now. Advice?
The user has mostly recovered hair density using finasteride, alternating oral and topical minoxidil, and occasional dermarolling, but the crown area is still struggling. Advice includes continuing treatment for up to 24 months and possibly consulting a doctor if issues persist.
community Updated hairloss treatments for Androgenetic Alopecia
The conversation discusses treatments for Androgenetic Alopecia, including Minoxidil, finasteride, RU58841, and topical caffeine. It emphasizes that there are multiple treatment options available in 2025.