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      community Hair loss over a year following depression and taking antidepressants

      in Side effects?  200 upvotes 5 months ago
      A 33-year-old experienced significant hair loss after a depressive episode and taking paroxetine, possibly due to telogen effluvium or androgenic alopecia. Suggestions included reducing alcohol, considering finasteride and minoxidil, and consulting a doctor about antidepressant side effects.

      community 6 months on dutast and minoxodil, hair growing like weeds now!

      in Progress Pictures  618 upvotes 11 months ago
      A woman experienced significant hair regrowth after six months of using dutasteride and minoxidil, despite initial hair loss due to androgenetic alopecia. She reported minimal side effects and highlighted the effectiveness of these treatments for women, despite doctors' hesitancy to prescribe them.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Why is there so many people claiming Dutasteride destroyed their hair?

      in Chat  25 upvotes 2 years ago
      Some people claim Dutasteride worsened their hair loss, causing concern among users. Reasons suggested include initial shedding phases, incorrect attribution to Dutasteride when other factors are involved, genetic variations affecting drug response, and the possibility of non-authentic medication.

      community Post Finasteride Syndrome, A dangerous lie.

      in Chat  142 upvotes 2 years ago
      A user initially had side effects from finasteride, attributed them to anxiety and the nocebo effect, and after resuming the drug, experienced positive effects and now warns against misinformation about Post Finasteride Syndrome.

      community Saying creatine causes loss on fin/dut makes no sense and this is why

      in Finasteride/Dutasteride  42 upvotes 2 years ago
      The conversation discusses whether creatine causes hair loss for those using finasteride or dutasteride, with some suggesting creatine might increase DHT or upregulate androgen receptors, potentially leading to hair loss. Others argue the evidence is not conclusive, citing limited studies and personal anecdotes, with some avoiding creatine as a precaution.

      community KX-826 Phase 3 Failed. Sorry guys...

      in Research/Science  48 upvotes 2 years ago
      The conversation discusses the failure of Phase 3 trials for the hair loss treatment KX-826, with no significant difference found between the drug and placebo. Some users express disappointment and skepticism, while others discuss alternative treatments like Minoxidil, finasteride, and RU58841.

      community M23 , on finaestride and minoxidil for 4.8 months

      in Progress Pictures 3 years ago
      . This conversation is about a user's progress while using minoxidil and finasteride to treat hair loss, with emphasis on taking oral finasteride at night before bed for optimal results. They also discuss the brand of medication being used (Morr F 5%) and the importance of taking a generic version of the same drug.

      community Kintor’s GT20029 Phase 1 success

      in Update  74 upvotes 3 years ago
      Kintor's GT20029, a treatment for hair loss, has completed Phase 1 successfully, showing promise as an androgen receptor degrader that could potentially regrow hair. It is considered more effective than Pyrilutamide, with infrequent dosing and minimal systemic absorption.

      community 1 month Pyrilutamide. A non responders story to everything.

      in Research/Science  218 upvotes 3 years ago
      My hairline, I am only 23. This conversation is about a user's experience with treatments for androgenic alopecia, including finasteride, dutasteride, RU, minoxidil, progesterone, melatonin, LLLT, oral minoxidil, and Pyrilutamide. They have tried many treatments over the course of two years without seeing much success, and they are considering getting a hair system as a last resort.

      community Does melatonin dissolve in isopropyl alcohol

      in Technology  7 upvotes 3 years ago
      The conversation discusses making a topical melatonin solution for hair loss treatment, questioning if isopropyl alcohol can dissolve melatonin. Melatonin is soluble in lipids and alcohol, but it's unstable and should be mixed fresh regularly; it may help hair growth by affecting certain cellular signaling pathways and has anti-androgenic effects.

      community Losing hair for 3 years (24 yrs old)

      in Chat  26 upvotes 5 years ago
      User losing hair for 3 years tried shampoos, minoxidil, derma rolling, finasteride, and Adegen's 15% minoxidil protocol without success. Another user suggests lowering finasteride dosage and trying topical non-steroidal anti-androgens like Fluridil, RU58841, and Breezula.

      community Injecting stomach fat into the scalp could cure baldness in just six months

      in Update  114 upvotes 7 years ago
      A potential treatment for hair loss that involves injecting fat into the scalp; the role of testosterone and estrogen in thinning fat tissue under the skin; research on using lard to treat androgenic alopecia, as well as PRP + ACELL/amniotic stem cell treatments; and ongoing clinical trials by doctors involved in the study.

      community When is the cure gonna drop , how much more time

      in Research/Science  112 upvotes 3 months ago
      There is no imminent cure for hair loss, but treatments like Minoxidil, Finasteride, and new drugs such as KX-826, GT-20029, and PP405 are being explored. Current solutions focus on slowing hair loss and stimulating growth, with hopes for better options in the future.

      community I wish pp405 work and i have full head of hair in 2028-2030

      in Chat  106 upvotes 7 months ago
      People are hopeful about future hair loss treatments like PP405, GT20029, and VDPHL01, while some are currently using finasteride and minoxidil. There is skepticism about the effectiveness of new treatments, and some advise against hair transplants until more promising drugs are available.

      community Let's talk about natural options and last resorts.

      in Chat  7 upvotes 2 years ago
      The user discusses their long struggle with hair loss, considering various treatments like hair transplants, hair systems, and natural methods such as micro-needling, vitamin supplements, and a healthy lifestyle. They express concerns about side effects from drugs like finasteride and ultimately lean towards using a hair system for better appearance and confidence.

      community I’m Feeling so discouraged and depressed - No one wants to prescribe finasteride to me.

      in Finasteride/Dutasteride  68 upvotes 2 years ago
      A user in France is frustrated because three dermatologists refused to prescribe finasteride for their hair loss, suggesting it's not androgenetic alopecia (AGA) and offering expensive vitamin treatments instead. Other users suggest buying hair loss treatments like minoxidil and finasteride from various online pharmacies and considering a gender-affirming care physician for more understanding treatment options.

      community Anyone else growing tired of the finasteride wars?

      in Finasteride/Dutasteride  169 upvotes 2 years ago
      The conversation is about differing experiences with finasteride for hair loss, with some users reporting side effects and others not, and the debate over the drug's safety and effectiveness. Specific treatments mentioned include finasteride, dutasteride, and topical finasteride.

      community If you’re on the fence about Finasteride, don’t wait!

      in Finasteride/Dutasteride  78 upvotes 3 years ago
      Finasteride, a medication for hair loss that has both positive and negative effects. Users discussed their own personal experiences with the drug as well as potential side-effects of taking it, such as erectile dysfunction or gynecomastia. Suggestions were also made about starting at a lower dosage to minimize these risks.

      community Dutasteride questions

      in Finasteride/Dutasteride  4 upvotes 5 years ago
      Switching to dutasteride as a hair loss prevention treatment, along with minoxidil, dermarolling and nizoral shampoo, and the potential benefits and side effects of using finasteride and/or dutasteride in combination with topical anti-androgens like RU58841.

      community Starting Propecia with pre-existing erecticle dysfunction

      in Finasteride  5 upvotes 9 years ago
      A 19-year-old with diffuse hair thinning and erectile dysfunction is considering starting Propecia (finasteride) while already using a minoxidil solution with anti-androgens. Concerns are raised about the psychological nature of erectile dysfunction and the potential systemic effects of anti-androgens, with suggestions to address porn addiction and consult a doctor about hormone therapy.

      community Summary of Procapil video by Haircafe

      in Minoxidil  2 upvotes 11 months ago
      Procapil is marketed as a natural hair loss treatment but lacks strong evidence and is industry-biased. Minoxidil and Finasteride are the only FDA-approved treatments for androgenetic alopecia.

      community The 'DHT itch' is real - notes from a casual bodybuilder

      in Chat  115 upvotes 1 year ago
      The "DHT itch" is real and likely due to inflammation at the hair follicle, exacerbated by increased testosterone or androgens. Treatments mentioned include dutasteride, minoxidil, finasteride, and various topical solutions.