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GlossaryAnionic Surfactants

carry a negative charge to effectively remove dirt and oils

Anionic surfactants, also known as anionic detergents, are a type of surface-active agent that carry a negative charge on their hydrophilic (water-attracting) end. This negative charge helps them effectively remove dirt and oils by breaking up and suspending these substances in water, making them common ingredients in shampoos, soaps, and other cleaning products.

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community AH-001 another topical AR degrader beside GT20029, completed Phase I

in Research/Science 9 upvotes 6 months ago

AH-001 is a new topical treatment designed to degrade androgen receptors, targeting the root cause of androgenetic alopecia without the side effects of oral treatments like finasteride. It has shown a strong safety profile and good local tolerability in early trials.

community Topical Finasteride with rogain foam as solvent

in Finasteride/Dutasteride 1 upvotes 4 years ago

The conversation discusses using Rogain foam as a solvent for topical finasteride due to an allergy to propylene glycol. The foam's ingredients, including alcohol SD 40B, are considered suitable for dissolving finasteride for easier application without skin irritation.

community Will a salicylic acid shampoo help remove flakes caused from propylene glycol?

in Treatment 2 upvotes 10 months ago

A user is experiencing scalp flaking from a finasteride/minoxidil topical solution and considers using salicylic acid shampoo to remove propylene glycol residue. Another user suggests trying a leave-in conditioner to address dryness and flaking.

community shampoo with piroctone olamine in US?

in Product 1 upvotes 4 months ago

The conversation is about finding a reasonably priced shampoo with piroctone olamine in the US. The user is cautious about trying new or smaller brands.

community Sodium Laureth Sulfate (SLS) in shampoos

4 upvotes 10 years ago

Sodium Laureth Sulfate (SLS) in shampoos and its potential impact on thinning hair. The user follows a regimen of shampoo, keto shampoo, and conditioner, seeking suggestions for better products.

community Topical Finasteride -- Without Propylene Glycol (PG)

in Finasteride/Dutasteride 2 upvotes 5 years ago

The user seeks alternatives to Propylene Glycol (PG) for delivering topical finasteride due to scalp irritation. They consider using Propanediol 1,3 and ask for other suggestions.

community Alpha plus from Anagenica - 25%CB???

in Product 2 upvotes 2 years ago

A user ordered Alpha Plus from Anagenica, expecting it to contain specific percentages of Fin, Estradiol, Minoxidil, and CB0301. However, the received product's label showed different percentages, including a surprising 25% CB, leading the user to question its safety and accuracy.

community possible treatment of AGA and change in sebaceous gland condition and oil production using sulfur soap

in Research/Science 4 upvotes 7 months ago

Sulfur soap may help with hair thickening and reducing scalp inflammation, but it can cause dryness. Nizoral, containing ketoconazole, is noted for its potential to reduce seborrheic dermatitis but may also cause scalp dryness and hair loss.

community Hydrophobic Finasteride. Why don’t we have it?

in Chat 7 upvotes 1 year ago

The conversation discusses the potential benefits of creating a hydrophobic version of finasteride to reduce systemic side effects while maintaining scalp health. It compares this idea to fluridil, which is designed to be hydrophobic and has less systemic absorption.

community Do silicone based shampoos/conditioners affect the absorption of topicald?

in Product 4 upvotes 2 years ago

Silicone-based shampoos and conditioners may leave a layer on the scalp that could affect the absorption of topical hair loss treatments like Fluridil. The user is considering switching to silicone products to manage frizzy hair but is concerned about this potential issue.

community Trichosol, polyethylene glycol, and DMSO

in Minoxidil 3 upvotes 2 years ago

The user experiences irritation from alcohols in minoxidil and is considering alternatives like trichosol mixed with polyethylene glycol or DMSO. They seek advice on the best nonirritating option.

community Best way to limit scalp irritation with topical fin?

in Finasteride/Dutasteride 1 upvotes 1 year ago

The user is experiencing scalp irritation from a compounded treatment of finasteride, minoxidil, and tretinoin. They are considering switching to a non-alcohol, propylene glycol-free formula with a lower tretinoin percentage to reduce irritation.

community Solvent for topical fin with low absorption

in Product 2 upvotes 1 year ago

The conversation is about using distilled water as a solvent for topical finasteride to reduce systemic absorption. The user is considering avoiding ethanol and propylene glycol to achieve this.

community Does anyone know the chemical formula for pelage pp405?

in Research/Science 14 upvotes 1 year ago

The conversation discusses the lack of public information on the chemical structure of PP405, a hair loss treatment, and the challenges of synthesizing it without a patent. It also explores a patent related to hydrogen-based topical formulations for reducing oxidative stress and inflammation.

community dandruff or skin dryness when using topical finasteride with propylene glycol

in Scalp Massage 4 upvotes 4 years ago

The conversation discusses using topical finasteride with propylene glycol, which causes scalp dryness or dandruff. The user also uses Nizoral, Nioxin, and DHT oil, and considers using a scalp conditioner to alleviate dryness.

community Piroctone olamine effective and better than ketoconazole?

in Product 2 upvotes 1 year ago

Piroctone olamine may be more effective and gentler than ketoconazole for dandruff and itchiness. Users report better results with piroctone olamine, but it is less available in the US.

community anti-androgens help with chronic seborric dermatitis ?! and hence diffuse thinning

in Finasteride/Dutasteride 7 upvotes 1 year ago

An 18-year-old experiencing hair loss and seborrheic dermatitis has tried finasteride, dutasteride, and various shampoos without success. They are considering anti-androgens like RU58841 and KX-826 for oil control and dandruff reduction.

community Sulfate in Nizoral vs. Head & Shoulders

in Ketoconazole 6 years ago

The conversation discusses the presence of sulfates in Nizoral and Head & Shoulders shampoos. The user seeks advice on whether to return Head & Shoulders for a sulfate-free alternative and recommendations for a second shampoo/conditioner to alternate with Nizoral.

community Shoutout to Zinc pyrithione and Piroctone olamine

in Product 3 upvotes 1 year ago

Zinc pyrithione and piroctone olamine are effective for reducing hair shedding, possibly more so than ketoconazole. There is a concern about zinc pyrithione shampoo interfering with minoxidil, but it's unclear if this is proven.

community topical finasteride: dissolving finasteride in "alpacin cafeine liquid"?

in Finasteride/Dutasteride 1 upvotes 2 years ago

A user discusses using Alpecin Caffeine Liquid for scalp health and considers dissolving finasteride tablets into it for a DIY topical treatment. They inquire about potential absorption issues with this method.

community Is this hierarchy of topical anti androgens accurate?

in Ketoconazole 8 upvotes 3 years ago

User on fin, minox, and ketoconazole seeks to add another topical anti-androgen. Hierarchy of effectiveness: 1. RU55841, 2. Fluridil - Eucapil, 3. CB-03-01 - Breezula, 4. Ketoconazole; alfatradiol suggested as addition.

community is Oleanic acid a DHT blocker ?

in Treatment 4 upvotes 1 year ago

A user is experiencing hair thinning and is using a peptide with oleanic acid as a DHT blocker, along with minoxidil, while waiting for topical finasteride. They plan to use a combination of minoxidil, finasteride, dermastamp, ketoconazole, and scalp massages, but are advised to stick to proven treatments like finasteride and minoxidil.

community inactive ingredients of Sandoz Finasteride 5mg compared too Proscar and Propecia?

3 upvotes 10 years ago

The conversation discusses the differences in inactive ingredients between Sandoz 5mg Finasteride and Proscar/Propecia, questioning the purpose of certain additives like Docusate sodium. It seeks to determine if these differences affect the effectiveness of the treatment for hair loss.

community Topical fin - why are people still using alcohol carriers when liposomal is proven to be better?

in Treatment 7 upvotes 11 months ago

Liposomal carriers for topical finasteride offer better targeting, reduced side effects, and less irritation compared to alcohol-based solutions, but availability and cost may limit their use. Minoxidil can dissolve in liposomal carriers, enhancing delivery and stability.

community Ru + glycerin making scalp greasy . help !!

in Finasteride/Dutasteride 2 upvotes 1 year ago

The user is experiencing a greasy and dandruff-prone scalp from using RU58841 with glycerin and is seeking alternative carriers for seborrheic dermatitis. They are also using dutasteride 0.5mg.

community Alternative keto shampoo to nizoral?

in Ketoconazole 4 upvotes 1 year ago

The conversation is about finding an alternative ketoconazole shampoo to Nizoral due to its strong smell, with suggestions including Intelligent shampoo and Sons brand. The discussion also touches on the effectiveness of ketoconazole for dandruff and hair loss, with some users recommending prescription options for higher concentrations.

community topical cetirizine to control scalp inflammation

in Treatment 4 upvotes 4 years ago

The user applies a topical solution containing minoxidil, finasteride, dutasteride, retinoic acid, and hydrocortisone to address scalp inflammation and is considering adding cetirizine to the mix. They are calculating the correct amount of cetirizine to add to their formula and have paused this approach to retry oral minoxidil.

community Topical Finasteride with Chitosan: an overlooked solution?

in Finasteride/Dutasteride 5 upvotes 3 years ago

Topical finasteride with hydroxypropyl chitosan shows significantly less serum absorption and minimal DHT reduction compared to oral finasteride. Users need the specific chitosan formulation to avoid side effects seen with regular ethanol+PG solutions.

community piroctone olamine was was very superior than ketoconzole in increasing hairgrowth and reducing itching and danruff?

in Research/Science 15 upvotes 3 years ago

Piroctone olamine is more effective than ketoconazole for increasing hair growth and reducing itching and dandruff. Treatments discussed include Minoxidil, finasteride, and RU58841.

community The New, Improved CB-03-01/Setipiprant Group Buy

29 upvotes 9 years ago

The group buy for CB-03-01, a topical anti-androgen for hair loss, was postponed and refunded due to issues with the product's form and solubility. The product, also known as Breezula, is an alternative to finasteride with fewer side effects, but its official release is delayed until 2021.