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GlossaryAnthralin

medication used to treat psoriasis and sometimes alopecia areata

Anthralin, also known as Dithranol, is a medication commonly used to treat psoriasis and sometimes alopecia areata. It works by slowing down the growth of skin cells and reducing inflammation. While effective, it can cause skin irritation and staining, so it is typically applied under medical supervision.

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community Clascoterone - what we have right now

in Research/Science 23 upvotes 2 months ago

Clascoterone is a topical treatment for androgenetic alopecia, showing modest to moderate hair regrowth, and may be available by 2027-2028. It is considered safer than finasteride, with discussions on its effectiveness compared to RU58841 and pyrilutamide.

community EMA is re-examining Winlevi (clascoterone at lower concentration)

in Treatment 8 upvotes 10 months ago

Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.

community AH-001 another topical AR degrader beside GT20029, completed Phase I

in Research/Science 9 upvotes 6 months ago

AH-001 is a new topical treatment designed to degrade androgen receptors, targeting the root cause of androgenetic alopecia without the side effects of oral treatments like finasteride. It has shown a strong safety profile and good local tolerability in early trials.

community Clascoterone is the way to go if you cannot use DHT blockers

in Chat 7 upvotes 2 weeks ago

Clascoterone is suggested as an alternative for those who experience side effects from finasteride and dutasteride. It is not widely available yet, but some users are obtaining it from compounding pharmacies or suppliers like Echemi.

community Breezula is a good alternative

in Research/Science 4 upvotes 3 weeks ago

Clascoterone 5% solution (Breezula) is a promising alternative for androgenetic alopecia, showing continued hair growth with consistent use and no significant side effects. It may be suitable for those who cannot tolerate finasteride or dutasteride, especially when trying to conceive.

community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 4 upvotes 1 year ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community Clascoterone/ Breezula will it work

in Research/Science 1 month ago

Breezula's effectiveness is uncertain, with some users skeptical about its potential and others noting its recent availability on the grey market. A user reported success with a stack of Dutasteride (oral), Minoxidil (topical), and RU58841 (topical), achieving significant hair improvement after 18 months.

community fluridil (topilutamide) vs. cb-03-01 (clascoterone)

in Research/Science 5 upvotes 2 years ago

The conversation is about comparing the effectiveness of fluridil and clascoterone in preventing hair loss and inquiring about their use as standalone treatments. There is a question about the concentration of the fluridil brand for efficacy.

community Clascoterone 12 months phase 3 result out

in Treatment 42 upvotes 1 month ago

Clascoterone is promising for hair loss, showing 24.5% improvement in satisfaction compared to placebo. Users consider it an alternative to finasteride, with concerns about absorption and side effects.

community How to choose between topical antiandrogen (Pyrilutamide) vs topical Alfatradiol (17α-estradiol) as an add-on treatment?

in Treatment 7 upvotes 6 months ago

The user is considering adding Pyrilutamide or Alfatradiol as a topical treatment for hair loss after oral Finasteride and Dutasteride became less effective. Other users suggest Pyrilutamide for its safety profile, while one user shares positive experiences with RU58841 for reducing scalp itch and improving hairline.

community Clascoterone powder already available?

in Product 4 upvotes 1 month ago

Clascoterone powder is now available, but it's expensive and not widely discussed due to past ineffective results at higher concentrations. Users are skeptical about its effectiveness and are seeking reliable sources.

community Clascoterone 5% Delivers Strong Phase 3 Hair-Growth Results

in Research/Science 364 upvotes 4 months ago

Clascoterone 5% solution shows strong potential for hair growth, offering a new treatment for alopecia with minimal side effects. It blocks androgen receptors locally and may be available by late 2026 or early 2027.

community Clascoterone phase 3 results are out!

in Treatment 80 upvotes 5 months ago

Clascoterone phase 3 results show promising improvements in hair count, but concerns about high costs and lack of detailed data remain. Users compare it to existing treatments like Minoxidil and Finasteride, expressing skepticism about its accessibility and effectiveness.

community Need supplemental products in addition to oral minoxidil and oral dutasteride

in Product 1 upvotes 8 months ago

The user has been using oral minoxidil and dutasteride for hair loss without success and is considering adding topical 17α-estradiol, Pyrilutamide, Clascoterone, or cetirizine. They have confirmed low serum DHT levels and are exploring additional treatments due to genetic sensitivity to DHT and prostaglandin D2.

community Pyrilutamide and RU alternatives?

in Treatment 1 upvotes 1 year ago

Pyrilutamide is officially available for purchase, and users suggest Fluridil as an alternative topical anti-androgen. Some users report positive results with pyrilutamide from Koshine.

community i'm Considering adding hair stimulant: stemoxydine or alphatradiol

in Treatment 5 upvotes 1 year ago

The user is considering adding Stemoxydine to their hair loss regimen, as they already use topical finasteride with rosemary and cannot use Minoxidil. They are seeking feedback on Stemoxydine and Alphatradiol, and another user mentions 2-deoxy-d-ribose as a potential option.

community The urge to buy Clascoterone 5% solution

in Research/Science 11 upvotes 5 months ago

Clascoterone 5% solution is not yet commercially available, with only the 1% solution currently sold for acne. Users discuss the potential of Clascoterone as a hair loss treatment, comparing it to other anti-androgens like RU58841 and Eucapil.

community Anagenic is trying to compound Gt20029

in Treatment 55 upvotes 3 years ago

The conversation discusses concerns that Anagenic's version of GT20029 might not be as effective or safe as Kintor's, with comparisons to issues faced by pyrilutamide. The chemical structure of the drug has been published.

community Alfatradiol!!! Does anyone use this as part of their stack and can actually comment on its effectiveness?

in Treatment 2 upvotes 1 year ago

Alfatradiol is used by some for hair loss, often alongside treatments like finasteride, RU58841, and minoxidil, but its effectiveness is unclear. Some users report no significant improvement, while others note reduced sebum production but experience side effects like gallbladder pain.

community Has anyone tried CB-01-03 aka Clascoterone?

in Research/Science 2 upvotes 2 months ago

Clascoterone, a topical anti-androgen, is generating interest for potentially fewer systemic side effects. Users are curious about its effectiveness and details like concentration and duration of use.

community Anyone used CB-03-01 (clascoterone), is it worth it, too risky??

in Research/Science 2 upvotes 1 year ago

The user experienced side effects from low-dose topical finasteride and is considering using clascoterone (CB-03-01) despite concerns about its risks and cost. They seek advice on its effectiveness and potential side effects compared to other treatments like alfatradiol and fluridil.

community Clascoterone 5% solution infographic

in Update 132 upvotes 5 months ago

Clascoterone 5% solution is discussed as a potential new treatment for hair loss, offering an alternative for those who can't use finasteride or need additional options beyond minoxidil. Concerns about cost, effectiveness, and safety compared to existing treatments like RU58841 and finasteride are highlighted.

community RESULTS: 1% Clascoterone Cream. (3 months Jan-Mar 2026)

in Progress Pictures 14 upvotes 1 month ago

The user reported slight improvement in hairline using 1% Clascoterone cream over three months but found it too costly to continue. They expressed interest in trying a 5% concentration if it becomes available at a reasonable price.

community Can anyone share their experience of using alfatradiol (17α-estradiol; Pantostin/Ell-Cranell etc)?

in Treatment 6 upvotes 1 month ago

The conversation is about using alfatradiol (17α-estradiol) as a hair loss treatment. The user is considering adding it to their regimen due to its safety and availability.

community Kintor Pharmaceutical Announced U.S. FDA Has Greenlighted Phase II Clinical Trial for Pyrilutamide to Treat Androgenetic Alopecia

in Treatment 26 upvotes 4 years ago

Chinese company gets green light for Pyrilutamide Phase II trial for androgenetic alopecia. Androgen receptors downregulate in androgen deficient environments.

community Anyone knows a legitimate online source/distributer of 17α-estradiol (Alfatradiol) powder?

in Treatment 1 upvotes 1 year ago

The conversation is about finding a legitimate online source for 17α-estradiol (Alfatradiol) powder to make a 0.1% solution for hair loss treatment. A user suggests Anagenica as a source.

community Best available SARD right now?

in Treatment 3 upvotes 2 weeks ago

The user is considering RU58841 and has been using dutasteride since age 17. They are seeking affordable SARD options, mentioning ASC-J9, GT20029, and AH001.

community Excited! Just got prescribed Clascoterone 5%

in Treatment 25 upvotes 2 weeks ago

The user is excited about starting Clascoterone 5% for hair loss, a DHT blocker, and expects better results when combined with Minoxidil. The prescription costs $199 for 30 ml or $353 for 60 ml, and the user plans to cover the cost by driving for Uber.

community Does anyone use Fluridil as their anti-androgen of choice?

in Chat 5 upvotes 2 years ago

Fluridil, a non-steroidal anti-androgen approved for alopecia in parts of Europe, is noted for its low side effects but is not commonly discussed. The user is inquiring if anyone prefers it over other anti-androgens like Spiro or RU58841.

community Future hope ? What do you guys predict ? clascoterone, pyrilutamide, gt20029 etc.

in Treatment 15 upvotes 4 years ago

User tried oral finasteride, topical finasteride, topical dutasteride, and RU58841 but experienced side effects. They discuss upcoming treatments like clascoterone, pyrilutamide, gt20029, and KY19382 as potential options.