Korea launched its first OTC oral hairlossdrug, dexpanthenol B5. Users discuss its anti-oxidative and anti-inflammatory effects but note a lack of efficacy studies.
The conversation discusses GT20029, a new topical drug for hairloss and acne without notable side effects, which has been accepted for investigational use in China. Some users express skepticism about the legitimacy of the company and the potential for other drugs like RU58841 to be developed due to patent expiration and lack of profitability.
A Silicon Valley-backed company aims to cure hairloss. Exciting advancements include mRNA therapies, gene editing, hair cloning, AR degraders, anti-androgens, cell-based rejuvenation, and AI-based drug discovery, with hopes for FDA approval of GT20029 within 10 years.
PP405 is a potential hairloss treatment undergoing trials, with discussions on its effectiveness and comparison to existing treatments like finasteride and minoxidil. There is skepticism about its status as a cure, with hopes for future advancements in genetic treatments like CRISPR.
Finasteride users may have an increased risk of depression, anxiety, and suicidal thoughts, though some attribute these issues to hairloss itself. The link between finasteride and mental health effects is debated, with varying user experiences.
A 23-year-old male has been using a regimen including oral Dutasteride, topical Minoxidil, Azelaic acid gel, Ketoconazole shampoo, and microneedling for 4 months with minimal results. Another user suggests that it typically takes a year to see significant effects and encourages him to continue the routine.
Finasteride and dutasteride can cause psychiatric side effects like depression and suicidal thoughts in some users, especially those with a history of mental health issues. While some users experience positive hair growth results, others face severe psychological effects, raising concerns about their safety and the need for careful monitoring.
ABS-201, a prolactin receptor blocker, shows promise in reversing hairloss and graying, with early success in macaques. Current treatments like finasteride, minoxidil, and RU58841 are still widely used, but new options like PP405 are eagerly anticipated.
The conversation discusses the potential connection between baldness, heart disease, and high blood pressure. Treatments mentioned include Minoxidil, Spironolactone, and Finasteride.
Clascoterone 5% and PP405 are being discussed as potential future treatments for hairloss, with clascoterone nearing phase three completion and PP405 possibly taking a cosmetic route to market. Current treatments like minoxidil, finasteride, and RU58841 are mentioned as effective in slowing hairloss, but a complete cure remains elusive.
PP405 is a new hairloss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.
The conversation discusses the availability of Breezula, a drug for hairloss, now being sold as an acne treatment, and whether it can be applied to the scalp. Users express skepticism about new hairloss treatments and suggest waiting for FDA approval.
The conversation is about the effects of steroids on hairloss. Some users believe that steroids can cause hairloss, while others argue that it depends on individual sensitivity to DHT. There is also discussion about the appearance of balding individuals who use steroids.
Saw Palmetto is not effective for hairloss treatment and is not a recommended alternative to finasteride due to its inability to significantly inhibit DHT.
Pyrilutimide and CB-03-01, two treatments for hairloss, have similar clinical trial results despite different binding affinities to androgen receptors. Factors other than binding affinity, like the time a drug stays bound to the receptor, may influence their effectiveness.
Hairloss treatments are generally categorized as anti-androgens, like finasteride and RU58841, which prevent hairloss by targeting DHT, and growth stimulators, such as minoxidil, rosemary oil, microneedling, and LLLT, which promote hair growth by increasing blood flow and growth factors. The user is seeking to confirm these categories and understand if there are other treatments or mechanisms of action.
Minoxidil increases hair count despite high prolactin being linked to hairloss. Blocking DHT is effective, but not always necessary; HMI-115 is a promising treatment for androgenetic alopecia.
The conversation is about someone experiencing continued hairloss despite using Pyrilutamide and considering the need for more time or better quality control for the treatment. Another person suggests waiting for the drug to be officially approved due to potential quality issues with current products.
Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hairloss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.
Medication caused hairloss, which stopped after discontinuing the drugs, but hair hasn't regrown yet. The user is considering seeing a doctor for further advice and possibly using biotin supplements.
Hairloss treatments discussed include Minoxidil, Finasteride, and Spironolactone. One user shares success with Finasteride, Minoxidil, and low-dose Cyproterone Acetate, but warns against long-term use of oral anti-androgens.
Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hairloss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.
A user's experimentation with various hairloss treatments, including medications and topical applications; as well as their desire to experience unusual sensations through the use of drugs.
Hairloss treatments discussed include Minoxidil, Finasteride, RU58841, ass hair transplant, topical Viagra, castration, and transitioning to female. A user mentions an experimental drug called M4U-5 (Mousteride) that turns you into a mouse.
Brian Dye's theory links skeletal malocclusion type II to hairloss, suggesting it's a blood flow issue. Treatments mentioned include minoxidil, finasteride, and anti-inflammatory drugs like benaxoprofen.
Effective treatments for hairloss, including Dutasteride, Finasteride, Minoxidil, Dermarolling, LLLT, PRP, Ketoconazole, and Scalp Massage. In addition, anti-inflammatory diets and stress management are recommended to maintain or regrow hair.
Kintor Pharmaceutical's KX-826 shows promising results for hairloss treatment. Users discuss the use of anti-androgens like spironolactone and RU58841, noting concerns about concentration and safety.
A 25 year old male who has been using finasteride and dutasteride for two years to treat his hairloss, with no success. Other treatments such as oral minoxidil, topical anti-androgens, RU58841, latanoprost, topical estrogen, CB 03 01, microneedling, keto 2% shampoo, vitamin D, Omega 3, B vitamins and probiotics were discussed.
New hairloss treatments like GT20029, Clascoterone, and PP405 are being discussed, with concerns about how to apply multiple topicals alongside existing treatments like minoxidil and finasteride. Suggestions include creating a routine, mixing treatments, or minimizing redundancy in treatment stacks.
The conversation lists hairloss treatments including finasteride, dutasteride, RU58841, pyrilutamide, breezula, and fluridil, and suggests ketoconazole as another option. Some users warn against using certain treatments like cyproterone acetate, bicalutamide, and spironolactone due to their strong anti-androgen effects and potential impact on masculinity.