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      community The story of RU58841/PSK3841

      in Research/Science 1 year ago
      RU58841, an anti-androgenic compound, showed early promise for treating alopecia but faced challenges after its patent in 1997. Despite advancing to Phase II trials, safety concerns and financial struggles led Aventis to abandon its development. Proskelia, which later merged into ProStrakan, couldn't prioritize the drug, leading to its eventual stagnation and failure to reach the market.

      community Topical Saw Palmetto for hair growth

      in Treatment  5 upvotes 5 years ago
      Topical saw palmetto is discussed as a mild anti-androgen for hair growth, with some users combining it with other treatments like spironolactone and ketoconazole shampoo. Users share mixed experiences, with some not noticing regrowth and others hopeful for positive results.

      community FOL005 claims it's better than Finasteride and Minoxidil.

      in Technology  185 upvotes 1 year ago
      FOL-005 claims to be more effective than Minoxidil and Finasteride but lacks anti-DHT properties, leading to potential reduced efficacy over time. Concerns are raised about misleading marketing and the safety of alternative treatments like Pyrilutamide and Clascoterone.

      community Topical Serenoa? Anyone tried it?

      in Treatment  2 upvotes 2 months ago
      The conversation discusses using topical serenoa oil, a natural anti-DHT treatment, for hair loss. It is considered less effective than finasteride and dutasteride but can be added to a routine with topical minoxidil.

      community Severe diffuse thinning after scalp inflammation – should I keep fighting or just accept it?

      in Finasteride/Dutasteride  4 upvotes 6 months ago
      A 23-year-old experiencing severe diffuse thinning after scalp inflammation is considering finasteride as a last resort after stopping minoxidil and using anti-inflammatory medication. Users suggest that inflammation causes temporary shedding and recommend consulting a dermatologist, with some advocating for finasteride as a reliable treatment option.

      community Does ketoconazole reduce systemic DHT by much?

      in Treatment  6 upvotes 10 months ago
      Ketoconazole shampoo does not significantly reduce systemic or scalp DHT levels and is mainly used for its anti-fungal and anti-inflammatory effects. It is not a replacement for finasteride, which is recommended by some users despite concerns about side effects.
      Advice needed regarding hair treatment

      community Advice needed regarding hair treatment

      in General  100 upvotes 10 months ago
      A 22-year-old male is experiencing hair loss and has been using topical minoxidil and anti-dandruff shampoo for six months without improvement. Suggestions include adding finasteride to the routine and considering treatments for potential scalp issues like seborrheic dermatitis.