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      community [Serious] Experience with grey-market KX-826 (Pyrilutamide)

      in Research/Science  2 upvotes 2 years ago
      The user experienced reduced hair loss using grey-market KX-826 alongside Minoxidil foam, achieving better results with Minoxidil liquid but restricted to foam due to an allergy. Initial side effects included shortness of breath, racing heart, and dizziness, which subsided after the first week.

      community Before and after of 20 months of fin and min

      in Progress Pictures  125 upvotes 2 months ago
      The user experienced worsening hair thinning despite using finasteride, minoxidil, and ketoconazole shampoo, and switched to dutasteride five months ago. They are considering adding tretinoin and microneedling to their routine for better results.

      community Killing the Norwood Reaper, a Journey

      in Progress Pictures  370 upvotes 2 years ago
      The user is treating hair loss with a regimen including Dutasteride, oral and topical Minoxidil, microneedling, and various supplements for overall health. They are considering adding tretinoin, stemoxydine/RU, DIM, Boron, and Fadogia Agretis to their routine.

      community Going to report on my Pyrilutamide progress

      in Progress Pictures  9 upvotes 3 years ago
      The user stopped using finasteride due to side effects and began treatment with Pyrilutamide, while continuing minoxidil, topical melatonin, dermarolling, and Nizoral. They had a second hair transplant to improve their frontal hairline and will report back on the results of the new treatment regimen.

      community Nest topical compound stack to fight hair loss

      in Treatment  1 upvotes 2 years ago
      The user is seeking advice for the best topical treatment to combat their ongoing hair loss, despite already using oral dutasteride, RU-58841, and minoxidil. They are considering adding CB-03-01 or topical Spiro to their regimen to lower testosterone levels at the follicles.

      community Is pyrilutamide safe to use or still unknown?

      in Research/Science  12 upvotes 3 years ago
      The conversation is about the safety and effects of using pyrilutamide for hair loss. One person reported severe negative effects, another experienced minor side effects without much benefit for hair, and a third found the anecdote helpful in making a decision.

      community Pyrilutamide users, any updates?

      in Treatment 3 years ago
      Treatment for hair loss, including Pyrilutamide, Minoxidil, Finasteride, and RU58841; with some users reporting success in growing vellus hairs.

      community After a life of long hair , I chopped it off.

      in Shaved/buzzed  9 upvotes 2 years ago
      The conversation is about someone starting treatment for hairline thinning with 1mg finasteride, 5% minoxidil, and vitamin D3 supplements, and asking for advice on dermarolling. Another person reassures them that they still have a lot of hair and could maintain or regrow hair with the treatment.

      community Interpreting pre-finisteride blood panels

      in Chat  2 upvotes 11 months ago
      The conversation is about someone planning to start finasteride for hair loss and wanting to interpret pre-treatment blood panels to assess the risk of side effects like gynecomastia. They list various tests to measure hormone levels and other health indicators.

      community What I've been dealing with, so far.

      in Female  8 upvotes 1 year ago
      A female in her late 30s experienced hair thinning due to health issues and treatments, including antibiotics and stress. She started using minoxidil, biotin, and vitamins from **hers** and is currently dealing with shedding and possible weight gain.

      community Oral minoxidil - how important is dermastamping?

      in Microneedling 5 months ago
      A trans woman is using 10 mg oral minoxidil, dutasteride, and estradiol for hair regrowth and is also doing dermastamping despite the pain. Users discuss the benefits of dermastamping for serum absorption and hair follicle stimulation, with some expressing surprise at the high minoxidil dosage.

      community Just a reminder not everything is about dht blockers and why vitamins are important

      in Progress Pictures  68 upvotes 9 months ago
      The conversation discusses the impact of vitamins, stress reduction, and appropriate shampoo on hair health, with the original poster noting slight improvements after two months of using vitamins B5, B6, zinc, and a suitable shampoo. Many users express skepticism about the effectiveness of vitamins for hair loss unless there is a deficiency, emphasizing the importance of addressing DHT and considering 5AR inhibitors.

      community Have some questions about prescription I got from a trichologist

      in Chat  1 upvotes 1 year ago
      A trichologist prescribed Biotrade Sebomax HR Anti-Hair Loss Tonic, Spectral DNC-N Nanoxidil, Hairfollic Him/Man Vitamins, and Bosley MD DHT blocking supplements instead of finasteride due to potential risks at age 21. The user questions the legitimacy of the treatment and considers seeking a second opinion.

      community PP405 Update and My Take on Pelage

      in Research/Science  86 upvotes 6 months ago
      Pelage Pharmaceuticals raised $120M for their hair loss treatment, PP405, showing strong investor confidence despite limited data. There is skepticism about its efficacy and long-term effects compared to treatments like GT20029.

      community questions for the pyrilutamide users here

      in Treatment  7 upvotes 3 years ago
      The conversation discusses the storage and use of pyrilutamide for hair loss, where one user advises against keeping it in the freezer as it may crystallize the active compounds.

      community discouraged about pyrilutamide

      in Research/Science  11 upvotes 3 years ago
      Discouragement regarding Pyrilutamide, a drug in development for hair loss, and the potential side effects of Finasteride. People discussed anecdotal experiences with Pyrilutamide as well as suggestions to wait out Phase 3 trials before making any conclusions.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Best brand of topical melatonin?

      in Product  8 upvotes 3 years ago
      People are using topical melatonin for diffuse thinning and retrograde alopecia. They are discussing the best brands and application methods.

      community applying tretinoin and SPF on scalp?

      in Treatment  1 upvotes 1 year ago
      The conversation discusses using tretinoin for hair loss and whether applying SPF on the scalp is necessary if hair covers the treated areas. The user is considering this treatment despite having no completely bald patches.