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TDM-105795 showed promising hair growth results, with higher efficacy than placebo and minimal side effects. It activates dormant hair follicle stem cells and may maintain gains without immediate loss, unlike minoxidil.

The user started using oral minoxidil and estradiol in August 2025, added finasteride in December, and experienced significant hair shedding in February/March. They switched to estradiol injections and are considering their hair washing routine, while another user suggested consulting a dermatologist and possibly trying dutasteride.

The discussion revolves around the frequency of applying topical finasteride for hair loss treatment. The main question is whether applying it every 4-5 days could still be effective, given that its half-life in the scalp tissue is 5-6 days.

The user experienced a significant drop in libido and erectile issues after increasing their finasteride dosage, combining oral and topical treatments. They plan to take a break and resume using a lower concentration of topical finasteride to manage side effects.

The user experienced hair regrowth with finasteride and minoxidil but faced shedding after stopping the treatment. They resumed the treatment and used Toppik hair fibers to mask hair thinning during the shedding phase.

User tries dermapen for hair loss and plans to use non-mainstream topicals like c60, ghk-cu, and ptd-dbm with valproic acid. They also use a head massager and modified LLLT belt for additional treatment.

The user increased their dutasteride dose from 0.5mg to 3mg daily to address hair thinning, noticing a change in shedding patterns and possibly thicker hair. Other users discuss the effectiveness of different dutasteride doses on DHT levels and suggest staying consistent with the treatment.

The user discusses switching from multiple vitamins to a single multivitamin pill. They also mention using oral finasteride and topical minoxidil with finasteride for hair loss treatment.

AMP-303 and AMP-601 are new hair loss treatments targeting dermal papilla cells, with AMP-303 showing early efficacy in transitioning vellus hairs to terminal hairs after one injection. Further clinical trials are planned, and these treatments are seen as promising due to their biologic approach and less frequent application compared to daily treatments.

The conversation discusses Fevipiprant, an asthma drug that may block CRTH2 and potentially stop male pattern baldness (MPB) without inhibiting DHT. It also mentions the use of finasteride and dutasteride for hair loss.

User shares 2-month progress with fin, min, dermarolling. Others discuss consistency, regrowth, shedding, and potential side effects.

PP405 is a potential new hair loss treatment that might replace finasteride and minoxidil, but it is still in clinical trials and may not be available until 2028-2031. There is skepticism about its effectiveness, with only a 20% increase in hair density observed in some participants.

A user shared their experience with DIY PRP scalp injections for hair regrowth, using an EZ Injector and other at-home equipment. Another user reported success with at-home PRP treatments for 1.5 years, noting thicker hair and a stable hairline.

A user who initially had positive results with oral finasteride, topical minoxidil, and microneedling for hair loss, but experienced side effects like fog and depression. After stopping and losing progress, they restarted with topical treatments and microneedling, reporting good results and no side effects.

Breezula (clascoterone) initially performed better than finasteride for hair loss but then effectiveness decreased almost back to baseline after 6 months, raising questions about its strength.

The conversation is about using topical valproic acid (VPA) for hair loss, focusing on its application method, usage frequency, and combination with other treatments like micro-needling. No specific experiences with VPA were shared.

The conversation is about comparing hair loss treatments Pyrilutamide (KX-826) and CB-03-01, discussing their cost, side effects, and effectiveness. The user questions whether to try CB-03-01, which is more expensive and potentially less effective, or switch to the cheaper and possibly better Pyrilutamide.

The user has been using 0.5 mg oral finasteride and recently switched to 2.5 mg oral minoxidil from topical application. They are observing potential early regrowth with longer baby hairs.

Kintor Pharma successfully dosed the first patient in a Phase II trial for KX-826 for acne vulgaris. Users are more interested in results for male pattern baldness (MPB).

The user experienced a sudden and severe hair loss after 1.5 years of successful treatment with finasteride and minoxidil. They plan to check their thyroid and vitamin D levels as potential causes.

The user experienced side effects from daily finasteride and reduced the dosage to 0.25mg twice a week while continuing minoxidil. They are considering topical anti-androgens but are concerned about application difficulties and potential side effects.

A user reported increased shedding and some side effects like ball ache and potential watery semen after taking 0.25mg of finasteride daily for two months, but noted a high sex drive and considered the shedding a possible sign of new hair growth. Other users discussed dosage differences, with some suggesting starting with a smaller dose and monitoring effects, while others shared their experiences with no shedding or hair growth yet.

Pyrilutamide 1% is being used for hair loss, with some users experiencing shedding but no regrowth yet. It may be too early to see results.

Stopping finasteride due to side effects and family planning can lead to temporary increased hair shedding, which may stabilize over time. Consider topical treatments or a lower dose after addressing current concerns.

The user had a failed hair transplant in 2018, didn't use medication, and experienced severe depression from further hair loss. They started treatment in 2022 with 0.5mg daily finasteride, 2.5mg oral minoxidil, 1ml daily topical minoxidil, and are considering low dose RU58841 and dermarolling.

A user is waiting for pyrilutamide delivery and is seeking reviews, especially regarding side effects. No reviews have been mentioned in the conversation.

The user completed their first month using oral finasteride and topical minoxidil without issues but is concerned about a 2-3 day gap in their finasteride supply affecting progress. They are also seeking advice on obtaining a multi-month supply.

The post discusses a 21-year-old male's significant hair regrowth after experiencing shedding periods during an 11-month treatment with finasteride, minoxidil, ketoconazole, biotin, and dermaroller. The conversation encourages persistence with the treatment despite shedding phases, as hair tends to grow back thicker and longer.

PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

Breezula passed a clinical trial in August and there are questions about its availability in 2021 and potential delays due to Covid. No specific treatments were discussed.