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      community Selling a premixed KY19382 solution

      in Research/Science  7 upvotes 4 years ago
      The conversation discusses the sale of a premixed KY19382 solution for research purposes, highlighting previous unsuccessful group buys and the formulation process. Prices and purchasing options for KY19382 solutions and powder are provided.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community What is worth dissolving in topical minoxidil solution?

      in Treatment  3 upvotes 1 year ago
      Switching from minoxidil foam to topical solution and considering adding caffeine, melatonin, or cetirizine. Currently using 2.5mg oral minoxidil and 1mg oral finasteride, planning to ask for 0.5mg oral dutasteride and 5mg oral minoxidil.

      community A warning to anyone considering 3rd party sourcing PP405 or its analogs

      in Treatment  31 upvotes 2 months ago
      Be cautious when sourcing PP405 or its analogs from third-party suppliers due to potential safety risks and lack of regulatory approval. The conversation highlights concerns about counterfeit products and the absence of reliable testing, making it risky to use such treatments.

      community Megadosing Koshine826(Pyrilutamide), my Plan.

      in Treatment  1 upvotes 1 year ago
      The user plans to use 1% Koshine826, 0.1% Alfatradiol, Minoxidil with Tretinoin, microneedling, and Stemoxydine for hair loss treatment. They expect significant recovery with this regimen.

      community KX-826 Pyrilutamide1% coming soon

      in Update  152 upvotes 1 year ago
      KX-826 Pyrilutamide 1% is launching soon, and users are discussing its potential benefits and drawbacks compared to other treatments like Minoxidil and finasteride. Some users are skeptical about its effectiveness, while others are hopeful it will be a safer alternative.

      community Breezula CB-03-01

      in Treatment  11 upvotes 6 years ago
      The conversation is about a potential new hair loss treatment called Breezula CB-03-01. Users are discussing updates on its development and sharing personal experiences with making or using it.

      community Reasonable and safe stack? Bloodwork within.

      in Minoxidil  1 upvotes 2 years ago
      A 26-year-old male is using a combination of clomiphene, minoxidil, tadalafil, bupropion, and lisdexamfetamine to address low testosterone, ED, depression, and focus issues. He seeks input on the safety and efficacy of this regimen, which also includes magnesium, zinc, and fish oil supplements.

      community Broccoli supplement (Sulforaphane) for better Minox results?

      in Minoxidil  4 upvotes 3 years ago
      Broccoli or sulforaphane supplements are unlikely to improve Minoxidil results due to the need for an unrealistically large dose. Tretinoin, micro-needling, and low-dose oral Minoxidil may be more effective for those lacking the necessary enzyme in the scalp.

      community Breezula phase 3 results said to be released next month

      in Product  27 upvotes 1 year ago
      Breezula's phase 3 results are expected soon, with discussions on the effectiveness of androgen receptor antagonists like spironolactone and the potential of GT20029. Users express skepticism about new treatments and discuss the complexities of male pattern baldness, often relying on finasteride despite its side effects.

      community Is this solution unnecessarily aggresive?

      in Product  2 upvotes 5 months ago
      The solution contains minoxidil, finasteride, azelaic acid, caffeine, retinoic acid, and procapil. Users suggest minoxidil with tretinoin and a 5-alpha reductase inhibitor, while dismissing retinoic and azelaic acids as unnecessary.

      community Using Topical Minoxidil And Pyrilutamide Together

      in Treatment  1 upvotes 1 year ago
      Mixing 1ml of topical Minoxidil and Pyrilutamide (2ml total) together in a container and applying immediately is being discussed. The concern is whether this method degrades or compromises the efficacy of either compound.

      community zinc + copper with finastetide/dutasteride?

      in Finasteride/Dutasteride  1 upvotes 3 years ago
      Taking zinc and copper may offset copper depletion and potentially aid hair health when used with finasteride. The user is considering whether to use these supplements alongside finasteride or wait until switching to dutasteride.

      community Just started Dut+Mim, should I add RU58841?

      in Treatment  1 upvotes 5 months ago
      A 23-year-old started using 0.5mg Dutasteride and 2.5mg Minoxidil daily for hair loss and is considering adding RU58841 or GHK-cu. Users suggest waiting a few months before adding anything and mention Koshine's kx-826 as a potentially better alternative to RU58841.

      community Thoughts on this procyanidin B2 supplement?

      in Product  5 upvotes 3 years ago
      User found 15% procyanidin B2 supplement and asks if it's legit. Recommended dosage is 400-600mg daily, similar to study, and user wonders if it's effective for hair loss.

      community What to dilute Finasteride with?

      in Treatments  65 upvotes 11 months ago
      Diluting finasteride in a Hims spray can be done using ethanol or propylene glycol to maintain the desired concentration without increasing minoxidil levels. This approach ensures the finasteride concentration is reduced to 0.025% without affecting the minoxidil strength.

      community How is this looking on around day 80 and question

      in Progress Pictures  2 upvotes 4 months ago
      The user is experiencing negative side effects from a hair loss treatment containing finasteride and minoxidil due to high vitamin B6 content and plans to switch to separate pills without unnecessary vitamins. Another user suggests using a version without B6, noting similar symptoms from finasteride.

      community is mixing finasteride in 2% minoxidil solution a good idea?

      in Treatment  1 upvotes 2 years ago
      The user experiences severe headaches from 5% minoxidil and is considering mixing finasteride with a 2% minoxidil solution or diluting a 5% minoxidil + 0.1% finasteride solution. They seek advice on the appropriate method and dilutant composition.

      community Recommend biotin supplement with saw palmetto

      in Product  1 upvotes 6 months ago
      The conversation is about recommending a biotin supplement that includes saw palmetto and possibly copper for hair loss. The user is seeking suggestions for these specific ingredients.