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GlossaryBlaschko's lines

invisible skin patterns from embryonic cell migration

Blaschko's lines are invisible patterns on human skin that become apparent in certain skin conditions or diseases. These lines represent the pathways of embryonic cell migration and are typically V-shaped on the back, S-shaped on the abdomen, and wavy on the head and extremities. They are not usually visible under normal conditions but can become evident in disorders like lichen planus or epidermal nevi.

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community A new study by Deng and colleagues set out to explore differences between balding and non balding scalps...

in Research/Science 39 upvotes 4 years ago

Balding scalps have more androgen receptors, leading to increased TGF-beta, which causes blood vessel loss and hair follicle miniaturization. Blocking androgen signaling and TGF-beta may help prevent hair loss.

community Does anyone have the removed Breezula phase II 12 month baseline comparison results?

in Research/Science 8 upvotes 5 years ago

The conversation discusses the removal of Breezula phase II 12-month results by Cassiopea and the search for the original data. Concerns were raised about potential negative long-term effects on hair growth, such as androgen receptor upregulation.

community The theory that explains everything. The malloclusion theory has been proven.

in Research/Science 27 upvotes 2 years ago

Brian Dye's theory links skeletal malocclusion type II to hair loss, suggesting it's a blood flow issue. Treatments mentioned include minoxidil, finasteride, and anti-inflammatory drugs like benaxoprofen.

community Hair line Mount Rushmore. Bastards lol.

in Chat 851 upvotes 5 months ago

Hairlines and hair loss treatments like finasteride and hair transplants. Celebrities' hairlines are discussed, noting genetics and interventions.

community Are these new follicle?

in Finasteride 58 upvotes 1 year ago

The user is questioning if black points on their scalp are new hair follicles. They are using finasteride and minoxidil for hair growth.

community ABS-201 KOL Seminar: Dr. Ralf Paus on Human Ex Vivo Hair Regrowth Data

in Research/Science 15 upvotes 4 months ago

ABS-201 shows promise for male hair regrowth by blocking the prolactin receptor, with higher expected efficacy than current treatments. The discussion also covers dosing differences between macaques and humans for hmi115, highlighting a significant dosage disparity.

community Track hairline of Pelage executives

in Research/Science 39 upvotes 6 months ago

Pelage executives' hairlines were discussed, with speculation about them using PP405 for hair regrowth. Concerns were raised about using untested drugs, with some suggesting executives might not risk using them without safety data.

community Mature hairlines in general and defining them

in Chat 13 upvotes 4 years ago

A "mature hairline" is subjective and may not indicate future stability. Finasteride and minoxidil are suggested treatments for hair loss.

community Hair Multiplication Projects in China - Promising clinical trial results on Mice

in Technology 37 upvotes 11 months ago

A breakthrough in hair follicle cultivation using induced pluripotent stem cells (iPSCs) has been achieved, producing large hair follicles suitable for transplantation. Clinical trials for this hair multiplication technology are planned in partnership with Yinguan Biotechnology.

community What do you think of these hair transplants?

in Transplants 304 upvotes 5 months ago

Hair transplants in Bangkok are praised for their natural appearance, with a zigzag hairline design being favored over straight lines. The clinic Hairtran and Dr. Patty receive positive feedback, though some users express skepticism about photo filters and the authenticity of results.

community Masseter Muscles and the Tension Theory of Baldness

in Treatment 5 upvotes 5 years ago

The conversation discusses the tension theory of baldness, suggesting that over-developed masseter muscles may harm hair follicles. Botox injections to relax these muscles reportedly led to an 18% increase in hair count in men with AGA.

community Thoughts on scalp/hairline tattoos's ?

in Chat 15 upvotes 1 month ago

Scalp tattoos can look good but often appear artificial, especially in sunlight or up close, and require regular maintenance. They may boost confidence if done well, but opinions vary on their effectiveness and natural appearance.

community If bloodflow, and scalp tightness is cope why does scalp Botox produce results?

in Chat 4 upvotes 1 month ago

Scalp Botox may help hair loss by relaxing muscles and increasing blood flow, potentially benefiting conditions other than androgenetic alopecia. DHT affects hair follicles differently, causing tension and hair loss in some areas but not others.

community Koshine826 - LX-826? machine translation of the news article

in Product 5 upvotes 1 year ago

KOSHINE826 is a new anti-hair loss and hair growth solution that claims to effectively control oil, reduce hair fall, and promote real hair growth. It targets androgenetic alopecia by inhibiting DHT and has shown promising results in clinical trials.

community Ronaldo and his Brothers Hairline (10 years difference)

in Chat 498 upvotes 1 year ago

Ronaldo's hairline remains sharp, while his brother's is receding. Opinions vary on whether Ronaldo uses treatments like finasteride or has had hair transplants, with some attributing his hairline to genetics and others to possible medical interventions.

community Expectations control for SCUBE3

in Research/Science 21 upvotes 2 years ago

SCUBE3, a protein linked to hair growth in moles, was discovered over 25 years ago and is being developed by Amplifica for potential hair loss treatment. Concerns exist about SCUBE3's association with cancer, as it is a protein that promotes cell growth, which could potentially trigger cancer development if used for hair growth therapy.

community Breezula phase 3 results said to be released next month

in Product 27 upvotes 1 year ago

Breezula's phase 3 results are expected soon, with discussions on the effectiveness of androgen receptor antagonists like spironolactone and the potential of GT20029. Users express skepticism about new treatments and discuss the complexities of male pattern baldness, often relying on finasteride despite its side effects.

community Shiseido filed for this patent in May 2019. Let's get some big brain discussion on this.

4 upvotes 6 years ago

The conversation discusses a patent filed by Shiseido for cloning Dermal Papilla (DP) cells to treat hair loss. The method involves using viral vectors to maintain the cells' growth-inducing properties, differing from Replicel's approach with Dermal Sheath Cup (DSC) cells.

community KX-826 Phase II Results Just Dropped (Male AGA) – Key Takeaways

in Research/Science 15 upvotes 9 months ago

KX-826 Phase II results show that a 0.5% concentration performs better than 1% for treating male pattern baldness. Concerns about receptor upregulation from long-term DHT antagonism were mentioned.

community New baby hairs are popping out. Question though: what are these black dots on hairline? Clogged pores?

in Finasteride/Dutasteride 39 upvotes 9 months ago

The user is experiencing new hair growth after using oral dutasteride, topical minoxidil, and microneedling, but is concerned about black dots on the hairline, which might be clogged pores or dormant follicles. The user previously used a topical minoxidil/finasteride spray and had good results, despite a shedding phase after switching treatments.

community Is trichogram a good thing for testing genetic hair loss

in Research/Science 2 upvotes 2 months ago

A dermatologist checked for hereditary hair loss using blood tests and plans to perform a trichogram. The user had slightly low Vitamin D3 levels, and the trichogram may help confirm androgenetic alopecia.

community Dr. Bloxham's Verteporfin Trial

in Research/Science 29 upvotes 2 years ago

Dr. Bloxham's trial is testing verteporfin on hair transplant patients to see if it can improve hair regrowth in treated areas. People are discussing the potential for follicle regeneration, expected results timeline, and concerns about side effects like cancer.

community Chinese reseachers successfully create hair follicles in-vitrofor autologous transplantation in vivo

in Research/Science 27 upvotes 10 months ago

Chinese researchers have successfully created hair follicles in vitro, potentially offering unlimited hair for transplantation and a cure for hair loss. They plan to test these follicles in vivo on human scalps.

community blood flow and scalp tension - put up or shut up

in Chat 31 upvotes 7 months ago

The conversation discusses skepticism about the effectiveness of scalp tension theory and scalp massagers for hair regrowth, contrasting it with treatments like finasteride and minoxidil, which have more user-reported results. Participants question the belief in scalp tension theory, suggesting it may be a marketing tactic, while others argue for a multifactorial approach to hair loss.

community What regimen do I need to get this hairline?

in Satire 362 upvotes 3 years ago

Discussing a regimen to improve the user's hairline, with treatments proposed including minoxidil, rectal microneedling, IV drip of minoxidil, laser removal, PRP injection, topical minoxidil, divine protein shakes, stem cell injections, and keto shampoo.

community Hair follicle neogenesis

5 upvotes 10 years ago

A user plans to experiment with creating new hair follicles using methods like derma rolling, applying lithium chloride, tannic acid, and various other substances including caffeine, ketoconazole, and raspberry ketones. They also consider using anti-inflammatories, immunosuppressants, and DHT inhibitors to potentially improve results.

community Published in Nature: Osteopontin, a protein involved in the growth of hair on moles could be the key to our troubles.

in Research/Science 12 upvotes 2 years ago

Osteopontin, a protein involved in hair growth on moles, may help with hair loss. However, it is also linked to Alzheimer's, cancer, and bone development, so caution is advised.

community MCL1 does anyone knows anthying about it

in Research/Science 9 upvotes 1 year ago

MCL-1 protein may help maintain hair follicles in the growth phase and prevent miniaturization. There is interest in experimental treatments like exosomes, peptides, or stem cell serums to upregulate MCL-1 for hair loss, especially for those not using minoxidil or finasteride.

community Han Bio Planning Hair Multiplication Trial This Year?

in Technology 6 upvotes 5 years ago

Han Bio plans to start clinical trials for a new hair multiplication technology this year, which could significantly reduce the cost and time of hair transplantation. The technology uses a single hair strand to cultivate enough cells for 30,000 hair strands.

community Breezula 6 Month Topline Phase III Results Released

in Research/Science 173 upvotes 5 months ago

Breezula shows promising hair growth results, with up to 539% increase in hair count compared to placebo, and regulatory submissions are planned in the US and EU. Users are cautiously optimistic, noting the potential for Breezula to replace finasteride by targeting DHT without systemic effects.