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      community Breezula(CB)Phase3Results Date

      in Research/Science  7 upvotes 1 year ago
      Breezula's phase 3 results are expected in July or August, with commercialization possibly in two years. There are concerns about delays and effectiveness, and the cost may be high.

      community Finasteride solution changing colors

      in Finasteride/Dutasteride  1 upvotes 1 week ago
      A user noticed a color change in their hair loss solution containing minoxidil, finasteride, retinoic acid, and hydrocortisone after storing it for several months. They are concerned about the effectiveness of the solution due to potential oxidation.

      community Mixing topical minoxidil and alfatradiol

      in Treatments  39 upvotes 9 months ago
      Mixing minoxidil and alfatradiol in one bottle may affect their effectiveness due to potential stability issues. It's recommended to apply them separately for full benefits.
      The story of RU58841/ PSK3841

      community The story of RU58841/ PSK3841

      in Research  622 upvotes 1 year ago
      RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.

      community Predicted Breezula format? (liquid/cream/foam etc)

      in Treatment  10 upvotes 6 years ago
      The conversation is about the potential format of Breezula, a hair loss treatment, and concerns that it might be greasy or sticky. Specific treatments mentioned are Minoxidil, finasteride, and RU58841.

      community Thoughts on new drug PP405? Already reached phase 2

      in Research/Science  28 upvotes 10 months ago
      PP405 is a new drug in Phase 2 trials for hair loss, generating cautious optimism among users. Some users are currently using finasteride and experiencing side effects, while others are skeptical about unapproved products being sold.

      community Update on PP405 Trails - Pelage

      in Research/Science  14 upvotes 2 months ago
      The conversation discusses interest in participating in PP405 trials for hair loss treatment, with users expressing uncertainty about eligibility due to location. Participants are eager for updates and willing to pay for shipping if trials are limited to America.

      community Pyrilutamide solution question

      in Research/Science  8 upvotes 3 years ago
      The conversation is about the stability of pyrilutamide in different solutions. The user is asking if a 70/30 ethanol/pg solution with 4% water will degrade pyrilutamide.

      community What do you mix your RU58841 powder with?

      in Product  1 upvotes 1 year ago
      RU58841 powder is mixed with a 70% ethanol and 30% propylene glycol solution, with some users seeking PG-free alternatives. Minoxidil is also mentioned as a treatment option.

      community Solution vehicle used by compounding pharmacy

      in Research/Science  1 upvotes 2 years ago
      The user is using 0.1% dutasteride, 1% minoxidil with 2% procapil and 0.005% caffeine in the morning, and 1% minoxidil with 2% procapil and 0.01% tretinoin at night. They are concerned about the solution vehicle's effectiveness in preventing systemic absorption and ensuring the products stay around the hair follicles.

      community Put P5P in my shampoo, reduced itch a lot!

      in Chat  4 upvotes 3 years ago
      The user added P5P (vitamin B6) to their shampoo to reduce scalp itch, which improved significantly. They have been using finasteride for hair loss but are exploring additional treatments like topical antiandrogens and prolactin inhibitors.

      community I want to attempt to use the MPC inhibitor JXL-069

      in Research/Science  14 upvotes 1 year ago
      The conversation discusses skepticism about group buys for hair loss treatments, highlighting issues with unverified chemicals and the risks involved. It suggests stabilizing with dutasteride and minoxidil, and considering a hair transplant instead of experimenting with untested products.

      community fluridil (topilutamide) vs. cb-03-01 (clascoterone)

      in Research/Science  4 upvotes 2 years ago
      The conversation is about comparing the effectiveness of fluridil and clascoterone in preventing hair loss and inquiring about their use as standalone treatments. There is a question about the concentration of the fluridil brand for efficacy.

      community Shedding on pyri (KX-826) is this normal?

      in Update  8 upvotes 1 year ago
      A user experienced increased shedding after adding KX-826 to their long-term finasteride and minoxidil regimen. Another user reported mild side effects from KX-826, such as stomach and testicle pain.

      community 6 months before and after pics: VDPHL01 (oral minoxidil)

      in Progress Pictures  111 upvotes 1 year ago
      A user shared their positive experience with a clinical trial for a new oral medication, VDPHL01, which is a reformulated version of oral minoxidil taken at a high dose of 17mg daily, showing significant hair regrowth after six months. The user noted that this formulation is believed to be more effective and time-released, with fewer side effects compared to regular oral minoxidil.

      community PP405 could be released before GTA 6

      in Chat  133 upvotes 4 months ago
      PP405 is discussed as a potential hair loss treatment, but its effectiveness and safety are uncertain. Some users express skepticism, while others are hopeful, comparing it to existing treatments like Minoxidil and Finasteride.

      community Big 3 + dermaroller update

       213 upvotes 6 years ago
      A user's experience with the Big 3 (minoxidil, finasteride and RU58841) hair loss treatment along with dermarolling. The dermaroller pin was 1.5mm used once per week and drew some blood but not a lot.

      community Breezula 6 Month Topline Phase III Results Released

      in Research/Science  172 upvotes 4 months ago
      Breezula shows promising hair growth results, with up to 539% increase in hair count compared to placebo, and regulatory submissions are planned in the US and EU. Users are cautiously optimistic, noting the potential for Breezula to replace finasteride by targeting DHT without systemic effects.

      community What has the evidence been on side effects with CB?

      in Research/Science  4 upvotes 5 years ago
      Clascoterone (CB) shows an excellent safety profile with no serious side effects, but its effectiveness may decline after six months, making it more suitable as an adjunct treatment with finasteride and minoxidil rather than a standalone solution. Some argue it could be better than finasteride due to its protection against testosterone, but its long-term efficacy remains debated.