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GlossaryBupropion

medication used to treat depression and aid smoking cessation

Bupropion is a medication primarily used to treat depression and to support smoking cessation. It works by inhibiting the reuptake of norepinephrine and dopamine, which are neurotransmitters involved in mood regulation and reward pathways. Commonly known by brand names such as Wellbutrin and Zyban, it is also sometimes prescribed off-label for conditions like ADHD and seasonal affective disorder.

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community Reasonable and safe stack? Bloodwork within.

in Minoxidil 1 upvotes 2 years ago

A 26-year-old male is using a combination of clomiphene, minoxidil, tadalafil, bupropion, and lisdexamfetamine to address low testosterone, ED, depression, and focus issues. He seeks input on the safety and efficacy of this regimen, which also includes magnesium, zinc, and fish oil supplements.

community Has anyone successfully tapered off finasteride?

6 upvotes 10 years ago

A user is considering tapering off finasteride due to concerns about long-term side effects and cost, and is exploring alternatives like zinc and saw palmetto. Their current regimen includes finasteride, Adderall, zinc, bupropion, fish oil, baby aspirin, Rogaine foam, and ketoconazole shampoo.

community 4 months, oral min fin, chewable

in Is this regrowth? 428 upvotes 1 year ago

The user experienced hair regrowth using a chewable combination of oral minoxidil and finasteride without side effects, unlike when taken separately. The treatment is from Hims, and the user is satisfied with the progress, especially on the crown.

community 24F - AGA & TE since 14. Is this regrowth for sure?

in Is this regrowth? 2 upvotes 4 months ago

A 24-year-old woman with AGA and TE since age 14 is questioning if her hair is regrowing or breaking. She has been using minoxidil consistently since September 2025, along with caffeine and ketoconazole shampoos, rosemary oil, and saw palmetto, and has improved her overall hair care routine.

community Hair loss over a year following depression and taking antidepressants

in Side effects? 200 upvotes 4 months ago

A 33-year-old experienced significant hair loss after a depressive episode and taking paroxetine, possibly due to telogen effluvium or androgenic alopecia. Suggestions included reducing alcohol, considering finasteride and minoxidil, and consulting a doctor about antidepressant side effects.

community I cannot even tolerate Nutrafol

in Product 6 upvotes 6 months ago

The user experienced side effects from finasteride and Nutrafol, opting for non-hormonal treatments like minoxidil, exercise, and a healthy lifestyle. Others discussed using Dutasteride, Biotin, and minoxidil with varying success and side effects.

community 31M. Just diagnosed with androgenic alopecia. Fears of min.

in Finasteride/Dutasteride 12 upvotes 7 months ago

A 31-year-old man with androgenic alopecia is considering treatments like finasteride, minoxidil, and ketoconazole shampoo but is worried about finasteride's side effects. Users recommend starting with finasteride or dutasteride for DHT blocking, suggesting topical solutions to reduce side effects.

community There is simply no way to get finasteride in Germany

in Finasteride/Dutasteride 82 upvotes 1 year ago

A user in Germany struggles to get a finasteride prescription despite trying multiple doctors and apps, only receiving minoxidil. Other users suggest alternative sources like Zava.med, EU doctor App, and buying from pharmacies abroad.

community People who continue to lose hair on fin/dut, Are you on Nicotine?

in Research/Science 81 upvotes 10 months ago

Nicotine use, especially from vaping, may worsen hair shedding and reduce the effectiveness of finasteride and dutasteride. Quitting nicotine seems to improve hair health.

community When I’m 60 and finally off the fin after 40 years and look at my semen

in Satire 862 upvotes 4 years ago

Hair loss treatments discussed include Minoxidil, Finasteride, and RU58841. Users share experiences with Finasteride, mentioning watery semen as a side effect and weighing its importance against maintaining hair.

community Pyrludimide (KX-826) or Breezula (clascoterone)

in Treatment 9 upvotes 1 month ago

The conversation is about hair loss treatments, specifically Pyrludimide (KX-826) and Breezula (clascoterone), with the user unable to tolerate finasteride and dutasteride. The user plans to use these treatments alongside minoxidil, considering the efficacy and availability of each option.

community has anyone heard of Wellbutrin causing hairloss??

in Chat 2 upvotes 3 years ago

Wellbutrin may cause hair loss, as several users reported increased hair shedding while on the medication, with hair regrowth observed after stopping it. Minoxidil was used by one user to help with hair loss, and turmeric was noted to thicken hair.

community Hair Loss Associated with Escitalopram (anti-depressant). Do SSRIs Affect the Hair Follicle?

in Research/Science 7 upvotes 1 year ago

A 22-year-old male experienced hair loss potentially linked to escitalopram, which stopped after switching to vortioxetine. His depressive symptoms improved with continued treatment.

community EMA is re-examining Winlevi (clascoterone at lower concentration)

in Treatment 8 upvotes 10 months ago

Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.

community KX-826: My initial thoughts and observations on pyrilutamide...

in Treatment 1 upvotes 1 year ago

The user tried pyrilutamide for hair loss and noticed reduced scalp itch and improved skin but stopped due to mild heart sensations. They plan to update after consistent use, noting improved sleep when applied at night.

community No side effects on pyrilutamide / KX-826 so far

in Research/Science 208 upvotes 4 years ago

User TopBack56 and friends tried pyrilutamide (KX-826) for hair loss without experiencing negative side effects. They observed fine vellus hairs but no thick hair growth yet, and plan to add GT20029 to their regime after safety trials.

community When will Breezula be released and how does it compare to KX-826?

in Research/Science 2 upvotes 9 months ago

Breezula (clascoterone) is expected to be available by late 2026, showing good long-term results with minimal side effects. KX-826 (pyrilutamide) acts faster but is still in earlier development stages.

community 32M Considering Topical Xyon or RU58841 for ED from Oral Dutasteride

in General 118 upvotes 8 months ago

A 32-year-old male experienced erectile dysfunction and decreased libido after using oral dutasteride and minoxidil for hair loss. He is considering switching to topical alternatives like Xyon dutasteride or RU58841 to reduce side effects.

community 5mg KX 826 Worked. Will 2.5mg Hold?

in Technology 6 upvotes 1 year ago

Reducing the dose of Pyrilutamide from 5mg to 2.5mg may still maintain hair loss results, but effectiveness can vary. Users discuss the cost and dosage implications, with some cautioning against reducing the dose due to its dose-dependent nature.

community Don’t get too hyped up about Breezula, it‘s not a wonder drug

24 upvotes 7 years ago

The conversation discusses skepticism about Breezula, a hair loss treatment, with the consensus that it's not a miracle cure but a maintenance drug that may work well with finasteride. Some users report side effects from finasteride, like sexual dysfunction, while hoping for better results from Breezula or RU58841 without such side effects.

community Clascoterone/ Breezula will it work

in Research/Science 1 month ago

Breezula's effectiveness is uncertain, with some users skeptical about its potential and others noting its recent availability on the grey market. A user reported success with a stack of Dutasteride (oral), Minoxidil (topical), and RU58841 (topical), achieving significant hair improvement after 18 months.

community RU58841 once vs twice daily? Is once a day effective enough?

in Treatment 1 upvotes 1 month ago

RU58841 is effective when used once daily. Using it twice daily may require reducing the dosage, potentially decreasing its effectiveness.

community KX-826 1% Phase II Results from China Just Dropped

in Research/Science 35 upvotes 9 months ago

KX-826 (Pyrilutamide) 0.5% and 1.0% solutions showed promising results in increasing hair count for male androgenetic alopecia, with the 0.5% dose slightly outperforming the 1% dose. The treatment was well-tolerated with no sexual side effects, but skepticism remains due to past inconsistencies in trial results.

community Breezula 6 Month Topline Phase III Results Released

in Research/Science 173 upvotes 5 months ago

Breezula shows promising hair growth results, with up to 539% increase in hair count compared to placebo, and regulatory submissions are planned in the US and EU. Users are cautiously optimistic, noting the potential for Breezula to replace finasteride by targeting DHT without systemic effects.

community On the topic of HMI-115 and prolactin: has anyone tried adding Vitamin B6 (P-5-P) to their topical solutions?

in Research/Science 7 upvotes 2 years ago

The conversation discusses the potential benefits of adding Vitamin B6 (P-5-P) to topical hair loss treatments like RU58841, finasteride, or minoxidil. The user suggests that Vitamin B6 might enhance these treatments by naturally lowering scalp prolactin.

community Excited to stack Finasteride+Kx826 😃

in Research/Science 37 upvotes 1 year ago

The conversation is about using finasteride and KX826 for hair loss treatment. The original poster is using 0.25 mg of finasteride every other day due to side effects at a higher dose.

community Pyrilutamide / KX-826 | Discussion EU

in Research/Science 4 upvotes 2 years ago

The conversation is about a user expressing concerns over the safety of a new drug called Pyrilutamide (also known as KX-826) for hair loss. The user will only trust the drug if it's permitted by EU regulations and sold by a reputable company.

community Kintor KX -826 Pyrilutamide Adds 1 Year Phase 3 Trial For Safety

in Technology 54 upvotes 2 years ago

KX-826/pyrilutamide is undergoing an additional one-year safety and efficacy trial in China after a six-month study. Some participants speculate on the reasons for the extended trial and discuss the potential of other treatments.

community KX-826 Pyrilutamide1% coming soon

in Update 152 upvotes 1 year ago

KX-826 Pyrilutamide 1% is launching soon, and users are discussing its potential benefits and drawbacks compared to other treatments like Minoxidil and finasteride. Some users are skeptical about its effectiveness, while others are hopeful it will be a safer alternative.

community Joining clinical study for Clascoterone (Breezula)

in Research/Science 7 upvotes 1 year ago

The conversation is about a user considering joining a clinical study for Clascoterone (Breezula) after experiencing no results with topical finasteride and minoxidil, and side effects from oral finasteride. The user is seeking advice on clinical study participation and experiences.