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      community When is Breezula expected to be available for the public?

      in Question  28 upvotes 7 years ago
      The conversation is about the availability of Breezula, a hair loss treatment, with speculation it might be released in 2022 or potentially never, as it's more effective than finasteride. No specific treatments were confirmed.

      community Massaging scalp, day 163, Update. NEED ADVICE!!

      in Chat  2 upvotes 3 months ago
      The conversation discusses hair loss treatments, including scalp massage, and the importance of blocking DHT for hair loss management. The user shares blood test results, which appear normal, and seeks advice on effective tests and treatments, expressing a preference for natural methods over medication.

      community topical fluridil/eucapil + dut to block all DHT+T from scalp?

      in Treatment  8 upvotes 4 years ago
      User experienced slow gains with topical fin+min, switched to topical dut+min, and considered adding Eucapil. Another user suggested DUT may be less effective topically due to high molar mass and mentioned Fluridil as a weak anti-androgen that could help.

      community Black market pp405? Title title

      in Treatment  8 upvotes 4 months ago
      PP405 is likely fake, and JXL069 is an unrefined prototype with unknown side effects. It's advised to wait for the official PP405 release.

      community Can vitamin b7 deficiency cause receded temples?

      in Treatment  3 upvotes 5 years ago
      A user was frustrated with delays in getting finasteride for hair loss, was prescribed minoxidil, and found a vitamin B7 deficiency. They are questioning if the deficiency could cause receded temples and considering finding a new dermatologist.

      community Reasonable and safe stack? Bloodwork within.

      in Minoxidil  1 upvotes 2 years ago
      A 26-year-old male is using a combination of clomiphene, minoxidil, tadalafil, bupropion, and lisdexamfetamine to address low testosterone, ED, depression, and focus issues. He seeks input on the safety and efficacy of this regimen, which also includes magnesium, zinc, and fish oil supplements.

      community Expectations control for SCUBE3

      in Research/Science  22 upvotes 2 years ago
      SCUBE3, a protein linked to hair growth in moles, was discovered over 25 years ago and is being developed by Amplifica for potential hair loss treatment. Concerns exist about SCUBE3's association with cancer, as it is a protein that promotes cell growth, which could potentially trigger cancer development if used for hair growth therapy.

      community ABS-201 Trial - What should I know going in

      in Research/Science  28 upvotes 3 months ago
      The conversation is about a user preparing to join the ABS-201 clinical trial for hair loss treatment, which involves a prolactin inhibitor. The user plans to update others on their progress if enrolled.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community A rare case? Or a blind spot? Hair loss caused by low T + e2

      in Chat  10 upvotes 1 year ago
      Low testosterone and estradiol may contribute to hair loss, and blocking DHT without sufficient hormone levels might hinder regrowth. The discussion highlights the importance of hormone balance, with some considering supplements and lifestyle changes to support hair health.

      community Evidence-based natural treatment that works for me

      in Treatment 2 years ago
      A user shared a natural hair loss treatment involving micro-needling and a mix of turmeric, cinnamon, and coconut oil, claiming it effectively thickened their hair. The treatment is applied every two to three weeks, but some users expressed skepticism and requested photographic evidence.

      community Where is GT20029 already? Grrrr

      in Research/Science  20 upvotes 2 years ago
      The conversation is about frustration over the delay in phase 2 results for a hair loss treatment called GT20029. One user suspects the treatment may have failed.

      community Anyone here actually do topical cetirizine?

      in Question  4 upvotes 8 years ago
      The conversation discusses using topical cetirizine for hair loss and questions its effectiveness and preparation. A user expresses interest in trying it if it can be dissolved in minoxidil.

      community Haunting study is making me considering cycling fin/dut

      in Research/Science  158 upvotes 10 months ago
      Concerns about the long-term effects of dutasteride and finasteride on fertility, with discussions on cycling these medications to mitigate risks. The conversation highlights skepticism about study methodologies and the importance of weighing treatment risks against potential fertility issues.

      community What ever happened to pyrilutamide?

      in Technology  48 upvotes 3 years ago
      Pyrilutamide, a potentially effective hair loss treatment; other topical treatments like RU58841 and CB-03-01 that may have fewer side effects than Pyrilutamide; and the Phase 3 clinical trials of Pyrilutamide, which is likely to be approved by the FDA soon.

      community Pp405 phase 2a clinical results

      in Research/Science  40 upvotes 11 months ago
      PP405 shows initial promise for treating androgenetic alopecia, with safety confirmed in early trials, but skepticism remains due to limited data. Further trials are needed to determine its true efficacy and potential market impact.