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      community Just a rule of thumb regarding "the cure™"

      in Chat  8 upvotes 2 months ago
      Be skeptical of claims about new baldness cures; current treatments like finasteride, dutasteride, and minoxidil remain the best options. New products like Breezula and PP405 lack compelling evidence and may not be available soon.

      community The mechanism of androgenic alopecia

      in Research/Science  33 upvotes 6 months ago
      DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

      community Does caffeine inhibit 5-α-reductase?

      in Treatment  4 upvotes 6 years ago
      Caffeine may promote hair growth and potentially inhibit 5-α-reductase activity in hair follicles, but its effectiveness and systemic impact remain unclear. Users discuss using topical caffeine solutions, with some experiencing no side effects compared to finasteride.

      community 10 weeks on 0.25mg fin daily + collagen + biotin supps

      in Progress Pictures  29 upvotes 1 year ago
      User experienced hair regrowth and no side effects after 10 weeks on 0.25mg finasteride daily, along with biotin, collagen, micro-needling, and hair oil. They stopped minoxidil due to inconvenience and noticed initial shedding but now see more fullness.

      community CB-03-01 users come forward!

       13 upvotes 6 years ago
      The conversation discusses the potential of a new hair loss drug, CB-03-01, with users sharing their experiences and seeking advice on dosages and application methods. One user mentions using topical finasteride, minoxidil, dermarolling, and a clean diet for hair maintenance but is interested in CB-03-01 due to side effects from finasteride.

      community Is PP405 gonna flop or what???

      in Research/Science 1 week ago
      PP405 is viewed skeptically, with some seeing it as overhyped and potentially ineffective compared to existing treatments like minoxidil and finasteride. While it shows some promise in activating dormant hair follicles, many believe it won't replace hair transplants or significantly outperform current options.

      community How likely do you think it is for PP405 to come out?

      in Research/Science  21 upvotes 6 months ago
      PP405 is a potential new hair loss treatment that works through metabolic pathways rather than hormonal ones, with an estimated market release between late 2027 and 2029. Current alternatives to finasteride include minoxidil, pyralutamide, fluridil, and RU58841, with hair transplants also being a viable option.

      community DNA test result is incredible !

      in Technology  31 upvotes 2 months ago
      The conversation discusses a personalized hair loss treatment plan based on DNA test results, recommending Minoxidil, Dutasteride, 17-alpha Estradiol, Cetirizine, and PRP sessions. The test identifies a high risk of hair loss due to DHT but a good response to Minoxidil, suggesting a tailored approach to treatment.

      community Ketoconazole shampoo for early-stage shedding looks like working!

      in Ketoconazole  33 upvotes 8 months ago
      Ketoconazole shampoo may help with early-stage hair loss by stopping hair regression and promoting new hair growth, though its effectiveness as a DHT blocker is debated. Users report varying results, with some experiencing dryness and others seeing improvement when used 2-3 times a week.

      community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

      in Research/Science  134 upvotes 1 year ago
      The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

      community is there any news about pp405 please

      in Update  11 upvotes 1 year ago
      There is no new information on pp405, with data collection expected to finish by the end of 2025. Users are discussing the timeline for data analysis and completion of Pelage Pharmaceuticals' phase 2 study.

      community M22 Shedding recovery fin 1mg min 1ml

      in Finasteride/Dutasteride  142 upvotes 2 years ago
      A user shared their experience with hair loss treatment using finasteride (1mg) and minoxidil (1ml), noting significant shedding phases but hoping for improvement. Shedding is a common synchronized effect of the treatment, which may desynchronize over time, potentially taking over 5 years.

      community 5 Month Update - Fin, minoxidil, ru58841, dermapen 1.7mm

      in Progress Pictures  91 upvotes 4 years ago
      The conversation discusses a 5-month hair loss treatment regimen including finasteride, minoxidil, RU58841, dermapen (1.7mm), and ketoconazole shampoo, with noticeable hair regrowth. One user notes the hair appears thicker, while another mentions RU58841 is not doctor-recommended.

      community Track hairline of Pelage executives

      in Research/Science  39 upvotes 5 months ago
      Pelage executives' hairlines were discussed, with speculation about them using PP405 for hair regrowth. Concerns were raised about using untested drugs, with some suggesting executives might not risk using them without safety data.

      community Entering Month 5 of topical fin/min

      in Progress Pictures  16 upvotes 1 year ago
      A 28-year-old male is happy with his hair regrowth on the crown after using topical Minoxidil 5% and Finasteride 0.25% once daily, micro needling weekly, and Nizoral shampoo once a week. He has experienced no significant side effects, and his hair has become darker and thicker, with improvements in his hairline.
      There is hope guys, M28 75 days of Fin&Min

      community There is hope guys, M28 75 days of Fin&Min

      in Journals / Progress Pictures  91 upvotes 4 months ago
      A user shared progress pictures showing improved hair fullness after 75 days using 2.5mg oral minoxidil daily, 1mg oral finasteride every other day, a 1.5mm dermastamp weekly, and daily scalp massages. They report seeing early positive results.

      community GT20029 Phase 2 results are out

      in Treatment  60 upvotes 4 months ago
      GT20029 shows promising results for hair loss treatment, with potential approval in China by 2026 or 2027, but U.S. approval may take longer. It could serve as an alternative to finasteride, with a potentially better side effect profile.