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Kintor Pharmaceutical's Phase 2 results with the drug Pyrilutamide, a potential alternative to 5-ARI drugs like Finasteride and Dutasteride but without the side effects. It could be used in combination with other topical treatments such as Minoxidil. The safety of the drug has been demonstrated in 6 months of use, however there are still questions about long term efficacy and systemic absorption.

User has itching, dandruff, and scalp issues, considering Nizoral 1% shampoo for treatment. Nizoral's effectiveness for hair loss is uncertain due to limited research, short contact time, and concentration differences.

Using a topical formula with 5% minoxidil and 0.01% retinoic acid is considered effective, as tretinoin can enhance minoxidil results and improve scalp health.

Breezula results are awaited, but no updates have been posted. Users are uncertain about its promise.

The conversation discusses combining topical cetirizine with minoxidil for hair loss treatment and inquires about the safety and absorption through the skin, as well as the possibility of adding melatonin.

The user plans to use 1% Koshine826, 0.1% Alfatradiol, Minoxidil with Tretinoin, microneedling, and Stemoxydine for hair loss treatment. They expect significant recovery with this regimen.

Ketoconazole shampoo does not significantly reduce systemic or scalp DHT levels and is mainly used for its anti-fungal and anti-inflammatory effects. It is not a replacement for finasteride, which is recommended by some users despite concerns about side effects.

A user confirmed that koshinemall.com is the official site for buying Pyrilutamide after contacting Kintor directly. They expressed initial skepticism due to the website's quality and phone number requirement.

User experienced dandruff after starting Nizoral and switching to a lemon-scented shampoo. They stopped using Nizoral and plan to switch back to unscented shampoo to resolve the issue.

The conversation discusses the application frequency of a 1% Koshine solution for hair loss, with recommendations varying between once or twice daily. It is noted that the 1% solution is more effective than the 0.5% solution.

An 18-year-old experienced severe side effects, including heart palpitations and high blood pressure, after using RU58841 once, leading to a referral to cardiology for suspected left ventricular hypertrophy. The user regrets using RU58841 and seeks advice on recovery, while others suggest preexisting conditions or genetic predispositions may be factors.

The conversation discusses whether to get a blood test to check DHT levels while using Dutasteride for hair loss and concerns about Quercetin's potential interaction with Dutasteride. It concludes that testing DHT isn't necessary unless no effects are seen, and the small amount of Quercetin in a multivitamin likely doesn't interfere with treatment.

The user is concerned about hair loss despite taking finasteride and has a hair transplant scheduled. They experience scalp itching and burning, which hasn't been relieved by various treatments, and another user suggests using ghk-cu & ahk-cu serum and Koshine kx-826/pyrilutamide for relief.

Breezula® (Clascoterone) showed promising results in a Phase 2 trial for treating hair loss, being as effective as Propecia with no serious side effects. It might be released between 2021-2022, and a related acne treatment with the same active ingredient could be used in the meantime.

Managing seborrheic dermatitis using ketoconazole shampoo, Nizoral, and oils like MCT and coconut oil. The user considers shaving their head and consulting a dermatologist.

OP has been using a premixed topical solution of 5% minoxidil and 0.025% tretinoin for 6 months with good results and is unsure if shaking the bottle is necessary. OP is also using Dutasteride and is curious about the impact of shaking on treatment effectiveness.

A 35-year-old shared their 5-month hair regrowth progress, using 0.5mg oral finasteride daily, topical minoxidil/finasteride once daily, derma stamping 1-3 times a week, washing hair daily or every other day with peppermint soap, and using eczema lotion for scalp health. Commenters congratulated the individual on the significant improvement in their hairline.

OP mixed RU58841 with minoxidil and noticed undissolved particles. They are seeking advice on whether it matters or how to fully dissolve it.

A user noticed watery semen and decreased volume after a week of using finasteride and asked if taking Zinc, pygeum, and lecithin supplements would affect finasteride's effectiveness. The conversation is about the side effects of finasteride and potential supplements to counteract them.

The user experienced genital itching while using finasteride and noticed a yellow bump, which improved with clotrimazole, but the itching persists. The discussion focuses on side effects of finasteride.

Hair loss discussion includes treatments like hinoki tree oil and procyanidin b2. Experiences and effectiveness of these treatments are shared.

The conversation is about hair loss treatment using finasteride, ketoconazole, and sulfur soap, with consideration of starting dermastamp. The user prefers not to use minoxidil.

The conversation discusses adjusting the isopropyl alcohol, propylene glycol, and water ratios in a topical finasteride solution for better scalp comfort and less dandruff. The user considers using 20ml IPA, 25ml PG, and 15ml water in a 60ml bottle, moving away from mixing finasteride with topical minoxidil.

The user is looking for a PG-free solvent in the UK or EU to make their own pyrilutamide solution for hair loss and is currently using finasteride, considering minoxidil. They hope pyrilutamide will help stabilize their hair loss.

Selling KY19382 powder, a novel activator of Wnt/β-catenin signaling, and Kolliphor EL liquid for vehicle formulation. KY19382 is a growth agonist.

The user is switching from oral to DIY topical finasteride due to side effects and is using a solution with 10 mg finasteride in a 100 mL mixture. They are concerned about the effectiveness of the formula due to white sediment forming in the solution.

The conversation is about a user considering reducing their dutasteride dose due to side effects like lower libido and watery semen. They plan to use dutasteride mesotherapy every three months to maintain hair while reducing systemic DHT suppression.

Discussing a regimen to improve the user's hairline, with treatments proposed including minoxidil, rectal microneedling, IV drip of minoxidil, laser removal, PRP injection, topical minoxidil, divine protein shakes, stem cell injections, and keto shampoo.

Clascoterone, a topical anti-androgen for hair loss, is expected to be released in late 2026 or early 2027.

A user in Russia is trying to make topical finasteride at home using ethanol, finasteride tablets, water, and propylene glycol due to unavailability in their country. They are concerned about tablet residue and considering using isopropyl alcohol or adding finasteride to a hair growth lotion.