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      community Ru with gloves because of Systemic absorption?

      in Research/Science  10 upvotes 2 years ago
      The conversation is about whether to use gloves when applying 5% RU58841 to avoid systemic absorption and if washing hands with water is sufficient. Users question the concern, noting it is applied to the scalp.

      community Why was fluridil abandoned and never made past phase 2?

      in Chat  4 upvotes 4 years ago
      Fluridil was abandoned due to its weak effectiveness and low binding affinity to the androgen receptor, making it less competitive against DHT and testosterone. Users discuss its limited results compared to other treatments like pyrilutamide and RU58841.

      community Anyone here actually do topical cetirizine?

      in Question  4 upvotes 8 years ago
      The conversation discusses using topical cetirizine for hair loss and questions its effectiveness and preparation. A user expresses interest in trying it if it can be dissolved in minoxidil.

      community RU58841 carrier - PG/Ethanol vs KB solution?

      in Treatment  2 upvotes 4 years ago
      The conversation discusses the differences between PG/Ethanol and KB solutions for RU58841 application, focusing on potential scalp irritation. KB solution is suggested for those allergic to PG, though both contain ethanol which can dry the scalp.

      community Topical Minoxidil /Fin with tretinoin

      in Minoxidil  1 upvotes 2 years ago
      A dermatologist prescribed a topical solution with 7% minoxidil, 0.1% finasteride, and 0.015% tretinoin from Medrock pharmacy. The user is asking if anyone has tried it and if it contains alcohol.

      community How to mix ru58841 powder into minox??

      in Treatment  2 upvotes 1 year ago
      Mixing RU58841 powder into minoxidil can result in undissolved particles. Shaking the bottle and breaking up the grains may help dissolve it better.

      community RU-58441 Janoshik test result of Made-In-China Supplier

      in Product  27 upvotes 6 months ago
      A user ordered RU58841 from a Chinese supplier, found it to be less than 99% pure, and plans to try a different seller next time. Concerns were raised about impurities, but the user believes they are likely inactive fillers rather than harmful substances.

      community What makes breezula different than formula 82f?

      in Question  9 upvotes 6 years ago
      Breezula (clascoterone) and Formula 82F (topical finasteride) are treatments for hair loss that block DHT differently; Breezula competes with DHT at the hormone receptor site without systemic effects, while 82F inhibits the enzyme that converts testosterone to DHT. Breezula may work for those who don't respond to finasteride and vice versa.

      community Does anyone know the chemical formula for pelage pp405?

      in Research/Science  14 upvotes 1 year ago
      The conversation discusses the lack of public information on the chemical structure of PP405, a hair loss treatment, and the challenges of synthesizing it without a patent. It also explores a patent related to hydrogen-based topical formulations for reducing oxidative stress and inflammation.

      community Cosmo Pharma Lists Breezula Phase 3 Trial on ClinicalTrials.gov

      in Research/Science  26 upvotes 2 years ago
      A phase 3 trial for Breezula (clascoterone solution) to treat male pattern hair loss has been listed, with 726 participants and a completion date of January 2025. Other treatments mentioned include Aneira Pharma's combination of minoxidil and latanoprost, Triple Hair's combination of minoxidil, latanoprost, and finasteride, and a new microneedling and LLLT device called StimuSIL.

      community The future of hair loss drugs.

      in Research/Science  31 upvotes 3 months ago
      Clascoterone 5% and PP405 are being discussed as potential future treatments for hair loss, with clascoterone nearing phase three completion and PP405 possibly taking a cosmetic route to market. Current treatments like minoxidil, finasteride, and RU58841 are mentioned as effective in slowing hair loss, but a complete cure remains elusive.

      community EMA is re-examining Winlevi (clascoterone at lower concentration)

      in Treatment  8 upvotes 11 months ago
      Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.

      community Taking part in a Clascoterone Study

      in Treatment  6 upvotes 2 years ago
      The conversation is about a person considering participating in a study for Clascoterone, a topical cream for hair loss, and seeking advice on potential side effects. They have mild hair loss and are not currently using other treatments like finasteride.

      community Why nobody uses 0.25% (2.5mg/ml)?

      in Treatment  66 upvotes 2 years ago
      The conversation is about the effectiveness of 0.25% topical finasteride compared to other concentrations and forms. Users discuss its potential for better scalp DHT reduction and fewer side effects, with some preferring topical over oral treatments.

      community How do you check the purity of Ru or Breezula

      in Product  7 upvotes 4 years ago
      The conversation is about someone wanting to import RU58841 or CB-03-01 from China for hair loss treatment but being concerned about receiving counterfeit products. Specific treatments mentioned are RU58841 and CB-03-01.

      community shampoo with piroctone olamine in US?

      in Product  1 upvotes 5 months ago
      The conversation is about finding a reasonably priced shampoo with piroctone olamine in the US. The user is cautious about trying new or smaller brands.

      community M25 - Need Non alcoholic minoxidil options available in India

      in Product  1 upvotes 1 month ago
      The conversation is about finding non-alcoholic minoxidil options in India due to irritation from propylene glycol-based formulations. Suggestions include Tugain 5% foam, Morr Max 5%, minoxidil gel, and Morr F Aqua plus, with OP avoiding finasteride due to side effects.