community PP405 will be available on Everychem soon apparently
PP405 is a potential hair loss treatment, but its safety and effectiveness are uncertain. Users advise caution and suggest waiting for more data before purchasing unverified versions.
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510-540 / 1000+ resultscommunity Female AGA - Low Cortisol/Low DHEA
Female (37) experiencing hair loss for 5 years, tried max dose of spiro and oral + topical minox without success. Discovered low cortisol and low DHEA levels, seeking functional medicine practitioner for help.
community 0.25 alfatradiol or 0.5 Pyrulitamide ?
The conversation is about choosing an anti-androgen for hair loss treatment, with options being alfatradiol and pyrilutamide. Alfatradiol is considered a better choice due to its established use, while pyrilutamide is more experimental.
community UCLA scientists found a molecule — PP405 — that wakes up sleeping hair follicles and tells them, “Do your job.”
PP405 is a promising molecule that may reactivate dormant hair follicles, potentially offering a new treatment for hair loss. It is in phase 2 trials, with possible availability between 2027 and 2030.
community I got my blood test results, my Thyroid and Ferritin are good but Vitamin D is 11.1 I started topic minoxidil yesterday (5%)
The user has androgenetic alopecia (AGA) and low Vitamin D levels, and they started using topical minoxidil (5%). They are considering finasteride but are concerned about side effects and are advised to seek mental health support.
community I have heard that Amplifica - Scube3 initiate a human study for AGA, but I cannot find any information about it from clinictrial.gov. Amplifica did not state it is a phase 1 clinic trial or not, it says it is "The initiation of our first-in-human clinical study"
The conversation is about a user seeking information on a clinical trial by Amplifica - Scube3 for Androgenetic Alopecia (AGA). The user is unsure if it's a formal phase 1 study.
community Clascoterone 5% Delivers Strong Phase 3 Hair-Growth Results
Clascoterone 5% solution shows strong potential for hair growth, offering a new treatment for alopecia with minimal side effects. It blocks androgen receptors locally and may be available by late 2026 or early 2027.
community Getting PP405. Now…. or as soon as possible
People are discussing obtaining and testing PP405 for hair loss treatment, with concerns about its purity and effectiveness. Some are considering delaying hair transplants, while others suggest using existing treatments like finasteride and minoxidil.
community DNA Testing by Roots by Genetic Arts
A user shared their positive experience with Roots by GA, a company that creates personalized hair loss treatments based on DNA analysis, which confirmed their inability to tolerate finasteride. The user is satisfied with their progress 30 days after a hair transplant and the customized formula they received.
community Before & After - 5 months on 0.5mg
The user experienced significant hair regrowth after 5 months on 0.5mg of finasteride, with no side effects except mild, temporary testicular pain. Minoxidil was used for 5 years without noticeable results, and dermastamping and rosemary oil were also mentioned as part of other users' routines.
community Dim: high estradiol levels what to do
A user is experiencing facial bloating from low-dose topical finasteride due to high estradiol levels and is seeking advice on using DIM to manage this issue, including dosage and brand recommendations.
community 5 months topical minoxidil and 1 mg oral fin, identical hair lengths.
A 25-year-old shared impressive hair regrowth results after 5 months using 5% topical minoxidil (Rogaine and Kirkland) and 1 mg oral finasteride (Propecia), with no shedding or side effects. The user applies minoxidil twice daily and finasteride once daily.
community I've had 3 transplants, NW5a, and this is what I've learned
The post and conversation are about hair transplant tips and experiences. The user emphasizes thorough planning, essential packing, and post-surgery care, and regrets not using finasteride earlier.
community Future hope ? What do you guys predict ? clascoterone, pyrilutamide, gt20029 etc.
User tried oral finasteride, topical finasteride, topical dutasteride, and RU58841 but experienced side effects. They discuss upcoming treatments like clascoterone, pyrilutamide, gt20029, and KY19382 as potential options.
community Finasteride gains continue well into year 5
Finasteride can continue to improve hair loss for up to 10 years, with the best results seen when started early. Combining treatments like minoxidil, dermarolling, or RU58841 may enhance effectiveness.
community norwood 7 from both sides of family, destined to go bald 17M
17M approaching Norwood 2, using topical minoxidil and considering finasteride, oral minoxidil, and pyrilutamide. Plans to study dermatology and possibly get a hair transplant at 25 if treatments don't work.
community 5 months 5% minoxidil twice a day 1mg finasteride per day
A user shared impressive hair regrowth results after using 5% topical minoxidil twice daily and 1mg oral finasteride daily for five months. The user reported no side effects and did not use additional treatments like PRP or dermarolling.
community Kintor has released an investor relations memo regarding Chinese Phase III trials for Pyrilutamide
Kintor's Pyrilutamide (KX-826) showed hair growth in Chinese Phase III trials but did not significantly outperform placebo. The treatment was safe with no major adverse reactions reported.
community Saved hairline. 2.5 year transformation. 2.5 years of 0.5mg finasteride + RU (1.5g spread over 2.5 years)
A user's 2.5 year transformation of using 0.5mg finasteride and RU58841 to combat hair loss, with the possibility of increasing the RU for further regrowth.
community PP405 vs Hair Cloning – Which Would Be Better for NW7 to NW1?
PP405 and hair cloning are discussed as potential treatments for reversing hair loss from Norwood 7 to Norwood 1. Hair cloning is seen as a more permanent solution, while PP405's effectiveness and long-term effects remain uncertain.
community Extreme shedding after ~1 year on 5% topical minoxidil — normal or problem?
A 17-year-old using 5% topical minoxidil experienced significant hair shedding after a year, possibly due to a "synchronization shed" and deficiencies in vitamin D and iron. Recommendations include continuing minoxidil, optimizing vitamin D and iron levels, and reducing tretinoin use if scalp irritation occurs.
community hmi115 is coming. Prepare yourselves for what's coming
The conversation discusses HMI-115, a potential cure for hair loss. Users share mixed opinions, with some expressing skepticism and others sharing anecdotal evidence of its effectiveness, including photos of significant hair regrowth from a trial participant.
community Just FYI, Here are pictures of 6 months results on Clascoterone 5%. Is it remarkable? No. But it seems likely to be FDA approved considering 1% is already available. This is a win, especially if you pair it with other treatments like Finasteride.
Clascoterone 5% shows potential for hair thickening and darkening, especially when combined with treatments like finasteride. It may be a good alternative for those who experience side effects from other treatments.
community Amplifica and AMP-303 clinical phase 1
Amplifica is testing a compound called AMP-303 for hair loss, but it's not Scube3 or osteopontin. The timing for the results from the clinical trial is unknown.
community I have Post PP405 Syndrome(PPS). Should I start a foundation?
The conversation humorously discusses the fictional "Post PP405 Syndrome" and the idea of starting a foundation or cult around it. It mentions skepticism about the effectiveness of PP405 and jokes about future therapies.
community Genetic testing to determine individualized hairloss treatment?
A user discusses a company, Roots by Genetic Arts, that offers a genetic test for hair loss to create personalized treatments, and is curious about its legitimacy and the science behind it. The company tests 16 genes related to hair loss and compounds a topical treatment based on the results.
community Is this progress? 5 months on oral fin/topical min
The conversation is about someone's hair regrowth progress after 5 months of using oral finasteride and topical minoxidil. Specific treatments mentioned are oral finasteride and topical minoxidil.
community Are there any active Group Buys (dischord or other forums) for HMI 115?
Hair loss discussion includes treatments Minoxidil, Finasteride, and RU58841. HMI 115 shows anecdotal success in Phase I trial, users seek group buy for research chemical.
community 5 months Minoxidil+Fin progress
The conversation is about a user's 5-month progress using topical Minoxidil (5%) and Finasteride (0.1%) twice daily, along with derma stamping, improved Vitamin D levels, and increased protein intake for hair regrowth. The user is considering dutasteride if progress plateaus and uses a sulfate and paraben-free shampoo.
community 2.5 months of treatment
The user has been using 0.5 mg oral finasteride and recently switched to 2.5 mg oral minoxidil from topical application. They are observing potential early regrowth with longer baby hairs.