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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Dutasteride results after 1 year and a few months

      in Progress Pictures  111 upvotes 6 months ago
      Switching from finasteride to dutasteride led to significant hair regrowth and thickening for the user, who also uses ketoconazole shampoo. The user experienced increased libido and encourages others not to be discouraged by negative opinions about dutasteride.

      community 2.5mg minoxidil and 1mg finasteride 1caps daily

      in Chat  1 upvotes 1 year ago
      The conversation discusses using 2.5mg minoxidil and 1mg finasteride capsules daily for hair loss, with the addition of Nizoral shampoo for dandruff. It suggests switching to Selsun Blue if Nizoral worsens the condition.

      community Dutasteride 0.5 mg - Oral Minoxidil 2.5 mg / First month

      in Progress Pictures  9 upvotes 2 years ago
      A 24-year-old male with androgenetic alopecia is using a treatment of Dutasteride 0.5 mg, oral Minoxidil 2.5 mg, L-cysteine, and a Ketoconazole/Caffeine/CBD shampoo. He's considering using a dermaroller to improve results, taking biotin and iron vitamins, and quitting nicotine due to its potential link to hair loss.

      community Why take Dut only once a week?

      in Finasteride/Dutasteride  28 upvotes 5 months ago
      The conversation discusses using dutasteride once a week to boost finasteride's effectiveness in treating hair loss, with some users reporting fewer side effects and cost savings. Others share experiences with different dosages and combinations, including minoxidil and topical treatments, to find a balance between effectiveness and side effects.

      community Finasteride sleep related advice

      in Finasteride/Dutasteride  9 upvotes 1 month ago
      Finasteride can cause sleep disturbances, but these often improve over time. Some users experience side effects like reduced libido and brain fog, while others see hair regrowth and manage side effects by adjusting dosage or switching to topical treatments.

      community Dim: high estradiol levels what to do

      in Chat  8 upvotes 1 year ago
      A user is experiencing facial bloating from low-dose topical finasteride due to high estradiol levels and is seeking advice on using DIM to manage this issue, including dosage and brand recommendations.

      community When you pop your first Fin pill

      in Satire 5 years ago
      Hair loss treatment using Fin, Minoxidil and RU58841 with discussion about potential side effects and the power of nocebo effect.

      community 3 months on 1MG Finasteride Only

      in Is this regrowth?  462 upvotes 1 year ago
      The user experienced hair regrowth after 3 months of using 1mg finasteride daily, without any side effects. They avoided minoxidil due to dizziness and shared that finasteride is easily obtainable through a doctor or online services.

      community Been taking oral Finasteride for about 20 days now / update

      in Update  5 upvotes 1 year ago
      A 24-year-old male started taking oral Finasteride 1mg, biotin, and using Nizoral shampoo twice a week for hair loss prevention, reporting no noticeable side effects after nearly three weeks. He notes his hair looks better compared to a month ago.

      community Bicalutamide vs Finasteride for female AGA plus TE

      in Female  3 upvotes 1 month ago
      OP is considering Bicalutamide for female AGA and TE but is concerned about its side effects and effectiveness compared to Finasteride. OP is also using Minoxidil and Spironolactone but is experiencing significant shedding and is unsure if it's androgen-driven or due to Minoxidil changes.

      community Finasteride is saving me!!! 1 yr results

      in Progress Pictures  55 upvotes 8 months ago
      A 25-year-old male experienced significant hair regrowth after one year of using 0.5mg daily finasteride, with plans to add 1.25mg oral minoxidil and microneedling for further improvement. He also uses Nizoral shampoo weekly and reports no current side effects.

      community Dutasteride is amazing even for women with FAGA!

      in Female  151 upvotes 7 months ago
      Dutasteride significantly improved hair health and reduced shedding for a woman with PCOS and hyperandrogenism, without causing depression or anxiety, unlike finasteride. Dutasteride also helped with PMDD symptoms and had no side effects, though it changed hair texture.

      community Dutasteride .5mg Results Timeline

      in Finasteride/Dutasteride  14 upvotes 2 years ago
      A 21-year-old male switched from finasteride to 0.5mg dutasteride daily due to ongoing hair loss but has not seen improvement after 14 months, experiencing further thinning and recession. He is seeking feedback from other dutasteride users on their results after a similar duration.

      community 3 months of only Finasteride (1mg daily)

      in Progress Pictures  21 upvotes 1 year ago
      A 28-year-old male has been taking 1mg finasteride daily since January 26, 2024, with noticeable hair regrowth and no side effects. He also takes Vitamin D3 and a multivitamin daily and advises others to try finasteride despite potential side effects.

      community Change in Consumption of multivitamins

      in Treatment  2 upvotes 1 year ago
      The user discusses switching from multiple vitamins to a single multivitamin pill. They also mention using oral finasteride and topical minoxidil with finasteride for hair loss treatment.

      community Finnasterid (1mg) 5 month results

      in Progress Pictures  429 upvotes 9 months ago
      The user shared positive results after 5 months of using oral finasteride, reporting no side effects and continued shedding but less than in the initial months. Other users discussed their experiences with finasteride and minoxidil, with some expressing concerns about side effects and others sharing their own progress and plans.

      community The Ultimate Stack without finasteride

      in Treatment  15 upvotes 1 year ago
      A user successfully maintained hair using fluridil, alfatrodial, minoxidil, and ketoconazole shampoo after experiencing side effects from finasteride. They question why this combination isn't more popular despite its effectiveness.

      community Dutasteride 1mg or RU58841 8% or topical Dutasteride

      in Treatment  3 upvotes 10 months ago
      The discussion focuses on hair loss treatments, with suggestions to increase oral Dutasteride to 1 mg or more, as topical Dutasteride is less effective. Other treatments mentioned include RU58841, Minoxidil, and dermastamping, with some users recommending injectable mesotherapy and topical Finasteride.

      community I've finally found the cure

      in Satire  204 upvotes 5 years ago
      A regimen for hair loss, which includes using Nizoral shampoo twice daily, Minoxidil foam from the can, 5mg of Propecia crushed and snorted on weekends, and dermastamping directly to the head of the penis. Replies discuss potential sides and other treatments, as well as the idea that confidence is more attractive than hair.

      community Where to get Tretinoin? UK delivery

      in Treatment  3 upvotes 7 months ago
      The conversation is about finding affordable tretinoin with UK delivery options. Users discuss a finasteride, minoxidil, and tretinoin spray from e-surgery and suggest other sources like Zing meds and Skinorac.