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GlossaryCombability

ease of combing hair without resistance or damage

Combability refers to how easily hair can be combed or brushed without encountering resistance or causing damage. It is influenced by factors such as hair texture, moisture content, and the presence of tangles or knots. For professionals, assessing combability is crucial for determining the effectiveness of hair care products and treatments aimed at improving hair manageability and health.

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community Binding affinity does not equal potency for anti androgens? Comparing pyrilutimide to cb-03-01

in Research/Science 7 upvotes 3 years ago

Pyrilutimide and CB-03-01, two treatments for hair loss, have similar clinical trial results despite different binding affinities to androgen receptors. Factors other than binding affinity, like the time a drug stays bound to the receptor, may influence their effectiveness.

community Dermatch as good or better than Hair Fibres?

in Product 6 upvotes 3 years ago

Dermmatch is wind and water proof, but requires more hair to look good. Using both Dermmatch and hair fibers together can provide better coverage and a more natural look.

community Combining topicals together or use them separately

in Chat 4 upvotes 9 months ago

Combining Minoxidil with Finasteride or RU58841 may cause interference, irritation, or reduced absorption. It might be better to apply one topical at a time and wait an hour before applying another.

community Combining all your topicals into one

in Treatment 3 upvotes 2 years ago

The user is using a hair loss treatment regimen that includes applying various topical solutions and taking oral medication. They are mixing their topical treatments to save time but are concerned about the effectiveness of the treatments when combined and stored.

community Binding affinity of pyrilutamide!

in Update 168 upvotes 4 years ago

Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

community Combine minoxidil, tazarotene, lumigan

in Treatment 3 upvotes 10 months ago

Combining minoxidil 5%, tazarotene 0.1% cream, and lumigan for hair loss treatment is discussed. The conversation focuses on the safety and effectiveness of using these treatments together.

community Can you mix different topicals into 1 solution?

in Chat 2 upvotes 1 year ago

Combining minoxidil, pyrilutamide, and copper peptide is questioned, with advice to apply them separately to avoid reactions. Finasteride and minoxidil are recommended for effectiveness.

community An arthritis drug that can be used for Alopecia.

in Research/Science 5 upvotes 4 years ago

An arthritis drug, baricitinib, is discussed as a potential treatment for autoimmune alopecia, not androgenetic alopecia. Ritlecitinib is also mentioned as a possible treatment for scarring alopecia.

community Pyrilutamide binding affinity is similar to RU

in Research/Science 16 upvotes 3 years ago

Comparing the effectiveness of RU58841, Pyrilutamide and CB-03-01 as treatments for hair loss, with people discussing different aspects such as binding affinity, time of inhibition, safety data and cost.

community A theory about "embracing" the bald look

in Chat 173 upvotes 6 months ago

Baldness and modern fashion trends, with a focus on shaving heads and using treatments like minoxidil to manage hair loss and enhance appearance.

community Compunded Oral Minoxidil, As Efficient As Tablet Variants?

in Minoxidil 146 upvotes 7 months ago

The user discusses using compounded oral minoxidil due to the ineffectiveness and inconvenience of topical minoxidil for diffuse thinning. They question the efficacy of compounded minoxidil compared to original tablet forms and express concerns about the importance of excipients and binders.

community Experience with CB (Breezula)?

in Research/Science 4 upvotes 6 years ago

CB 03 01 (Breezula) was tried for hair loss but showed no significant improvement, with issues in dissolving and application. Finasteride and dutasteride remain the most effective treatments, while minoxidil is also used; CB's effectiveness is questioned, and topical alternatives like bicalutamide are considered.

community common ideas amongst bald communities that doesnt help at all in my opinion

in Chat 24 upvotes 2 months ago

Balding is challenging, and relying on medications like finasteride is often seen as a better option than constantly shaving or trying to compensate in other areas. Many feel that societal expectations to "own it" or drastically change oneself to cope with baldness are unrealistic and burdensome.

community What are we thinking about combining Oral AND Topical Minoxidil?

in Minoxidil 12 upvotes 3 months ago

Combining oral and topical minoxidil for hair loss may enhance results, but opinions vary on its effectiveness. Some users report benefits, while others see no added value; side effects like insomnia and increased body hair are noted.

community cb-03-01 research chem (winlevi/clascoterone cream)

in Technology 3 upvotes 2 years ago

The user is considering using CB or clascoterone for hair loss, potentially as an alternative to RU. They're also contemplating asking a dermatologist for topical clascoterone cream to apply to their temple.

community Anagenic is trying to compound Gt20029

in Treatment 56 upvotes 3 years ago

The conversation discusses concerns that Anagenic's version of GT20029 might not be as effective or safe as Kintor's, with comparisons to issues faced by pyrilutamide. The chemical structure of the drug has been published.

community What has the evidence been on side effects with CB?

in Research/Science 4 upvotes 5 years ago

Clascoterone (CB) shows an excellent safety profile with no serious side effects, but its effectiveness may decline after six months, making it more suitable as an adjunct treatment with finasteride and minoxidil rather than a standalone solution. Some argue it could be better than finasteride due to its protection against testosterone, but its long-term efficacy remains debated.

community Anyone have any KX-826 results yet?

in Product 14 upvotes 1 year ago

KX-826 users report increased shedding, with some experiencing more shedding at higher concentrations. Users are discussing where to purchase the product.

community PP405 (Everychem 3HP) Users - Assemble and share your story!

in Chat 19 upvotes 1 month ago

Users discussed the effectiveness of Everychem's solution, similar to PP405, with some reporting improved hair thickness and new growth. Concerns were raised about safety and the legitimacy of the product, with some users advising against purchasing research chemicals.

community Bicalutamide vs Finasteride for female AGA plus TE

in Female 3 upvotes 3 months ago

OP is considering Bicalutamide for female AGA and TE but is concerned about its side effects and effectiveness compared to Finasteride. OP is also using Minoxidil and Spironolactone but is experiencing significant shedding and is unsure if it's androgen-driven or due to Minoxidil changes.

community Solution vehicle used by compounding pharmacy

in Research/Science 1 upvotes 2 years ago

The user is using 0.1% dutasteride, 1% minoxidil with 2% procapil and 0.005% caffeine in the morning, and 1% minoxidil with 2% procapil and 0.01% tretinoin at night. They are concerned about the solution vehicle's effectiveness in preventing systemic absorption and ensuring the products stay around the hair follicles.

community how to compound topical cyclosporine

in Treatment 8 upvotes 3 years ago

The conversation is about compounding topical cyclosporine for hair loss, suggesting it needs an oil base like castor oil. The user seeks tips or tricks for the process.

community CB-03-01 / Breezula Personal Results

in Treatment 17 upvotes 4 months ago

The user shared their experience with CB-03-01 (Breezula/Clascoterone) for hair loss, noting reduced shedding and improved hair appearance but experiencing significant sleep disturbances and low energy due to HPA axis suppression. They decided to stop using it due to these side effects and are waiting for GT20029 as an alternative.

community Is finasteride mixable with this serum?

in Finasteride/Dutasteride 1 upvotes 1 year ago

The conversation discusses mixing finasteride (Essengen-F) with a multi-peptide serum for hair density. The main concern is whether these products can be used together safely.

community Couple of questions for hair fiber users

in Product 6 upvotes 4 years ago

User plans to use hair fibers regularly and asks about re-application, consistency, rain protection, and Boldify vs Toppik. Others provide advice and share experiences.

community Is anoying mixing pyrilutamide with another compound for full scalp coverage?

in Research/Science 6 upvotes 3 years ago

User uses 1ml RU58841 with 5ml stemoxydine for scalp coverage. Wants to switch to pyrilutamide and asks about mixing it with other compounds.

community clascoterone powder to topical diy

in Product 3 upvotes 1 month ago

The conversation is about making a topical solution from clascoterone powder, with references to using a RU58841 mixing guide for guidance. Concerns about product authenticity and bulk purchase requirements are also discussed.

community oral minoxidil collagen contradiction

in Minoxidil 13 upvotes 1 year ago

The conversation discusses concerns about oral minoxidil potentially aging the face by affecting collagen, questioning its systemic effects. The user has successfully used topical minoxidil for years and is hesitant to switch to oral minoxidil.

community PP405 (Everychem 3HP) users - assemble and share your updates!!

in Chat 44 upvotes 1 month ago

Users discussed experiences with Everychem's solution similar to PP405 for hair loss, noting some positive results like increased hair thickness and new growth. There was skepticism about the product's legitimacy and safety, with some users reporting early signs of effectiveness and others expressing concerns about the lack of evidence and safety profiles.

community A concern regarding the upcoming androgen degrader drug GT20029

in Chat 11 upvotes 1 year ago

GT20029 is a topical treatment that degrades androgen receptors to prevent hair thinning and loss, potentially offering fewer side effects than systemic treatments like finasteride. Concerns include its impact on hair texture and potential systemic effects, with market availability speculated in 3 to 5 years.