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A user shared their successful hair regrowth journey using 0.5 mg Dutasteride, 2.5 mg oral Minoxidil, and Biotin gummies, after switching from Finasteride due to insomnia. They highlighted the importance of brushing the scalp for blood flow and reported significant progress in four months without side effects.

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

A 22-year-old male experiencing diffuse thinning and frizzy hair has been using finasteride for nine months and is seeking advice on improving hair quality. Suggestions include using conditioners, biotin, rosemary oil, and addressing scalp conditions like seborrheic dermatitis or psoriasis, while finasteride may help reverse miniaturization and improve hair health.

Kintor Pharma finished enrolling and dosing participants in a Phase I trial for a hair loss treatment called AR-PROTAC (GT20029). The effectiveness of another drug, pyrilutamide (KX-826), for hair loss will be clearer after a Phase 2 trial expected to complete in January 2023.

Bicalutamide is discussed as a treatment for hair loss, particularly in females, with some users cautioning against its use due to potential side effects. The conversation also mentions using finasteride and other anti-androgens, with some users recommending more traditional treatments like dutasteride.

A 49-year-old user shared progress pictures after six months of using oral finasteride (1mg), oral minoxidil (2.5mg), and ketoconazole shampoo twice a week, reporting no side effects.

The user underwent a hair transplant in Turkey and has been using a topical solution with 5% minoxidil and 0.0025% finasteride, along with Ket 2% shampoo and derma rolling, to maintain hair status. They are uncertain about improvements, noting thicker non-transplanted hair, and are considering increasing medication frequency to enhance results.

Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.

The conversation is about a user's two-year hair loss treatment progress using 1mg oral finasteride daily, Kirkland minoxidil twice a day, and Nizoral 1% shampoo three times a week. The user reports no side effects and attributes most progress to finasteride and minoxidil.

A 17-year-old using 5% topical minoxidil experienced significant hair shedding after a year, possibly due to a "synchronization shed" and deficiencies in vitamin D and iron. Recommendations include continuing minoxidil, optimizing vitamin D and iron levels, and reducing tretinoin use if scalp irritation occurs.

Clascoterone (Breezula) shows a potential 500% increase in hair growth, possibly outperforming minoxidil and finasteride. It is in advanced trials, with hopes for FDA approval, but cost and side effects are concerns.

Bryan Johnson uses a custom hair loss treatment that includes topical finasteride, minoxidil, azelaic acid, diclofenac, tea tree oil, rosemary oil, ginkgo biloba, biotin, and melatonin, which have shown varying degrees of effectiveness with minimal side effects. He also undergoes PRP and laser therapy, and has tried dutasteride mesotherapy.

A 26-year-old male shared progress pictures after 4 months of treating hair loss with finasteride (1.25 mg on Mondays, Wednesdays, and Fridays), topical minoxidil twice daily, ketoconazole shampoo twice weekly, and weekly microneedling at 1.5 mm. He is seeing hair growth improvement, especially in the front, and is considering hair grafts for the crown area if necessary for more density.

The user shared their 14-month progress using 2.5mg Minoxidil, 1mg Finasteride, and 10mg Biotin daily, reporting significant hair growth and no side effects. They noticed results after 4 months and recommend continuing treatment for at least a year.

Ketoconazole may cause increased hair shedding. The user plans to use Minoxidil and dermastamping but cannot tolerate DHT blockers.

The user has been using oral finasteride daily, topical minoxidil twice a day, tretinoin once a week, and 2% ketoconazole twice a week since February 5th. They shared progress pictures showing hair improvement over two and a half months.

A 17-year-old in the UK seeks advice on mitigating hair loss until finasteride becomes an option at 19. Recommendations include using Minoxidil and considering other treatments like specific shampoos and dietary changes.

The user is experiencing positive hair growth after 3 months of using 5mg minoxidil, 1.1mg finasteride, and 1mg biotin, with noticeable beard thickening. They report no side effects and are encouraged to be patient for further results.

Hair loss treatments discussed include Minoxidil, Finasteride, and RU58841. HMI-115, a monoclonal antibody drug, is in phase 1 and 2 trials for different conditions, but its availability on the gray market is unlikely due to high production costs.

The user underwent two FUT hair transplant surgeries with subpar results, leading to disappointment and continued use of Minoxidil, laser cap, dermaroll, and biotin. They advise thorough research before committing to hair transplants, especially for those with advanced hair loss.

The impact of creatine on DHT levels, and whether it could cause accelerated male pattern baldness (MPB). The user taking a 5 alpha reductase inhibitor found that their DHT levels actually reduced despite taking creatine for nine weeks. Replies suggested looking into testosterone levels as well and debating the safety of creatine use in relation to MPB.

A 26-year-old is using 5% minoxidil twice daily and 1 mg finasteride every other day, along with biotin and collagen supplements, for hair regrowth. They apply minoxidil to the temples and crown and experienced initial shedding in the first month.

A 19-year-old male has seen no improvement in hair loss after 10 months on oral finasteride and 2 years on topical minoxidil, with hair thinning and a receding hairline continuing. One reply suggests getting tests to confirm if DHT is the cause of the hair loss.

The conversation is about using bicalutamide, taken less frequently than daily, for hair loss treatment. The user is considering 50mg every 3 days or once a week and is asking for others' experiences.

Dutasteride and finasteride are not effectively stopping hair loss for some users, despite long-term use. Some are considering or using RU58841, pyrilutamide, and other treatments like microneedling, while also managing seborrheic dermatitis with diet and topical solutions.

P5P supplementation helped reverse finasteride side effects, particularly by lowering prolactin levels and restoring sensitivity. The user experienced significant improvement within a day and full recovery in a few days.

A 22-year-old user experienced positive hair regrowth after 11 weeks using a spray containing 0.3% finasteride, 7% minoxidil, 2.2% ketoconazole, and 0.2% biotin. They reported initial side effects like scalp tingling and brief testicular pain, which subsided, and are considering switching to finasteride pills and a different minoxidil brand for cost reasons.

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

KY19382, a promising compound for hair loss, is not widely discussed or used. One user is currently testing it and plans to share results in a few weeks.

PP405, a topical LDH inhibitor, has shown to stimulate hair follicle stem cell proliferation in humans with moderate hair loss. They are advancing to more detailed trials this year.