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      community The mechanism of androgenic alopecia

      in Research/Science  34 upvotes 8 months ago
      DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

      community PP405 Hair Loss Drug: Phase 1 Human Results & Biopsy Insights

      in Research/Science  215 upvotes 1 year ago
      PP405 is a potential hair loss treatment undergoing trials, with discussions on its effectiveness and comparison to existing treatments like finasteride and minoxidil. There is skepticism about its status as a cure, with hopes for future advancements in genetic treatments like CRISPR.

      community Kintor develop GT20026 Anti-Androgen receptor drug with NO SIDES

      in Treatment  18 upvotes 5 years ago
      The conversation discusses GT20029, a new topical drug for hair loss and acne without notable side effects, which has been accepted for investigational use in China. Some users express skepticism about the legitimacy of the company and the potential for other drugs like RU58841 to be developed due to patent expiration and lack of profitability.

      community GT20029: How It Works for Hair Loss - Hair Loss “Cure”

      in Research/Science  33 upvotes 4 months ago
      GT20029 is a potential treatment for androgenetic alopecia, addressing the root cause by targeting androgen receptors, unlike Minoxidil or Finasteride. It is seen as a preventative measure rather than a regrowth agent, with hopes for market release soon.

      community PP405 2a study was a safety study. Some rational explaining.

      in Research/Science  22 upvotes 9 months ago
      The conversation discusses the safety study of PP405, emphasizing that early trials focus on safety rather than efficacy, and that any efficacy data from such a short study should be viewed skeptically. It also highlights that the information released is primarily for securing funding, and that meaningful efficacy results are expected in later phases.

      community Vicious male pattern baldness TINGLING ITCH!

      in Chat  9 upvotes 3 years ago
      A user struggles with male pattern baldness and a persistent tingling itch on their crown, trying various treatments like aloe vera, tea tree oil, and Nizoral without success. Another user suggests the itch might be psychosomatic, linked to worrying about hair loss.

      community Extreme caution: my experience using Ru58841 only once

      in Treatment  10 upvotes 1 year ago
      An 18-year-old experienced severe side effects, including heart palpitations and high blood pressure, after using RU58841 once, leading to a referral to cardiology for suspected left ventricular hypertrophy. The user regrets using RU58841 and seeks advice on recovery, while others suggest preexisting conditions or genetic predispositions may be factors.

      community Does pyrilutamide actually work?

      in Treatment  24 upvotes 3 years ago
      Pyrilutamide, a potential hair loss treatment, and how it compares to existing treatments such as Minoxidil, Finasteride and RU58841. Real-world results are being discussed to determine its effectiveness.

      community Is the clinic diagnosis legit to you ?

      in Transplants  1 upvotes 1 year ago
      The clinic diagnosed the user with NW3 and AGA, noting thinning hair despite using finasteride for 3 years, and suggested PRP and Mesotherapy before considering a transplant. The user questions the necessity of these treatments without confirming retrograde alopecia and its treatability.

      community Pyrilutamide from RUdirect, legit or fake?

      in Product  5 upvotes 1 year ago
      Pyrilutamide from RUdirect is discussed, with users sharing experiences and alternative sources like Koshinemall. Users mention using treatments like minoxidil, RU58841, and dutasteride for hair loss.

      community Tretinoin+Minoxidil heavy shedding. (31M)

      in Treatment  10 upvotes 2 years ago
      A person using Minoxidil, Finasteride, Microneedling, and recently added Tretinoin is experiencing heavy shedding and thinning hair. They suspect Tretinoin has made them respond to Minoxidil and are seeking others with similar experiences.

      community Betamethasone dipropionate 0.05 (sernivo spray)

      in General  76 upvotes 1 year ago
      A user was prescribed betamethasone dipropionate spray for a receding hairline, which caused skin peeling and depigmentation. They stopped using it and are considering alternatives like BPC-157/TB-500 for healing.

      community Female with hair loss - turns out it’s been thyroid cancer

      in Update  284 upvotes 2 years ago
      A woman with hair loss discovered she has thyroid cancer, which was found during an MRI and confirmed with an ultrasound. She advises others with symptoms to see a doctor and shares that her cancer was detected after her dog sniffed her neck and she experienced neck pain.

      community If I can’t tolerate 5ari, should I try Pyrilutamide 1%?

      in Treatment  4 upvotes 1 year ago
      The conversation is about considering pyrilutamide 1% as an alternative treatment for hair loss due to intolerance to 5-alpha reductase inhibitors. Some users suggest it might be effective, while others view it as a temporary solution.

      community Am I crazy or is this recovery?

      in Is this regrowth?  134 upvotes 1 year ago
      The user is experiencing sudden hair loss and is considering micro-needling, low-level light therapy, iron supplements, folihair, and Omega 3. They are hesitant to start finasteride, suspecting the hair loss might be due to telogen effluvium from a past COVID-19 infection.

      community Does low HGH leading to hairloss?

      in Research/Science  12 upvotes 2 years ago
      The user experiencing diffuse hair loss is using various treatments including RU58841, finasteride, minoxidil with tretinoin, anti-hair loss shampoo, and microneedling, and is considering adding peptides TB500, BPC157, and GHK-Cu. They have low growth hormone levels and are questioning its impact on hair loss, while another user suggests androgenic alopecia and androgens are likely the main cause of hair loss.

      community Mesenchymal Stem Cell Therapy (Exosome) Before & After

      in Treatment  2 upvotes 2 years ago
      A user's father experienced hair regrowth and other health improvements after two IV exosome treatments. The user also had four rounds of exosome therapy, noting significant hair regrowth and relief from headaches, but no change in gray hair.

      community Pyrilutamide vs Topical Finasteride

      in Finasteride/Dutasteride  5 upvotes 7 months ago
      Topical finasteride is currently more effective than pyrilutamide for hair loss. Combining treatments like topical finasteride and pyrilutamide may enhance results due to different mechanisms.

      community DIY copper peptide for microneedling?

      in Product  3 upvotes 6 months ago
      The conversation is about using DIY copper peptide (GHK CU) serum for microneedling to address hair loss, with additional treatments including Nizoral for DHT reduction and red light therapy. The user is considering adding Minoxidil but is concerned due to having cats.

      community Sweet Lord my DHT itch is finally gone

      in Chat  49 upvotes 3 years ago
      Hair loss itch stopped by adding RU58841 to treatment. Topical Finasteride and Pyrilutamide also mentioned as potential itch solutions.

      community Where is GT20029 already? Grrrr

      in Research/Science  20 upvotes 2 years ago
      The conversation is about frustration over the delay in phase 2 results for a hair loss treatment called GT20029. One user suspects the treatment may have failed.

      community Bad news about GT20029 from Anagen Inc

      in Treatment  11 upvotes 3 years ago
      The conversation is about the difficulty in obtaining GT20029, a hair loss treatment, due to patent issues and the need to resort to group buys or Chinese labs for acquisition. Specific treatments mentioned include Minoxidil, finasteride, and RU58841.

      community Looking for KX826 (pyrilutamide) success stories

      in Treatment  12 upvotes 1 year ago
      A user ordered pyrilutamide (KX826) to stop hair loss and is seeking success stories. Replies indicate that it's too early to evaluate the product's effectiveness, as it takes several months to see results.

      community Let's talk about Tsuji and Shiseido

       5 upvotes 7 years ago
      The conversation discusses hair loss treatments, focusing on Tsuji's hair cloning and Shiseido's RCH-01, with skepticism about their effectiveness on humans. It compares these to PRP, noting PRP's higher efficacy in studies.