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      community Can we get a reality check on PP405?

      in Research/Science  83 upvotes 5 months ago
      PP405 is a promising hair loss treatment that may outperform minoxidil and finasteride by reviving dormant follicles and promoting significant regrowth. Results from ongoing trials are awaited, with a potential market release between 2028-2030.

      community Story time! The Great Unbalding (PP405)

      in Research/Science  235 upvotes 5 months ago
      PP405 is a promising new hair loss treatment that may reactivate dormant hair follicles without side effects. It could surpass traditional treatments like minoxidil and finasteride if successful in further trials.

      community People who don’t microneedle, why?

      in Microneedling  143 upvotes 5 months ago
      Microneedling is often combined with minoxidil for hair growth, but concerns about scalp damage, pain, and effectiveness deter some users. Alternatives like finasteride, dutasteride, tretinoin, and laser treatments are preferred by others.

      community 4 months on finasteride + minoxidil

      in Progress Pictures  293 upvotes 5 months ago
      The user experienced significant hair improvement after four months using oral finasteride, topical minoxidil, and a daily caffeine shampoo, with no side effects. The discussion includes varying opinions on the effectiveness and side effects of finasteride.

      community The Health Benefits of Head Hair

      in Research/Science  19 upvotes 6 months ago
      Hair provides protection against head trauma, reduces skin cancer risk, helps remove heavy metals, and aids in wound healing. The conversation emphasizes the health benefits of maintaining head hair beyond cosmetic reasons.

      community The amazing fast pace of PP405.

      in Chat  327 upvotes 6 months ago
      PP405 is a new hair loss treatment advancing quickly in trials, generating excitement and skepticism about its effectiveness and marketing claims. Some see it as a potential alternative to minoxidil and finasteride, but concerns about long-term effects and the need for DHT blockers persist.

      community How likely do you think it is for PP405 to come out?

      in Research/Science  21 upvotes 6 months ago
      PP405 is a potential new hair loss treatment that works through metabolic pathways rather than hormonal ones, with an estimated market release between late 2027 and 2029. Current alternatives to finasteride include minoxidil, pyralutamide, fluridil, and RU58841, with hair transplants also being a viable option.

      community How to cope with starting fin/dut too late

      in Chat  9 upvotes 6 months ago
      Regret over not starting hair loss treatments like finasteride and minoxidil earlier, leading to significant hair loss. Users discuss coping strategies, including buzzing hair, staying on medications, and considering future treatments.

      community My almost 9 year journey with finasteride and minoxidil

      in Progress Pictures  273 upvotes 6 months ago
      A user shared their 9-year experience with finasteride and 3 years with oral minoxidil, noting positive hair maintenance and regrowth without significant side effects. They are considering a hair transplant but are generally satisfied with their current hair condition.

      community Can we stop fear mongering with finasteride

      in Finasteride/Dutasteride  285 upvotes 6 months ago
      Finasteride is effective for hair loss but can cause sexual dysfunction and mental health issues in some users, leading to a polarized debate on its risks. Some switch to alternatives like Dutasteride or topical treatments to avoid side effects.

      community Topical dutasteride is superior to oral finasteride

      in Research/Science  96 upvotes 6 months ago
      Topical dutasteride is more effective than oral finasteride for male pattern hair loss, with fewer side effects. Some prefer oral treatments for convenience, while others use topical solutions like minoxidil and dutasteride, sometimes with microneedling, for better results.

      community 26 months progress – major improvement and stability

      in Progress Pictures  344 upvotes 6 months ago
      A 36-year-old achieved significant hair improvement and stability over 26 months using oral finasteride, minoxidil foam, microneedling, and ketoconazole shampoo, with no side effects. Patience and consistency were crucial for increased hair density and reduced shedding.

      community The mechanism of androgenic alopecia

      in Research/Science  33 upvotes 6 months ago
      DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

      community New 2025 study: high dose oral minoxidil (up to 10mg)

      in Research/Science  80 upvotes 6 months ago
      High-dose oral minoxidil (>5 mg/day) can increase hair density in some men with androgenetic alopecia, but side effects like extra body hair and heart issues are common. Gradual dose increase is advised, but adverse effects may lead to discontinuation or dose adjustments.

      community 7 months using Dutasteride Horror, before and after

      in Minoxidil  51 upvotes 6 months ago
      The user experienced significant hair loss after starting dutasteride, despite improved libido and gym performance. They previously used finasteride but stopped due to side effects and are considering combining treatments or a hair transplant.

      community Creatine and hair loss (personal experience)

      in Update  97 upvotes 6 months ago
      Creatine can cause increased hair loss in some people, particularly those with a predisposition to androgenic alopecia, but hair loss often stops after discontinuing its use. Some users experience no hair loss while using creatine.

      community One year off fin/min and I regret it

      in Update  417 upvotes 6 months ago
      The user regrets stopping finasteride and minoxidil due to side effects but plans to resume treatment. They consider using finasteride every other day and continuing topical minoxidil to manage side effects while maintaining hair.