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GlossaryDecorin

small proteoglycan that regulates collagen fiber formation

Decorin is a small proteoglycan found in the extracellular matrix of connective tissues. It plays a crucial role in regulating collagen fibrillogenesis, which is the process of collagen fiber formation, and helps maintain the structural integrity of tissues. Additionally, decorin has been shown to influence cell growth and wound healing, making it significant in both normal physiological processes and pathological conditions.

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community Is this basically the closest thing to a cure? I don’t know why more men don’t use wigs. Thought?

in Hair Systems 1089 upvotes 1 year ago

Wigs are considered a temporary solution for hair loss, with concerns about cost, maintenance, and social stigma. Many prefer treatments like finasteride, minoxidil, or hair transplants for more permanent results.

community clascoterone powder to topical diy

in Product 3 upvotes 2 months ago

The conversation is about making a topical solution from clascoterone powder, with references to using a RU58841 mixing guide for guidance. Concerns about product authenticity and bulk purchase requirements are also discussed.

community Carrier for homemade topical Finasteride

in Chat 4 upvotes 2 years ago

The conversation is about making topical finasteride using stemoxydine as a carrier. The user is considering buying Redken Cerafill Hair Re-Densifying Treatment (Stemoxydine) 90ml for this purpose.

community Clascoterone is the way to go if you cannot use DHT blockers

in Chat 11 upvotes 1 month ago

Clascoterone is suggested as an alternative for those who experience side effects from finasteride and dutasteride. It is not widely available yet, but some users are obtaining it from compounding pharmacies or suppliers like Echemi.

community Adding the final piece to my fin/min/derma stamp routine

in Ketoconazole 6 upvotes 1 year ago

The user has been using finasteride, minoxidil, and a derma stamp for 3 months with significant improvement. They are now adding ketoconazole to their routine.

community Anyone has experienced Collagen Synthesis with min ? (wrinkles, dark circles...)

in Question 11 upvotes 7 years ago

Minoxidil may cause wrinkles and dark circles, which some users report can be mitigated by adjusting dosage. Reactions vary, and while some dismiss these side effects, others experience significant changes.

community RESULTS: 1% Clascoterone Cream. (3 months Jan-Mar 2026)

in Progress Pictures 15 upvotes 3 months ago

The user reported slight improvement in hairline using 1% Clascoterone cream over three months but found it too costly to continue. They expressed interest in trying a 5% concentration if it becomes available at a reasonable price.

community Dim: high estradiol levels what to do

in Chat 8 upvotes 1 year ago

A user is experiencing facial bloating from low-dose topical finasteride due to high estradiol levels and is seeking advice on using DIM to manage this issue, including dosage and brand recommendations.

community Minxodil collegen synthesis decrease?

in Minoxidil 3 upvotes 2 years ago

Minoxidil may age skin by slowing collagen synthesis, but using collagen peptides and a basic skincare routine might counteract this. Foam minoxidil could reduce systemic absorption and avoid alcohol-related side effects.

community the ordinary retinol & minoxidil

in Minoxidil 13 upvotes 1 year ago

Using retinol with minoxidil may not be as effective as tretinoin, but retinaldehyde or adapalene could be alternatives. A micro-roller with minoxidil is suggested for better results.

community Anyone using Finastopic (no pg Isdin)?

in Product 2 upvotes 2 years ago

The conversation discusses the use of Finastopic, a carrier for finasteride solutions by Isdin, and compares it to a standard propylene glycol (PG) solution. The user was prescribed a 1% finasteride solution using Finastopic and has been using a self-compounded 0.025% topical finasteride with minoxidil.

community And just like that, everyone stopped talking about Clascoterone?

in Research/Science 27 upvotes 4 months ago

Clascoterone showed promising initial results for hair regrowth but failed to replicate them, leading to disappointment. Users discuss combining it with minoxidil and other treatments, noting its current availability only in lower concentrations.

community Derma roll, tretinoin, minoxidil

in Research/Science 3 upvotes 1 year ago

Use tretinoin three times a week, dermaroll once a week, and apply minoxidil daily, but avoid using all three on the same day. Tretinoin is preferred over hydrocortisone and should not be used immediately after dermarolling.

community two months on 2-deoxy-d-ribose (2ddr)

in Progress Pictures 10 upvotes 1 year ago

The conversation discusses hair regrowth using 2-deoxy-d-ribose (2DDR) combined with minoxidil, with some users noting new hair growth. The original poster has been using minoxidil for 12 years and is considering combining 2DDR with finasteride, despite past side effects.

community Clinical Trial: Clascoterone (Cortexolone 17A-Propionate)

in Research/Science 24 upvotes 2 years ago

A user is joining a clinical trial for Clascoterone, a drug approved for acne but being tested for hair loss. They previously tried finasteride with limited success and plan to share updates on their experience with the new treatment.

community Question about clascoterone acne cream

in Treatment 2 upvotes 2 months ago

Clascoterone cream can be used on the scalp, but it may not be effective due to its dosage. AR antagonists like clascoterone are generally less effective than 5AR inhibitors for hair loss.

community Clascoterone 5% solution infographic

in Update 132 upvotes 6 months ago

Clascoterone 5% solution is discussed as a potential new treatment for hair loss, offering an alternative for those who can't use finasteride or need additional options beyond minoxidil. Concerns about cost, effectiveness, and safety compared to existing treatments like RU58841 and finasteride are highlighted.

community Topical min and dermarolling with seborrheic dermatitis

in Minoxidil 4 upvotes 2 months ago

The user is managing hair loss with oral finasteride, recently switching to dutasteride, and topical minoxidil, but faces challenges due to seborrheic dermatitis. They seek advice on effective regrowth methods that don't worsen their condition, with suggestions including various shampoos like Vichy Dercos and ketoconazole.

community Clascoterone phase 3 results are out!

in Treatment 83 upvotes 6 months ago

Clascoterone phase 3 results show promising improvements in hair count, but concerns about high costs and lack of detailed data remain. Users compare it to existing treatments like Minoxidil and Finasteride, expressing skepticism about its accessibility and effectiveness.

community Clascoterone 5% Delivers Strong Phase 3 Hair-Growth Results | Dermatology Times

in Research/Science 45 upvotes 6 months ago

Clascoterone 5% shows promising hair growth results but is criticized for high cost and unclear effectiveness compared to other treatments like finasteride. Glenmark is testing a combination of Clascoterone 7.5% and Minoxidil 5% in India.

community Just got my Dualgen-5R, the one with retinoic acid (tretinoin) but without the fin.

in Minoxidil 6 upvotes 5 years ago

The user has been using Minoxidil and finasteride with success and is now trying Dualgen-5R with retinoic acid but without finasteride, along with microneedling. They plan to share results in 5-6 months.

community Scalp barrier support while using min foam? +Seb derm

in Minoxidil 1 upvotes 1 month ago

The user started using minoxidil foam daily after two years on finasteride and is managing seborrheic dermatitis with antifungal shampoo. They seek advice on moisturizing products that won't worsen their condition, with suggestions including gentle shampoos and light ceramide serums.

community 3 years of irregular derma rolling and min/Redensyl

in Progress Pictures 4 upvotes 2 years ago

The conversation is about someone's three-year experience with irregular derma rolling, Minoxidil, and Redensyl for hair loss, hoping to thicken areas with fine hair.

community Taking part in a Clascoterone Study

in Treatment 6 upvotes 2 years ago

The conversation is about a person considering participating in a study for Clascoterone, a topical cream for hair loss, and seeking advice on potential side effects. They have mild hair loss and are not currently using other treatments like finasteride.

community Kintor's email response to me, regarding false advertising, and my proposal for them to develop a topical dut formulation with meaningful efficacy.

in Treatment 46 upvotes 1 year ago

Kintor apologized for using misleading images in their advertisements and promised stricter review processes. They are also considering developing a topical dutasteride formulation.

community making a clascoterone lotion from powder

in Technology 2 upvotes 1 year ago

A user is considering making a 2% clascoterone lotion from powder due to unavailability in their location. They plan to mix clascoterone powder with retinol lotion and use literature to determine the correct dosage.

community redensyl - follicle stem cell activator any experiences?

in Question 8 upvotes 9 years ago

A Swiss product called Redensyl, which is supposed to target hair follicle stem cells and has recently been marketed in Europe. The post inquires if anyone has had any experience with the product.

community Anybody heard about clascoterone against hair loss?

in Research/Science 3 upvotes 1 year ago

Clascoterone, an acne treatment that blocks DHT, is being developed for scalp use against hair loss. The conversation also mentions Minoxidil, finasteride, and RU58841 as treatments.

community DIM + Calcium d-Glucarate (lowering Estrogen)

in Chat 4 upvotes 3 years ago

Using DIM and Calcium D-Glucarate to reduce finasteride side effects. Discussion includes dosage, brand, and product effectiveness.

community Im struggling with sebderm need help

in Product 3 upvotes 4 months ago

The user is struggling with seborrheic dermatitis and plans to try ciclopirox olamine after finding ketoconazole too drying. They are also using finasteride daily.