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      community Comparing the effect of T suppression and DHT suppression

      in Transgender  89 upvotes 1 year ago
      The conversation discusses the use of 5-alpha-reductase inhibitors like finasteride and dutasteride for hair loss in transgender women, particularly in relation to testosterone suppression. The original poster has been using dutasteride and is considering stopping it due to undetectable testosterone levels.

      community My Dermatologist literally lied to me!

      in Update 7 months ago
      A dermatologist prescribed 1mg Finasteride daily and 5% topical Minoxidil for hair loss, stating results would appear in 3 months, but later clarified it could take 1-2 years for full effects. The user is frustrated with the slow progress and feels misled about the timeline.

      community Both photos are 10 months apart

      in Progress Pictures  193 upvotes 4 months ago
      The user experienced hair regrowth using finasteride and minoxidil over 8 months, with noticeable improvements starting in June. They reported side effects like erectile dysfunction and flakes but continued treatment as the effects were not permanent.

      community Just saw a post from a hyper responder to topical minoxidil and wanted to show my experience.

      in Progress Pictures  4 upvotes 1 month ago
      A user shared their 1-year and 3-month hair loss treatment progress using 0.5mg Dutasteride daily, topical and then oral Minoxidil, and microneedling, noting hair darkening and some side effects like watery semen and testicular pain. Despite initial setbacks after switching to oral Minoxidil, they are seeing progress and plan to increase the dosage.

      community Why was fluridil abandoned and never made past phase 2?

      in Chat  4 upvotes 4 years ago
      Fluridil was abandoned due to its weak effectiveness and low binding affinity to the androgen receptor, making it less competitive against DHT and testosterone. Users discuss its limited results compared to other treatments like pyrilutamide and RU58841.

      community its possible! dont give up. Its never too late

      in Progress Pictures  272 upvotes 8 months ago
      A user shared their successful hair regrowth journey using finasteride, minoxidil, microneedling, and castor oil, highlighting the importance of persistence despite initial shedding. They reported no side effects and encouraged consistency in treatment.

      community How would you react if PP405 isn't successful in phase 3 trials?

      in Chat  23 upvotes 6 months ago
      People are discussing their reactions if PP405 fails in phase 3 trials, with some expressing skepticism and others holding onto hope for future treatments like GT20029 and Breezula. Many mention continuing with existing treatments like minoxidil and finasteride, while others express disappointment and consider alternative solutions.

      community Trying to regrow crown been on Fin for 4.5 years

      in Finasteride/Dutasteride  6 upvotes 2 years ago
      The user has been on finasteride for 4.5 years and minoxidil for 10 years, maintaining hair but not regrowing much on the crown and temples. They are considering using a dermastamp more frequently and possibly trying RU58841, but are hesitant about dutasteride due to concerns about side effects and DHT suppression.

      community Finasteride and long term regrowth

      in Finasteride/Dutasteride  41 upvotes 1 month ago
      Finasteride can lead to hair regrowth beyond the first year, with some users experiencing improvements for several years, though results vary. Most regrowth occurs in the first 1-2 years, but some continue to see gradual improvements over time.

      community Almost 4 Months dutasteride, min and derma stamp

      in Progress Pictures  390 upvotes 2 years ago
      The conversation is about a user's nearly 4-month hair loss treatment regimen, which includes dutasteride every other day, 0.25ml minoxidil on the hairline once a day, and using a 1.5 mm derma stamp every two weeks. Some responses question the need to start multiple treatments simultaneously, while others comment on the visible improvement and the necessity to continue treatment for sustained results.

      community 1+ year Nuclear Stack on 19M, AMA!

      in Update  112 upvotes 1 year ago
      A 19-year-old is using oral dutasteride, topical minoxidil, and dermastamping to address hair loss and enhance facial hair growth, experiencing minimal side effects and increased body hair. They report positive results in hairline thickness and temple closure.

      community Dutasteride+Minox/11 months progress

      in Is this regrowth?  34 upvotes 5 months ago
      The user has been using finasteride for 7 months, switched to dutasteride for 4 months, and has been applying topical minoxidil once daily for 11 months, resulting in noticeable hair regrowth and improved hair health. The user experienced some shedding after switching to dutasteride but reports no side effects and improved skin condition.

      community Diffuse Thinners: When to add to stack?

      in Finasteride/Dutasteride  8 upvotes 1 year ago
      A user experiencing diffuse thinning at the hairline after 12 months on finasteride is considering adding minoxidil, dutasteride, or RU58841 to their treatment. Another user suggests adding minoxidil now, holding off on dutasteride, and shares personal side effects from RU58841.

      community 8 months progress. Slow and steady progress

      in Progress Pictures  190 upvotes 2 months ago
      The user has been using finasteride and topical minoxidil for 8.5 months, with initial progress slowed due to stopping microneedling. They plan to resume microneedling and consider a hair transplant in the future.

      community Progress of my crown from 13 Dec 2025 to 13 May 2026.

      in Progress Pictures  63 upvotes 4 weeks ago
      A user shared their hair regrowth progress using 1 mg finasteride, 10% minoxidil with 0.1% finasteride solution, and derma rolling, noting significant improvement in crown density over five months. They experienced initial shedding but reported no side effects from finasteride and plan to continue treatment for 10-11 months before deciding on future steps.

      community ~6-7 month progress. November 2025 - May 2026

      in Progress Pictures  33 upvotes 3 weeks ago
      The user experienced significant hair regrowth using finasteride alone over 6-7 months, despite initial side effects like reduced sexual desire and acne. They are considering reducing the dosage to manage side effects and have also used ketoconazole shampoo weekly.

      community Switch now or wait until later

      in Finasteride/Dutasteride  4 upvotes 1 month ago
      The conversation discusses whether to switch from Finasteride to Dutasteride for hair loss treatment. Some suggest switching to Dutasteride now due to its effectiveness, while others recommend waiting to see how Finasteride performs, especially if there are no side effects.

      community 18 month apart - been on Fin for 3 years, feel like in the last 18 months I’ve lost some ground. Black top is today.

      in Update  22 upvotes 1 month ago
      The user has been using finasteride for three years and topical minoxidil, and while they feel they've lost some ground in the last 18 months, most responses suggest their hair looks the same or even fuller. The general consensus is that the treatments have maintained the hair well, with some users suggesting additional treatments like derma stamping or dutasteride for further improvement.

      community 2-deoxy-D-ribose (2dDR), a sugar molecule, was found to be 80%-90% as effective as minoxidil in promoting hair growth and neovascularization in androgenic alopecia models, showing promise for alopecia treatment.

      in Research/Science  18 upvotes 1 year ago
      2-deoxy-D-ribose, a sugar molecule, is found to be 80%-90% as effective as Minoxidil in promoting hair growth, showing potential for alopecia treatment. Concerns include high cost, lack of human studies, and possible side effects like diarrhea and nausea.

      community ORAL MIN ,DERMAROLLING AND RU58841 PROGRESS 3 months (18,M)

      in Progress Pictures  80 upvotes 3 years ago
      The conversation is about an 18-year-old's progress with hair regrowth using oral Minoxidil, dermarolling, and RU58841 over three months, starting treatment after beginning to lose hair at 16. Participants are impressed with the improvement and encourage continued treatment.

      community RU58841 One month difference comparison

      in Progress Pictures  128 upvotes 5 years ago
      The conversation discusses the use of RU58841 for hair loss, with one user sharing a one-month difference in their hair after using it. Users discuss where to buy RU58841, potential side effects including heart issues, and mixed opinions on its effectiveness, with some questioning the need for treatment based on the before and after pictures.

      community Six month (and six days) update

      in Update  8 upvotes 2 years ago
      A 59-year-old man with significant hair loss has seen some improvement, including reversal of Retrograde Alopecia and darkening of hair, after switching to RU58841 and a new minoxidil base solution with additional ingredients. He also changed from a derma roller to a derma stamp for application.

      community What has your 0.5mg/daily dutasteride timeline been?

      in Research/Science  34 upvotes 1 year ago
      Many users report switching from finasteride to dutasteride with mixed results, often experiencing increased shedding and minimal regrowth. Some users find dutasteride more effective in slowing hair loss, while others see no improvement or even regression.

      community Crown progress Nov 2024 to March 2025. Full recovery possible?

      in Progress Pictures  279 upvotes 1 year ago
      A 29-year-old is using liposomal topical finasteride/minoxidil and low-level light therapy (LLLT) to improve hair growth, showing significant progress in crown recovery. The user prefers liposomal topicals to avoid side effects from oral finasteride and uses the iRestore Essential device for LLLT.

      community Dut only 0.5 mg, age 30 to 32,

      in Progress Pictures  106 upvotes 10 months ago
      A user shared their experience using dutasteride for hair loss, noting subtle improvements and thicker hair without significant regrowth. They did not use finasteride or minoxidil, and experienced occasional shedding but no side effects.