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      community PP405 Update and My Take on Pelage

      in Research/Science  86 upvotes 5 months ago
      Pelage Pharmaceuticals raised $120M for their hair loss treatment, PP405, showing strong investor confidence despite limited data. There is skepticism about its efficacy and long-term effects compared to treatments like GT20029.

      community Dht kills hair, but no one says why?

      in Finasteride/Dutasteride  40 upvotes 7 months ago
      DHT affects hair follicles, contributing to hair loss, but the exact mechanism is unclear. Treatments like finasteride and minoxidil are used to manage hair loss, though they may have side effects and varying effectiveness.

      community Federal Grant Cuts have impacted PP405 related research

      in Technology  457 upvotes 7 months ago
      Federal funding cuts have delayed PP405 research, affecting hair loss treatment progress, though clinical trials will continue. The discussion highlights PP405's potential compared to minoxidil and finasteride and stresses the importance of government-funded research.

      community Summary of Procapil video by Haircafe

      in Minoxidil  2 upvotes 8 months ago
      Procapil is marketed as a natural hair loss treatment but lacks strong evidence and is industry-biased. Minoxidil and Finasteride are the only FDA-approved treatments for androgenetic alopecia.

      community How true is the statement: dead follicles don't grow back?

      in Research/Science  111 upvotes 1 year ago
      Hair follicles usually go dormant rather than die, and treatments like finasteride, minoxidil, and hormone therapy can sometimes reactivate them, though results vary. Complete regrowth is rare, especially in long-term bald areas, but some individuals see significant improvement with these treatments.

      community Unpopular Opinion: hair cloning kind of sucks as a potential future cure.

      in Technology  27 upvotes 1 year ago
      Hair cloning is seen as a distant and potentially less relevant solution for hair loss due to its high cost, invasiveness, and the advancement of other treatments like Minoxidil and finasteride. Many believe that by the time hair cloning becomes viable, other less invasive and more effective treatments will be available.

      community Being Safe on Oral Minoxidil: tl;dr on the literature.

      in Research/Science  51 upvotes 1 year ago
      Oral minoxidil is effective for hair loss but can cause cardiovascular side effects, such as pericardial effusion, especially in those with genetic predispositions. Starting with low doses and monitoring cardiovascular health are advised to reduce risks.

      community PP405 Might Be the Closest We Have to a Upcoming Cure

      in Technology  237 upvotes 1 year ago
      PP405 is considered a promising potential cure for hair loss, with phase 2 trial results expected in February 2025. Hair cloning is also discussed as a potential ultimate solution, despite significant scientific challenges.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Do we have to be junkies? That's funny

      in Research/Science  13 upvotes 1 year ago
      The conversation discusses using finasteride, dutasteride, minoxidil, cialis, and metformin to protect hair and health. Some users caution against self-prescribing these drugs due to potential risks and complications.

      community How does dutasteride regrowth work?

      in Finasteride/Dutasteride  7 upvotes 1 year ago
      A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

      community How all hormones affect our hair follicles. Not just DHT. Take a look at this paper. Prolactin, melatonin, cortisol, progesterone, testosterone and more

      in Research/Science  126 upvotes 3 years ago
      The conversation discusses various factors affecting hair loss, not just DHT, and mentions treatments like Minoxidil, finasteride, and melatonin. Some users report personal experiences with these treatments and hormone tests, while others speculate on the role of hormones like prolactin and cortisol in hair loss.

      community This is the best time in human history to be fighting hair loss

      in Treatment  192 upvotes 3 years ago
      This conversation discusses the advancements in treatments for hair loss, including finasteride, dutasteride, minoxidil and new promising treatments such as pyrilutamide and verteporfin. Other treatments discussed were taking minoxidil orally, tretinoin to turn non-responders into responders and microneedling to further boost growth.

      community It's crazy how it's 2018 and the only hair loss treatments we have feature undesirable side effects and/or aren't even effective for many people.

       133 upvotes 7 years ago
      Hair loss treatments, including minoxidil, dermarolling, finasteride, dutasteride, hair transplants, hair systems, and shaving the head. The conversation covers various opinions on these treatments and mentions possible side effects as well as alternatives like wigs, vitamins, and lifestyle changes. The post expresses disappointment that there has been no major breakthrough in the field of hair loss treatments despite decades of research.

      community Fevipiprant 2019!

       15 upvotes 9 years ago
      The conversation discusses Fevipiprant, an asthma drug that may block CRTH2 and potentially stop male pattern baldness (MPB) without inhibiting DHT. It also mentions the use of finasteride and dutasteride for hair loss.

      community What’s the deal with microneedling?

      in Microneedling  15 upvotes 1 month ago
      A 26-year-old uses topical minoxidil, oral finasteride, and Nizoral shampoo for hair thinning and is considering microneedling but is unsure about the best approach. Users suggest using a 1.0mm dermaroller once a week, cautioning against overuse due to potential scarring, and some recommend combining microneedling with minoxidil for better absorption.

      community When is the cure gonna drop , how much more time

      in Research/Science  112 upvotes 1 month ago
      There is no imminent cure for hair loss, but treatments like Minoxidil, Finasteride, and new drugs such as KX-826, GT-20029, and PP405 are being explored. Current solutions focus on slowing hair loss and stimulating growth, with hopes for better options in the future.

      community Fix/min after 9 months - can you spot the difference?

      in Is this regrowth?  141 upvotes 3 months ago
      The user experienced significant hair regrowth after using minoxidil for 9 months and finasteride for 3 months, with plans to continue treatment and possibly get a hair transplant. Some users suggested adding microneedling and other treatments, while others discussed potential side effects of finasteride.

      community Derm stopped me from using Minoxidal

      in Update  53 upvotes 5 months ago
      A dermatologist advised stopping minoxidil due to heavy shedding, suggesting alternative treatments like Betaval Lotion and supplements, but many users disagreed, recommending continuing minoxidil and adding finasteride for better results. The conversation highlights skepticism about the dermatologist's motives and emphasizes the importance of understanding the type of hair loss before choosing treatments.

      community It's always the Mice that gets to grow back hair.

      in Research/Science  431 upvotes 5 months ago
      Sodium dodecyl sulfate, oleic acid, and palmitoleic acid may promote hair growth, but their safety and effectiveness for humans are uncertain. Users consider trying these treatments cautiously, exploring alternatives like ostrich oil and microneedling.

      community Why don’t more people use hair fibers?

      in Product  527 upvotes 5 months ago
      Hair fibers can effectively cover thinning hair when used with minoxidil and hairspray but require daily application and can be inconvenient in certain conditions. Some users prefer treatments like finasteride, dutasteride, microneedling, or wigs due to the maintenance and limitations of hair fibers.