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PP405, a topical LDH inhibitor, has shown to stimulate hair follicle stem cell proliferation in humans with moderate hair loss. They are advancing to more detailed trials this year.

The user started treating their slightly thinning, receded hairline with a serum containing Redensyl and other ingredients, and dermarolling weekly. They recently began taking finasteride and plan to stop Redensyl in the future to test if hair loss resumes.

A user is creating a custom topical hair regrowth serum using minoxidil, bimatoprost, tretinoin, castor oil, and hyaluronic acid. They are also using dutasteride, oral minoxidil, and castor oil in their current regimen.

A 22-year-old has been using dutasteride (0.5 mg daily) for over a year but is experiencing increased hair shedding, scalp inflammation, and burning, and cannot use minoxidil due to side effects. Suggestions include consulting a dermatologist, trying oral minoxidil, microneedling, rosemary oil, caffeine shampoo, and considering other treatments like PRP or red light therapy.

User reports using a derma roller daily, seeing new hair growth along the hairline without using Minoxidil or finasteride. They seek advice on further promoting hair growth with their current routine.

The user has been using oral dutasteride 0.5mg, oral minoxidil 2mg, and topical minoxidil 5% for hair regrowth, along with microneedling. They have seen significant hair coverage improvement and are considering additional supplements for better results.

A user is frustrated that their dermatologist requires blood and sperm tests before prescribing oral finasteride, despite already taking oral minoxidil. They prefer oral medication over topical treatments due to sensory issues and are considering asking their GP for a finasteride prescription or seeking alternatives online.

The conversation discusses using homemade topical finasteride for hair loss, showing an increase in DHT levels despite treatment. The user applies 0.125mg daily, resulting in 113.4% of previous DHT levels.

The user has been using topical 5% Minoxidil, 0.1% Finasteride, dermastamping, 2% ketoconazole, and a DHT-blocking shampoo with saw palmetto, caffeine, biotin, and argan oil for hair loss. Despite some baby hair growth on one side, the user is experiencing continued hairline recession and shedding, leading to distress.

The user switched from finasteride to 2.5 mg dutasteride daily and added 1% pyrilutamide to address persistent scalp itch, but the itch remains. They also use 2% ketoconazole and 2.5% selenium sulfide shampoo for temporary relief.

The user struggles to cover their entire scalp with 1 ml of RU58841 while using dutasteride and oral minoxidil for hair loss. Suggestions include using a syringe for precise application, applying twice daily, and considering the use of more than 1 ml to ensure full coverage.

The conversation discusses using azelaic acid to reduce scalp inflammation while using RU58841 for hair loss. It suggests applying azelaic acid in the morning and RU58841 at night to avoid degradation, while also using dutasteride and minoxidil.

A 21-year-old is experiencing aggressive hair loss and dandruff, possibly due to seborrheic dermatitis, and is using pumpkin seed oil, scalp massages, and anti-dandruff shampoo as treatments. They are hesitant to use prescribed Finasteride and Minoxidil and have noticed some improvement after stopping Serenoa capsules.

The user is addressing hair loss with finasteride, dutasteride, oral and topical minoxidil, dermarolling, and shampoos. They are considering adding essential oils to improve circulation.

RU58841 is discussed as a potential treatment for acne and hair loss, with users debating its effectiveness and safety compared to other treatments like finasteride, minoxidil, and dutasteride. Concerns about RU58841's side effects and lack of clinical trials are raised, while some users share their personal experiences and routines involving RU58841 for hair loss.

Veradermics' oral minoxidil shows promise for hair regrowth, with some users reporting significant improvements, while Pelage's PP405 results are less convincing and lack transparency. There is skepticism about both treatments' long-term effectiveness and potential side effects.

Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.

The conversation is about using a topical spray containing minoxidil, finasteride, and tretinoin for hair regrowth over six months, with positive results and minimal side effects. The user also mentions using biotin and alpecin, and discusses the benefits of topical application over oral forms.

The user is experiencing diffuse androgenic alopecia and is trying various treatments, including 5mg finasteride, loniten, and Formula 82D, which contains dutasteride, a steroid, and tretinoin. They report potential regrowth with Formula 82D, despite previous treatments being ineffective.

The conversation is about finding a solution for scalp inflammation related to AGA, with the user expressing frustration that Minoxidil and Finasteride do not address inflammation. The user has researched glucocorticoids and topical NSAIDs for reducing inflammation and seeks advice from specialists.

A 28-year-old male, previously on dutasteride for hair loss, is considering oral minoxidil or a compounded treatment of minoxidil, finasteride, and tretinoin after noticing hairline recession. The dermatologist suggested oral minoxidil and mentioned a compounded option, but the user is unsure about its benefits compared to current treatments.

The conversation humorously discusses using off-label drugs like Minoxidil, finasteride, and RU58841 for hair growth. It jokes about the brain absorbing these treatments for maximum keratin production.

The user reported slight improvement in hairline using 1% Clascoterone cream over three months but found it too costly to continue. They expressed interest in trying a 5% concentration if it becomes available at a reasonable price.

The user shared progress pictures after using topical finasteride, minoxidil, and tretinoin for about 9 months, along with weekly microneedling, cold showers, and a diet free of processed foods. They reported no side effects.

The conversation discusses the timing of applying Minoxidil and finasteride after microneedling. Opinions vary, with some suggesting immediate application and others recommending waiting to avoid skin irritation.

The conversation discusses using minoxidil and finasteride for hair loss, with concerns about absorption and considering adding tretinoin for better results. Microneedling is suggested as a method to improve absorption, with varying depths and frequencies recommended.

A 42-year-old is using dutasteride, oral and topical minoxidil, ketoconazole, and a dermaroller for hair loss, with noticeable progress after six months. They are questioning if further gains are possible and considering stopping the dermaroller, as advised that future improvements may only involve hair thickening.

Clascoterone 5% topical solution shows promise for treating male-pattern hair loss by blocking DHT at the follicle without systemic absorption, potentially offering fewer side effects than oral treatments like finasteride. While results are promising, long-term safety and effectiveness need further study, and it may serve as a starting point for developing more effective treatments.

The user is frustrated with dermatologists who dismiss Minoxidil and finasteride as unsafe, instead recommending mustard oil, PRP, zinc supplements, and hair products. The user feels these suggestions are ineffective and is considering starting Minoxidil and finasteride despite the dermatologists' advice.

33 y/o male used topical fin/min and dermaroll biweekly, resulting in increased hair density and significant regrowth. He got the solution from Hims and also used a DermaPen for microneedling.