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GlossaryDexamethasone Suppression Test

measures cortisol response to synthetic glucocorticoid dexamethasone

The Dexamethasone Suppression Test (DST) is a diagnostic procedure used to assess adrenal gland function by measuring how cortisol levels in the blood respond to an injection of dexamethasone, a synthetic glucocorticoid. It is commonly used to diagnose conditions like Cushing's syndrome, where the body produces too much cortisol.

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community Comparing the effect of T suppression and DHT suppression

in Transgender 52 upvotes 1 year ago

Trans women discuss using finasteride and dutasteride for hair loss and whether to continue after testosterone suppression. One user reduced dutasteride dosage after achieving undetectable testosterone levels.

community Dutesteride time at which maximum serum DHT is supressed?

in Finasteride/Dutasteride 5 upvotes 3 years ago

Maximum serum DHT suppression for finasteride occurs at 8 hours, while for dutasteride, it occurs within 1 to 2 weeks with daily dosing. Dutasteride mesotherapy will be followed by blood tests to check serum DHT changes.

community Hair loss - Blood work (High DHEAS)

in Research/Science 8 upvotes 4 years ago

A user has been taking finasteride for 5 months with no improvement in diffuse hair loss and suspects high levels of prolactin, cortisol, progesterone, and DHEAS, as well as iron, might be contributing to the issue. They are also taking vitamin D to address a deficiency.

community Betamethasone dipropionate 0.05 (sernivo spray)

in General 76 upvotes 1 year ago

A user was prescribed betamethasone dipropionate spray for a receding hairline, which caused skin peeling and depigmentation. They stopped using it and are considering alternatives like BPC-157/TB-500 for healing.

community 6th Month Checkpoint! There is progress (I think?)

in Progress Pictures 29 upvotes 1 year ago

The conversation discusses a user's six-month progress in treating hereditary hair loss using a regimen that includes minoxidil, finasteride, dutasteride, and other medications. Opinions vary on the effectiveness and logic of the treatment, with some users suggesting additional methods like microneedling.

community Research Backed Dutasteride Simulator (Serum/scalp DHT included for all doses)

in Research 598 upvotes 1 year ago

A Dutasteride Simulator predicts serum dutasteride, serum DHT, and scalp DHT levels using models from research papers. It simulates various dosing schedules to determine steady-state effects and visualizes outcomes, including hair growth-related scalp DHT suppression.

community Comparing the effect of T suppression and DHT suppression

in Transgender 89 upvotes 1 year ago

The conversation discusses the use of 5-alpha-reductase inhibitors like finasteride and dutasteride for hair loss in transgender women, particularly in relation to testosterone suppression. The original poster has been using dutasteride and is considering stopping it due to undetectable testosterone levels.

community Estradiol blood test on fin. Doctor dont want to give me the test.

in Finasteride/Dutasteride 10 upvotes 2 years ago

The user has been taking 0.5 finasteride for 10 months and wants to repeat blood tests, including estradiol. However, their doctor is reluctant to test estradiol, arguing it's typically low in men, and the user is considering seeking a second opinion.

community Dht bloodwork results. Currently on topical fin for 4 months.

in Chat 2 upvotes 2 years ago

JeremySoCa's DHT level was 29 ng/dl, considered low, and Estradiol was 26.1 pg/dl within the normal range. They are using topical finasteride for hair loss and had a thyroidectomy due to Graves' disease.

community Serum DHT test Germany (Dutasteride mesotherapy)

in Research/Science 1 upvotes 1 year ago

The user is starting dutasteride mesotherapy and seeks information on checking serum DHT levels in Germany. They previously tried finasteride but experienced unpleasant side effects.

community Research Backed Dutasteride Simulator (Serum/Scalp DHT included for all doses)

in Finasteride/Dutasteride 116 upvotes 1 year ago

A dutasteride simulator predicts that daily 0.5 mg dosing results in higher DHT suppression compared to less frequent dosing. Twice-weekly dutasteride may be as effective as finasteride 5 mg, providing a balance between efficacy and ease of use.

community Female AGA - Low Cortisol/Low DHEA

in Female 7 upvotes 3 years ago

Female (37) experiencing hair loss for 5 years, tried max dose of spiro and oral + topical minox without success. Discovered low cortisol and low DHEA levels, seeking functional medicine practitioner for help.

community Low cortisol it is due the fin

in Finasteride/Dutasteride 7 upvotes 9 months ago

The user has been taking 1mg finasteride daily for a year with no improvement in hair loss and reports low cortisol levels, sleep issues, and anxiety changes. The conversation includes discussions on the potential effects of finasteride on cortisol and neurosteroids, with suggestions to consult a doctor and consider other factors.

community Can I use topical steroid along finasteride to reduce scalp inflammation and hairloss?

in Finasteride 5 upvotes 7 years ago

The user asks if finasteride can be used with the topical steroid betamethasone dipropionate to reduce hair loss and scalp inflammation. The discussion revolves around combining these treatments for better results.

community The rate of Scalp DHT suppression does not reduce hair miniaturization at the same rate

in Finasteride/Dutasteride 46 upvotes 7 months ago

Reducing scalp DHT doesn't directly correlate with preventing hair miniaturization, as different follicles have varying sensitivity levels. Dutasteride at 0.5 mg and 2.5 mg shows minimal visual difference in hair regrowth, with side effects being a consideration for higher doses.

community DIM + Calcium d-Glucarate (lowering Estrogen)

in Chat 4 upvotes 2 years ago

Using DIM and Calcium D-Glucarate to reduce finasteride side effects. Discussion includes dosage, brand, and product effectiveness.

community DHEA, the culprit behind DUPA ? Read this!

in Research/Science 18 upvotes 2 years ago

High DHEA levels may contribute to hair loss by increasing DHT in hair follicles, potentially explaining why finasteride is ineffective for some. Treatments like high-dose dutasteride and RU58841 are suggested, but the underlying cause, such as adrenal issues, should be investigated.

community Why is scalp DHT suppression lower than systemic?

in Finasteride/Dutasteride 11 upvotes 7 months ago

Dutasteride reduces DHT more effectively in hair follicles than finasteride, but some individuals still experience hair loss despite treatment. Combining oral and topical finasteride may improve results, and some users experiment with topical dutasteride despite uncertainties about its absorption.

community Serum DHT data wanted for insights into dutasteride efficacy. Please get in touch!

in General 132 upvotes 1 year ago

The conversation is about gathering serum DHT data from individuals taking dutasteride to investigate its efficacy, especially in cases with unexpectedly low DHT reduction. The aim is to explore potential genetic factors affecting drug metabolism.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 6 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community I'm a tressless woman who's ready to call it quits.

in Female 12 upvotes 6 years ago

A woman who is considering giving up on her hair loss journey after trying minoxidil and spironolactone, but other posters offer words of encouragement and suggest the use of wigs.

community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

in Update 39 upvotes 7 years ago

The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

community for those who had high levels of testo and estradiol after start fin/dut: did it comeback to baseline or normal levels?

in Finasteride/Dutasteride 8 upvotes 1 year ago

A user experienced increased testosterone and estradiol levels after starting finasteride/dutasteride and is asking if these levels will return to normal over time. The conversation focuses on whether these changes are temporary.

community Trestolone (MENT) as a nuclear treatment

in Treatment 99 upvotes 3 years ago

Experimenting with trestolone as a treatment for hair loss in an attempt to avoid DHT-related treatments such as finasteride and dutasteride, and discussing the potential effects of its receptor selectivity on the androgen receptors in the scalp.

community If my T was suppressed due to taking HRT, why would dutasteride still be causing a SHED?

in Transgender 13 upvotes 8 months ago

Dutasteride can cause hair shedding even with suppressed testosterone levels due to previous damage from DHT. Hair shedding is often a sign of damaged hair being replaced by healthier growth.

community Dim: high estradiol levels what to do

in Chat 8 upvotes 1 year ago

A user is experiencing facial bloating from low-dose topical finasteride due to high estradiol levels and is seeking advice on using DIM to manage this issue, including dosage and brand recommendations.

community Result of my cortisol, prolactin, testosterone, ACTH blood test,

in Update 5 months ago

OP is using 5% minoxidil and a foligain supplement for hair loss, with blood test results showing high cortisol levels. OP is considering starting finasteride, while another user shares their experience with finasteride and hair loss challenges due to malabsorption issues.

community Estradiol mesotherapy / idea feedback

in Female 7 upvotes 1 year ago

The conversation discusses using estradiol mesotherapy to replicate hormone replacement therapy results while minimizing systemic exposure. It also covers the use of Spironolactone cream, which reportedly has no systemic side effects, and the potential risks of using bicalutamide and Spironolactone in men.

community [HELP!] TOPICAL FINASTERIDE BLOOD TEST DONE! [0.025% vs 0.015%]

in Finasteride/Dutasteride 9 upvotes 2 years ago

User experienced good results with topical finasteride, noting reduced DHT and increased testosterone. They plan to revert to a lower dosage after observing slight libido reduction.

community What hormones/vitamins should I test for?

in General 51 upvotes 9 months ago

The user plans to test for DHT, total testosterone, free testosterone, E2, SHBG, and prolactin while supplementing with vitamin D and monitoring ferritin levels. They are experiencing hairline thinning and are seeking advice on whether their approach is excessive or lacking.