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GlossaryDimethyl Sulfoxide

organic solvent that penetrates biological membranes effectively

Dimethyl Sulfoxide (DMSO) is an organic compound known for its ability to penetrate biological membranes, making it useful as a solvent in pharmaceutical and medical applications. It has anti-inflammatory and analgesic properties and is sometimes used topically to relieve pain and inflammation, although its use is regulated due to potential side effects.

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community Anyone is going to test if verteporfin work in the upper area or demaroller + verteporfin?

in Technology 17 upvotes 2 years ago

The conversation is about the interest in testing verteporfin, potentially with a dermaroller, for hair loss treatment. There is frustration over the lack of group buys for promising treatments compared to past efforts with less evidence.

community There must be many of you by now who have stuck with a microneedling program, how'd you make out?

in Technology 14 upvotes 9 months ago

Microneedling with finasteride, minoxidil, DMSO, and black seed oil shows mixed hair regrowth results. There are concerns about DMSO's safety and effectiveness.

community Forgotten 'Total Revival' Stack

in Research/Science 42 upvotes 1 year ago

Cyclosporine A is discussed as a powerful hair growth stimulant, potentially more effective than minoxidil, but concerns about safety and side effects, including cancer risk, limit its use. The conversation highlights the need for further research and experimentation with topical application, despite its risks.

community Castor oil without using penetration enhancer after microneedling?

in Question 7 upvotes 8 years ago

The conversation is about whether castor oil can be effectively used alone after microneedling without a penetration enhancer like DMSO or ethanol. The user believes microneedling-induced wounds might be enough for absorption.

community Topical finasteride with DMSO? Not sure what to do

in Finasteride/Dutasteride 4 upvotes 3 years ago

A user is considering using a 0.025% topical finasteride solution with DMSO to enhance absorption but is unsure about its effectiveness and safety. Other users express concerns about DMSO's properties and potential effects on the scalp.

community Trichosol, polyethylene glycol, and DMSO

in Minoxidil 3 upvotes 2 years ago

The user experiences irritation from alcohols in minoxidil and is considering alternatives like trichosol mixed with polyethylene glycol or DMSO. They seek advice on the best nonirritating option.

community Topical Minoxidil foam + Finasteride

in Finasteride/Dutasteride 1 upvotes 1 year ago

The conversation discusses using minoxidil foam as a solvent for topical finasteride. Ingredients of minoxidil foam include butane, cetyl alcohol, glycerin, and purified water.

community questions regarding topical finasteride

in Finasteride 4 upvotes 6 years ago

The conversation discusses the potential effectiveness and risks of using topical finasteride for hair loss, with considerations about using DMSO as a vehicle for application. Concerns are raised about DMSO's safety, absorption issues, and the systemic effects of topical finasteride.

community Solvent for topical fin with low absorption

in Product 2 upvotes 1 year ago

The conversation is about using distilled water as a solvent for topical finasteride to reduce systemic absorption. The user is considering avoiding ethanol and propylene glycol to achieve this.

community Homemade finasteride foam similar to minoxidil foam

in Product 1 year ago

A user is seeking advice on creating a homemade finasteride foam similar to over-the-counter Minoxidil foam, due to issues with glycerin and propylene glycol in their current solutions. They are considering using a mixture of ethanol/alcohol and water for the foam.

community Diluting DIY topical finasteride

in Finasteride/Dutasteride 2 upvotes 8 months ago

A user is discussing making a DIY topical finasteride solution using ingredients like water, alcohol, propylene glycol, ethanol, and glycerin, and is concerned about the stability of the mixture. Other users suggest that the solution will work and discuss the importance of propylene glycol for drug dissolution and factors like temperature and light affecting finasteride stability.

community What to mix castrol oil with for better absorption?

2 upvotes 10 years ago

The conversation is about improving castor oil absorption for hair loss treatment. The user tried ethanol and sweet almond oil mixtures and plans to try DMSO next.

community Haircafe video on Min Sulfate, thoughts?

in Research/Science 101 upvotes 6 months ago

Minoxidil sulfate is considered for those unresponsive to regular minoxidil, with some trying a 10% formulation from Folligenz. Concerns exist about the product's stability and transparency, but some users report positive initial results.

community Can I use minox with isopropyl alcohol to create topical spiro?

in Research/Science 3 upvotes 10 months ago

Minoxidil can be used with isopropyl alcohol to create topical spironolactone. Spironolactone may dissolve better in ethanol or propylene glycol.

community Making topical finasteride with ethanol + propylene glycol vs mixing it with topical minoxidil

in Finasteride/Dutasteride 2 upvotes 5 months ago

The conversation discusses two methods for making topical finasteride: using ethanol and propylene glycol or mixing it with topical minoxidil. The focus is on solubility and absorption, with a suggestion to crush pills finely and possibly mix with minoxidil at a slightly elevated temperature.

community Is my math correct? Mixing topical finasteride with stemoxydine to dilute the solution

in Finasteride/Dutasteride 6 upvotes 3 years ago

The post discusses diluting 100ml of 0.1% topical finasteride with 90ml of stemoxydine to create a 0.05% solution, aiming for a longer-lasting and potentially less side-effect-prone treatment. The user seeks feedback on this idea.

community RU-58841 appears to not be soluble in common Minoxidil solutions

in Research/Science 7 upvotes 7 months ago

RU-58841 does not dissolve well in common Minoxidil solutions due to water content, requiring a 70/30 ethanol/propylene glycol mix. Users report using separate solutions for RU-58841 and finasteride/Minoxidil for better results.

community Making topical finasteride solution

in Finasteride/Dutasteride 1 upvotes 2 years ago

The user has been mixing finasteride with stemoxydine for hair loss and is considering switching to a less expensive product with a different ingredient list. They are questioning if the new product's higher water content compared to alcohol will affect the finasteride's solubility.

community What to dilute Finasteride with?

in Treatments 65 upvotes 10 months ago

Diluting finasteride in a Hims spray can be done using ethanol or propylene glycol to maintain the desired concentration without increasing minoxidil levels. This approach ensures the finasteride concentration is reduced to 0.025% without affecting the minoxidil strength.

community Preparing Topical Finasteride with Stemoxydine

in Finasteride/Dutasteride 10 upvotes 5 years ago

Creating a topical solution combining finasteride and stemoxydine to treat hair loss, and the discussion of whether 15mg of finasteride would be sufficient for 60ml solvent.

community Minoxidil hack PSA for you all

in Treatment 59 upvotes 1 year ago

Switching from liquid to foam Minoxidil to avoid scalp irritation, with a method to melt the foam for easier application. Users discuss alternatives and personal experiences with Minoxidil, including issues with propylene glycol and different application methods.

community thoughts on this approach to topical fin that I want to try?

in Finasteride/Dutasteride 2 upvotes 1 year ago

User plans to switch from oral to .005% topical finasteride, using a solvent from minoxidilmax and later Essengen-F. They will monitor DHT levels and seek advice on solvents and sleep caps.

community Effects of 2% vs 5% min for sebderm

in Minoxidil 1 upvotes 2 years ago

Switching from 2% liquid minoxidil to 5% foam minoxidil reduced scalp irritation but increased eyebrow flakiness and thinning. The user speculates that propylene glycol in the liquid formulation might have been protecting against seborrheic dermatitis while causing contact dermatitis.

community Topical Finasteride with rogain foam as solvent

in Finasteride/Dutasteride 1 upvotes 4 years ago

The conversation discusses using Rogain foam as a solvent for topical finasteride due to an allergy to propylene glycol. The foam's ingredients, including alcohol SD 40B, are considered suitable for dissolving finasteride for easier application without skin irritation.

community What’s the highest minox % you home brewed ?

in Minoxidil 2 upvotes 1 year ago

A user discusses their experience with dissolving high concentrations of minoxidil in various ethanol/PG ratios and mentions difficulties with combining it with RU58841. They note that a 5% minoxidil solution remains stable, while higher concentrations tend to precipitate.

community Je peux utiliser ce produit seul comme solvant pour dilluer mon finasteride ?

in Finasteride/Dutasteride 1 month ago

OP asked if a product from Amazon is sufficient to dilute finasteride. A user advised against using propylene glycol alone, suggesting a pre-made solution instead.

community MSM [Methylsulfonylmethane] ??

in Treatment 5 upvotes 2 years ago

Methylsulfonylmethane (MSM) is not a treatment for male pattern baldness but can accelerate hair growth and thicken miniaturized hairs, with the side effect of increased hair growth all over the body. The user asks others to share their experiences with MSM.

community For pg free minoxidil, why not use propanediol instead of glycerin?

in Minoxidil 2 upvotes 1 week ago

The conversation discusses using propanediol as an alternative to glycerin in PG-free minoxidil for better absorption. The user also plans to try nanoxidil, which may absorb more easily due to its smaller molecule size.

community How do you guys dilute topical finasterid?

in Product 2 upvotes 3 years ago

Mixing topical finasteride with essengen f and stemoxydine creates 0.25mg dose in 2ml. Minoxidil max suggests mixing 8.5ml essengen f with 60ml solvent for 0.25mg dose in 1ml.

community Diluting 0.05% topical finasteride serum/oil

in Finasteride/Dutasteride 1 upvotes 2 years ago

The user wants to reduce their dose of topical finasteride to 0.1-0.2mg and is considering mixing 0.2ml of their current finasteride + minoxidil serum with 0.8ml of a minoxidil-only serum for better scalp coverage. They are asking for advice on whether this method is effective or if there's a better way to dilute the finasteride solution.