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Pelage Pharmaceuticals' PP405, a new hair loss treatment, was recognized by Time Magazine as one of the best inventions of 2025. The conversation expresses optimism about the recognition of this in-development treatment.

The user shared a 10-month hair loss treatment update using finasteride, minoxidil, derma stamping, red light therapy, and keto shampoo, reporting improved styling ability but a stubborn frontal hairline. The user experienced lower libido as a side effect of finasteride.

Hair loss discussion includes microneedling and optimal needle lengths. Users suggest doing treatments at night for better healing.

A 23-year-old shared progress pictures after 9 months of using dutasteride and 8 months of applying minoxidil once daily due to scalp psoriasis. Users complimented the results and discussed lighting effects on hair appearance.

The user reported significant hair regrowth after 4 months using Dutasteride, oral and topical Minoxidil, Nizoral shampoo, and dermastamping. They experienced minor side effects but noted consistent progress and regrowth, especially at the hairline and temples.

User started using Pantostin Alfatradiol after watching haircafe on YouTube and noticed thicker hair. They wonder why it's not more popular, as it's a 5α-reductase inhibitor with a different mechanism than minoxidil.

The conversation discusses using tretinoin with topical minoxidil for hair regrowth, despite previous non-response to minoxidil and concerns about oral minoxidil's heart risks. The user is also on dutasteride and is considering a hair transplant if other options fail.

The user has experienced hair regrowth using finasteride, minoxidil, dermarolling, and nizoral shampoo, but is considering a hair transplant due to advanced hair loss. Others suggest checking the donor area and considering a reputable surgeon for a potential transplant.

The conversation discusses the effectiveness and side effects of DUT mesotherapy for hair loss. Users are seeking evidence and pictures of successful treatments.

The user shared progress in hair regrowth using finasteride, minoxidil, a dermaroller, hair/nails gummies, and rosemary oil. They expressed gratitude for the support from the group and relief about their appearance for an upcoming wedding.

A regimen for hair loss, which includes using Nizoral shampoo twice daily, Minoxidil foam from the can, 5mg of Propecia crushed and snorted on weekends, and dermastamping directly to the head of the penis. Replies discuss potential sides and other treatments, as well as the idea that confidence is more attractive than hair.

A user suggests that a .25% topical finasteride solution could reduce scalp DHT levels without affecting bloodstream DHT levels, potentially avoiding sexual side effects. They question why a 2.5% solution was chosen and if a custom .25% solution can be ordered.

User noticed beard and sideburn hair loss, and thinning eyebrows, diagnosed with alopecia barbae and male pattern baldness, and prescribed Desonide cream. User seeks feedback on Desonide cream.

21-year-old female experiencing hair loss and visible scalp seeks advice on PRP effectiveness. Currently taking spironolactone and krimson for high androgens, unsure if PRP can be done with these medications.

OP is using 0.5mg dutasteride, 5mg biotin, 5% topical minoxidil twice daily, and dermarolling 1-2 times a week for hair loss. OP reports no side effects and is happy with the progress after 5 months.

The user seeks alternatives to Propylene Glycol (PG) for delivering topical finasteride due to scalp irritation. They consider using Propanediol 1,3 and ask for other suggestions.

The conversation is about using DIY deoxyribose topical and botox injections for hair loss. The user is experimenting with these treatments and believes the science is strong.

A user is using a mix of 15ml coconut oil and 6 drops of rosemary oil applied to the scalp three times a week for an hour before washing, seeking natural hair growth methods before considering medications. The user asks if this technique is effective and requests respectful advice.

The user is observing potential hair regrowth at day 46 using 1mg oral finasteride, 2.5mg oral minoxidil, 5% topical minoxidil, biotin, vitamin D, fish oil, and weekly dermal rolling. They are optimistic about the results despite skepticism from others.

A 55-year-old user shared progress pictures after 5 months of using dutasteride 6 times a week and minoxidil 2.5 mg daily, reporting hair regrowth and some side effects like mild erectile dysfunction and foot swelling. The user attributes recent hair loss to creatine and notes improvement after adjusting the treatment regimen.

The user shared a 3-year hair restoration update using 0.5mg dutasteride daily, 5% minoxidil foam twice daily, a 1.5mm derma roller twice a month, and Nizoral shampoo. They reported significant improvement and maintenance of hair, with minimal side effects, and are satisfied with the results at age 40.

A user's successful 4-month hair growth progress using Hims spray with 6% Minoxidil, 0.3% Finasteride, and a .25mm dermaroller twice a week. The user applies the spray once a day and has not experienced any side effects.

User sshamu's progress pictures of 4 months using minoxidil foam and 1MM dermarolling for hair loss, which resulted in impressive results. There is also discussion about how often to use the treatments, as well as potential side effects of finasteride.

The user reports hair regrowth after 15 weeks using oral finasteride, topical minoxidil, oral pumpkin seed oil, and ketoconazole shampoo. Images show progress before and after treatment.

The user shared their 5-month hair regrowth progress using oral finasteride daily, topical minoxidil twice daily, derma stamping weekly, castor oil weekly, and the Nioxin system kit. Replies praised the results and inquired about the timeline and side effects.

The user shared their 4-month hair loss progress, noting initial hair loss followed by improvement. They used a dermaroller twice a week with varying needle sizes.

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

The user is considering using topical finasteride for thinning hair around the middle part, vertex, and crown, and is unsure if the whole scalp is thinning. Another user suggests oral finasteride is more effective than topical, and recommends consulting a dermatologist for proper treatment.

The user found success in treating hair loss by using a derm stamp with castor oil, vitamin E oil, and rosemary oil, alongside finasteride. The derm stamp, used every other day at 0.5 mm, significantly improved hair thickness and growth.

Verteporfin shows promise in donor hair regeneration after 84 days. Combining Finasteride, Minoxidil, and Pyrilutamide with unlimited hair transplants is seen as a potential near-cure for hair loss.