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      community Bile Acid-Mediated DHT Dysregulation Hypothesis

      in Research/Science  13 upvotes 1 year ago
      Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

      community Clascoterone 12 months phase 3 result out

      in Treatment  46 upvotes 3 months ago
      Clascoterone is promising for hair loss, showing 24.5% improvement in satisfaction compared to placebo. Users consider it an alternative to finasteride, with concerns about absorption and side effects.
      21M on Finasteride & Topical Minoxidil: Is My Frontal Thinning AGA or TE?

      community 21M on Finasteride & Topical Minoxidil: Is My Frontal Thinning AGA or TE?

      in General  43 upvotes 11 months ago
      A 21-year-old is experiencing hair thinning and is using oral finasteride and topical minoxidil, considering adding oral minoxidil. They are unsure if the condition is androgenetic alopecia (AGA) or telogen effluvium (TE) and are advised to continue treatments and get a blood test.

      community Anyone here used spirolactone/cyproterone acetate/bicalutamide?

      in Chat  4 upvotes 11 months ago
      The conversation discusses the use of spironolactone, cyproterone acetate, and bicalutamide for hair loss, with concerns about side effects like gynecomastia and depression. Topical spironolactone is considered safe for men and effective when combined with regular treatments.

      community Best available SARD right now?

      in Treatment  3 upvotes 3 months ago
      The user is considering RU58841 and has been using dutasteride since age 17. They are seeking affordable SARD options, mentioning ASC-J9, GT20029, and AH001.

      community Hair transplanting pubes and ass hairs: Pros and cons

      in Satire  304 upvotes 11 months ago
      Transplanting pubic and butt hair to the head is discussed humorously, highlighting pros like DHT resistance and cons like poor blending and appearance. Users joke about using treatments like Minoxidil, Finasteride, and RU58841 on unconventional donor areas.

      community KX-826 alone to stop hairloss???

      in Treatment  13 upvotes 9 months ago
      A 28-year-old male experiencing early male pattern baldness is considering using Pyrilutamide (KX-826) as an alternative to finasteride due to side effects. He seeks to maintain his current hair without regrowth and is concerned about potential side effects like reduced libido.

      community Breezula phase 3 results said to be released next month

      in Product  28 upvotes 1 year ago
      Breezula's phase 3 results are expected soon, with discussions on the effectiveness of androgen receptor antagonists like spironolactone and the potential of GT20029. Users express skepticism about new treatments and discuss the complexities of male pattern baldness, often relying on finasteride despite its side effects.

      community Hair transplant 4 month update 3900 grafts and

      in Progress Pictures  442 upvotes 8 months ago
      A 24-year-old shared a 4-month update on their hair transplant of 3900 grafts done by Dr. Serkan Aygin in Turkey, costing 3100 euros. They have been using topical minoxidil at night and 1mg of finasteride daily for about a year and a half before the transplant.

      community KX826 New Phase 3 Trial In China for 2025: 1.0% concentration

      in Research/Science  60 upvotes 1 year ago
      KX-826 is undergoing Phase III trials in China as a potential treatment for male pattern baldness, with some users considering it as an alternative or addition to finasteride and dutasteride. Opinions on its effectiveness vary, with some users reporting positive results and others finding it expensive and ineffective.

      community Finasteride and male phenotypes

       5 upvotes 11 years ago
      Finasteride's effectiveness and side effects may vary based on male phenotypes, with some users noting differences in response related to body and facial hair characteristics. Some users report success with lower doses, while others experience side effects, suggesting individual variability in response to the treatment.

      community Dutasteride and Sperm Volume concern

      in Finasteride/Dutasteride  5 upvotes 3 months ago
      Dutasteride can significantly reduce sperm volume, with some users experiencing up to a 90% decrease. While some users report adaptation over time, others suggest switching to finasteride if side effects are too severe.

      community Scalp Biopsy Results - Almost 2 Years Dutasteride, Still Worsening

      in Update  24 upvotes 11 months ago
      Dutasteride and finasteride are not effectively stopping hair loss for some users, despite long-term use. Some are considering or using RU58841, pyrilutamide, and other treatments like microneedling, while also managing seborrheic dermatitis with diet and topical solutions.

      community Can a HT fix a severe case of diffuse thinning scalp?

      in Chat  1 upvotes 2 years ago
      The user has severe diffuse thinning on the scalp and is using finasteride, topical minoxidil, dermarolling, tretinoin, and Nizoral without satisfactory results. They are considering a hair transplant but are concerned about the cost and the number of grafts needed.

      community I posted once before in this sub about my struggle to get a script for a DHT blocker other than Spironolactone, here’s visual evidence that I am in fact biologically female. How bad is it, lads

      in Female  6 upvotes 3 years ago
      The conversation is about a female's difficulty in obtaining a prescription for a DHT blocker other than Spironolactone for hair loss. She is seeking advice on the severity of her condition and discussing specific treatments like Minoxidil, Finasteride, and RU58841.

      community Temple regrowth, 5 months on fin + min

      in Progress Pictures  233 upvotes 5 months ago
      A trans man shared his 5-month progress using finasteride and minoxidil for temple regrowth, noting slow but steady results. Despite some negative comments, he received support and encouragement from others, with advice to start treatment early for best results.

      community Spain or turkey? Where to source fin

      in Finasteride/Dutasteride  6 upvotes 4 months ago
      A user is seeking advice on sourcing finasteride from Spain or Turkey, considering cost and prescription requirements. In Turkey, Proscar 5 mg is available without a prescription for about $5 for 28 tablets.

      community Mesotherapy dutasteride photos before & after

      in Progress Pictures  5 upvotes 4 years ago
      The post discusses the use of mesotherapy with dutasteride for hair loss treatment, showing before and after photos. The conversation includes mentions of Minoxidil, finasteride, and RU58841 as other treatments.

      community 5ARI (dutasteride) Associated with Adverse Metabolic Effects

       22 upvotes 8 years ago
      Dutasteride is associated with increased blood glucose, HbA1c, LDL cholesterol, and liver enzyme activity, potentially leading to diabetes, NAFLD, and liver metabolism changes. The conversation highlights concerns about these adverse effects and calls for more studies, including on finasteride.