Scalp inflammation can cause hair thinning and may be related to diet, infections, or conditions like psoriasis. Treatments suggested include using Nizoral shampoo and checking vitamin levels.
KX-826 Phase II results show that a 0.5% concentration performs better than 1% for treating male pattern baldness. Concerns about receptor upregulation from long-term DHT antagonism were mentioned.
A 28-year-old male is experiencing hair loss despite using topical and oral Minoxidil, oral Finasteride, and recently switching to oral Dutasteride. He is considering whether to return to topical Dutasteride or add Dutasteride mesotherapy to better target scalp DHT.
Fluridil may decrease the number of androgen receptors in hair follicles by up to 95%. This suggests a different action mechanism from other non-steroidal antiandrogens like RU58841, indicating they might be used together.
User shared 6-month progress using topical finasteride, biotin, and occasional dermarolling, reporting no side effects except possible depression. Replies praised the results and shared personal experiences with finasteride.
The user has been using liposomal topical finasteride since late 2022, progressively increasing the dose, but DHT serum levels remain largely unchanged. Despite using finasteride, minoxidil, microneedling, and ketoconazole, hair condition has neither improved nor worsened.
The conversation is about finding a source for sterile dutasteride for mesotherapy to avoid side effects from oral 5AR blockers. The user is currently using microneedling and 0.01% topical dutasteride and plans to use transplants.
A 30-year-old male is using a regimen of dutasteride, minoxidil, ketoconazole shampoo, tretinoin cream, and microneedling for hair regrowth. He reports no side effects and has noticed visual improvement after one month.
Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.