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GlossaryEpigallocatechin Gallate

powerful antioxidant in green tea with potential hair growth benefits

Epigallocatechin Gallate (EGCG) is a powerful antioxidant found predominantly in green tea. It has been studied for its potential health benefits, including anti-inflammatory, anti-cancer, and heart-protective effects. In the context of hair and alopecia, EGCG has shown promise in promoting hair growth and reducing hair loss by inhibiting the activity of hormones and enzymes that contribute to hair follicle shrinkage.

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community Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles - PubMed

in Research/Science 15 upvotes 3 years ago

The conversation discusses hair regrowth using dissolvable microneedles loaded with rapamycin and epigallocatechin gallate nanoparticles. Specific treatments mentioned include Minoxidil, finasteride, and RU58841.

community This serum outperformed Minoxidil in a recent study. Please debunk

23 upvotes 6 years ago

A topical solution called "Multi-Peptide Serum for Hair Density" by The Ordinary Company, which contains several ingredients that are used in alternatives to Minoxidil and was found to have better results than 5% Minoxidil in a study. People who have tried it shared their experiences with the serum as well.

community Natural Remedies: Polyphenols and Hair Loss

20 upvotes 6 years ago

Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.

community Creating Custom Topicals: A Guide (2025 Edition)

in Research/Science 27 upvotes 7 months ago

Creating custom topical treatments for hair loss using minoxidil, finasteride, and RU58841. It includes recipes and instructions for home preparation, focusing on cost savings and customization.

community Gartanin Degrades dht receptor found in mangosteen fruit. Gonna buy the raw powder mix it with castor oil and filter out the rest. And apply topically.

5 upvotes 8 years ago

The conversation discusses using gartanin from mangosteen mixed with castor oil to degrade the androgen receptor for hair loss treatment. Alternatives like setipiprant, minoxidil, and dermastamping are also mentioned, with concerns about cost and potential side effects.

community Theaflavin (Black Tea Extract) reduce DHT, androgen receptor activity and estrogen

in Research/Science 8 upvotes 2 years ago

Theaflavin, a black tea extract, may inhibit DHT and androgen receptor activity, but its effectiveness for hair loss is debated. Users report no significant improvement with theaflavin, while some find beta sitosterol helpful.

community STUDY: NAD⁺ Precursors + EGCG Increased Hair Density

in Research/Science 8 upvotes 2 months ago

NAD⁺ precursors and EGCG may increase hair density, but users report mixed results with no significant hair gains. Some users suggest combining these with finasteride or dutasteride for better results.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 739 upvotes 3 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Ginsenoside enriched formulation

in Treatment 1 year ago

Panax ginseng, specifically a ginsenoside-enriched formulation, is suggested as a potential hair growth treatment alongside finasteride and minoxidil. The user is considering trying panax ginseng despite limited availability and evidence.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 133 upvotes 2 years ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community Procyanidin B2 Supplement

in Research/Science 13 upvotes 5 years ago

User seeks Procyanidin B2 supplement source and asks for dosage comparison. Another user requests study details and apple type importance.

community Caffeine + Dimethylglycine (DMG) Shampoo research

in Research/Science 6 upvotes 1 year ago

A user discusses the potential of caffeine and DMG in shampoo for treating hair loss, citing a pending patent and personal plans to test it. They find it more convenient than using minoxidil, tretinoin, and microneedling.

community According to this study, drinking green tea might make things worse?

in Research/Science 5 upvotes 2 years ago

The conversation discusses whether drinking green tea affects hair loss, with one user concerned it might increase DHT levels. The user is already using finasteride and wants to ensure green tea doesn't hinder progress.

community Any merit to this daily leave in foam? Saw P/Caffeine

in Treatment 2 upvotes 1 year ago

The conversation is about hair loss treatments. The user considers using a foam with Saw palmetto, caffeine, and EGCG, but another user suggests just using finasteride.

community My DHT-blocking protocol, I'm exited!

6 upvotes 6 years ago

The post discusses a hair loss treatment regimen using saw palmetto, pumpkin seed oil extract, EGCG (green tea) extract, grape seed oil extract, rosemary oil extract, and Zix. The user plans to use these DHT-blockers and 5AR inhibitors for six months and report the results.

community Patent for topical resveratrol and melatonin for AGA

4 upvotes 6 years ago

The conversation discusses a patent for using topical resveratrol and melatonin to treat androgenetic alopecia (AGA) and also mentions interest in topical sulforaphane as a treatment.

community RU58841 KB Solution vs PG + Ethanol

in Research/Science 6 upvotes 2 years ago

The conversation discusses the differences between KB solution and PG + Ethanol solution for RU58841 in treating hair loss. It compares the effectiveness and properties of these two solutions.

community An Uncontrolled Case Series Using a Botanically Derived, β-Cyclodextrin Inclusion Complex in Two Androgenetic Alopecia-Affected Male Subjects

in Research/Science 1 upvotes 5 years ago

The conversation discusses a botanically derived treatment for androgenetic alopecia using ingredients like saw palmetto, green tea, and evening primrose, showing impressive results over 270 days. Concerns include the study's uncontrolled nature and potential product motivation, with suggestions to enhance absorption through derma rolling.

community Helicobacter's concocted serum v1

6 upvotes 7 years ago

A custom-made serum based on double-blind studies for AGA, which includes natural ingredients such as rosemary oil, procyanidin B-2, saw palmetto extract, curcuma aeruginosa, pumpkin seed oil and castor oil. The user has updated their recipe to include apple poly procyanidin B-2 4% concentration and other ingredients before topping it off with Pura d'or serum.

community Anagenic is trying to compound Gt20029

in Treatment 56 upvotes 3 years ago

The conversation discusses concerns that Anagenic's version of GT20029 might not be as effective or safe as Kintor's, with comparisons to issues faced by pyrilutamide. The chemical structure of the drug has been published.

community GT20029. Kintor Pharma’s Product

in Research/Science 12 upvotes 3 years ago

The conversation discusses GT20029, a compound by Kintor Pharma that degrades androgen receptors and is in trials, with potential as a hair loss cure. Another promising treatment mentioned is an antibody that blocks prolactin and has shown positive results in macaques.

community Procapil - Has anyone heard of it?!

in Research/Science 1 upvotes 3 years ago

The conversation discusses Procapil, a treatment for hair loss containing Apigenin and Oleanolic acid. Users are sharing their experiences and asking if anyone has tried it.

community Ben Greenfield Podcast : CHK-Cu & C-60

in Research/Science 5 upvotes 4 years ago

CHK-Cu (copper peptide) and C-60 (branched carbon chain) are discussed as potentially more effective than minoxidil for hair regrowth. Some users are skeptical about the claim that DHT isn't the root cause of hair loss, and others are trying these products to see if they work.

community Looks like Kintor finished enrollment and dosing of phase 1 for gt20029 in China.

in Chat 25 upvotes 3 years ago

The conversation discusses the potential of a new hair loss treatment, GT20029, which targets androgen receptors in the scalp and is in phase 1 trials in China. Users express hope that this treatment will be more effective than current options like Minoxidil and Finasteride.

community Spanish dermatologist suggests sulforaphane for AGA

in Research/Science 13 upvotes 2 years ago

A Spanish dermatologist suggests sulforaphane for androgenetic alopecia (AGA) due to its potential to remove DHT metabolites, though high dosages are needed. A topical formulation might be possible.

community RU58841 carrier - PG/Ethanol vs KB solution?

in Treatment 2 upvotes 4 years ago

The conversation discusses the differences between PG/Ethanol and KB solutions for RU58841 application, focusing on potential scalp irritation. KB solution is suggested for those allergic to PG, though both contain ethanol which can dry the scalp.

community Saw this apparent study on twitter. Thoughts?

in Research/Science 6 upvotes 2 years ago

A mixture of MSM, kombucha, and black tea was applied topically for hair growth in mice. The conversation suggests skepticism about translating these results to humans.

community Green tea/ soy Isoflavones supplements for MPB

in Product 4 upvotes 5 years ago

Green tea extract and soy isoflavones may help with hair loss by inhibiting DHT and providing additional health benefits. Combining these with finasteride and possibly using nizoral shampoo could enhance effectiveness in managing hair loss.

community Ways to prevent hair from becoming grey or delaying the greying of hairs? (Have You Heard of Catalase!?)

in Research/Science 23 upvotes 1 year ago

Catalase is discussed as a potential treatment for delaying or reversing grey hair, but no reliable medicine currently exists. Other mentioned treatments include Imatinib, senolytics like Quercetin and Fisetin, He Shou Wu, Argan oil, and reishi mushroom extract, though their effectiveness varies.

community Ghk-cu + c60 + saw palmetto oil

in Treatment 5 upvotes 6 years ago

The conversation discusses using GHK-Cu, C60, and saw palmetto oil as treatments for hair loss. Specific treatments mentioned include Minoxidil (Min), Finasteride (Fin), and RU58841 (RU).