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The conversation is about the availability of hair loss treatments Breezula, SM04554, Follica FOL-004, and Follicum FOL-005 in Canada after FDA approval, including potential delays, loopholes for obtaining them, and insurance coverage.

A Phase II clinical trial for TDM-105795 has started recruiting in the US, and it might be a promising treatment for hair loss. Many hair loss drugs, including this one, originate from China.

The conversation is about obtaining alfatradiol in Canada, specifically in Quebec, and whether it requires a prescription or can be bought online. A user suggests ordering it from a specific website.

Fluridil degrades androgen receptors, which are prevalent in the scalp and other tissues. People with androgenetic alopecia (AGA) may have higher expression of these receptors and 5AR activity in affected scalp areas.

User reported initial hair regrowth with 0.25 mg finasteride taken four times a week, experiencing a second shedding phase, and no side effects. They also mentioned using RU58841 without success and plan to stop after a year.

User shared 18-month progress using 1 mg finasteride daily and varying doses of oral minoxidil. Minoxidil caused side effects managed with taurine, dandelion root, sauna, and collagen.

Finasteride use and its impact on male fertility. A user shared that they had no issues conceiving while using finasteride.

OP has been using alfatradiol and a mix of rosemary, peppermint, and jojoba oils for hair loss, with inconsistent dermapen sessions. They plan to add topical finasteride at 0.025% later.

A transwoman is struggling with hair loss despite using hormones, dutasteride, and Abiraterone, and is considering making her own treatments due to difficulty accessing them. She has also tried Eucapil and regularly uses Nizoral shampoo.

A 22-year-old male uses dutasteride, a serum with 10% minoxidil and 0.5% finasteride, and microneedling for diffuse androgenetic alopecia. Progress pictures show changes from July 2025 to February 2026.

Finasteride and Dutasteride do not cause depression or "Post Finasteride Syndrome," with concerns often linked to the nocebo effect and preexisting mental health issues. The EU is unlikely to ban these drugs, but access may become more restricted due to ongoing debates.

A 33-year-old male is experiencing thinning at the temples and hairline, with increased shedding over the past year. The user suspects androgenetic alopecia (AGA) despite AI suggesting a maturing hairline.

A 14-month update on a FUE hair transplant, and the effects of male pattern baldness. People discussed products such as Minoxidil, finasteride, Kerastase Chronologiste shampoo and care oil, and RU58841 to help treat hair loss.

The conversation discusses FUE hair transplant surgery, including questions about donor area recovery, success rates, precautions, hair growth rate, and the safety of PRP injections. It also inquires about using hairpieces post-surgery.

The conversation discusses using Dr. Fox Hair Growth Spray, which contains 0.3% finasteride, 5% minoxidil, and 0.01% tretinoin. It suggests that a compound pharmacy might offer a cheaper alternative.

A 34-year-old male started using 5% minoxidil foam for hair loss and experienced shedding, which is a normal part of the process. He is considering adding finasteride to his regimen but is concerned about potential side effects, particularly sexual performance issues.

FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

A doctor recommended Follivera as a minoxidil alternative, but users are skeptical, suggesting minoxidil, finasteride, or dutasteride for hair loss. Some users mention adenosine and piroctone olamine as potentially helpful ingredients.

The user has been using 1mg oral finasteride daily for four years, experiencing significant hair regrowth and increased testosterone levels without negative side effects. They advise patience and monitoring for side effects, noting that their hair continues to improve with this treatment.

The conversation humorously discusses hair loss treatments, including finasteride, dutasteride, minoxidil, and microneedling. The user shares progress and thanks the pharmaceutical industry, with comments on the effectiveness and side effects of these treatments.

The user experienced significant hair improvement after 15 months of treatment, using finasteride initially, then switching to dutasteride, and recently adding topical minoxidil. They credit their progress to dutasteride and support from Haircafe, a YouTuber.

TDM-105795 is a potential hair growth stimulant that works differently from minoxidil and could be used alongside it for enhanced growth. It completed phase 2 trials in 2024, with a medium to high chance of release in 2026, but lacks recent updates or phase 3 trial information.

The conversation discusses interest in participating in PP405 trials for hair loss treatment, with users expressing uncertainty about eligibility due to location. Participants are eager for updates and willing to pay for shipping if trials are limited to America.

A 23 year old user who has had success with finasteride and minoxidil, regaining their hair after losing it due to male pattern baldness. They also attribute part of the success to lifestyle changes such as eating better, exercising, sleeping well, and reducing smoking.

A 19-year-old concerned about long-term effects of 5AR inhibitors on physical appearance. They have used finasteride and plan to try dutasteride or RU58841; responses suggest improved skin, hair, and confidence.

People are discussing the anticipated release of PP405 phase 2a results, expected by the end of March, with some skepticism about its effectiveness. There is cautious optimism due to past experiences with similar treatments like Breezula, despite concerns about the lack of presentation at the AAD 2026 conference.

Finasteride's impact on fertility is discussed, with users sharing experiences of conceiving while on the medication. Concerns about long-term safety are also mentioned.

A user switched from Anageninc to Aesthetic Cosmetics for RU58841 and experienced increased shedding, questioning the product's authenticity. They seek advice on reliable sources for RU58841 in Australia.

Finasteride and minoxidil are discussed as hair loss treatments, with warnings about minoxidil's toxicity to cats. Suggestions include hair transplants, dutasteride, and humorous alternatives like red light therapy and rosemary oil.

The user stopped finasteride for family planning but plans to restart it and is considering dutasteride. Users discuss the safety of finasteride during family planning, with some sharing experiences of having healthy children while on the medication.