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      community Connection between finasteride and nafld?

      in Research/Science  4 upvotes 1 year ago
      Finasteride may affect liver function and cortisol levels, potentially linking it to non-alcoholic fatty liver disease (NAFLD). More research is needed to understand this connection fully.

      community Why Is No One Talking About Chromosome 20?

      in Chat  32 upvotes 7 months ago
      Some hair loss may be linked to chromosome 20, which isn't affected by DHT blockers like finasteride. Treatments like minoxidil, microneedling, and genetic testing are suggested, but their effectiveness for this type of hair loss is uncertain.

      community No, Finasteride as a treatment for MPB was not an "accident"

      in Research/Science  108 upvotes 4 years ago
      Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.

      community Hair Loss "a matter of survival" in South Korea

      in Research/Science  335 upvotes 3 months ago
      South Korea's president is advocating for hereditary hair loss to be covered by national health insurance due to its impact on mental health and daily functioning. The discussion highlights the societal pressure in South Korea regarding appearance and the potential benefits of treating hair loss to improve mental health.

      community Genomic Sequencing for Hair Loss

      in Research/Science  156 upvotes 3 weeks ago
      Hair loss treatments like Minoxidil, finasteride, and potential mRNA therapies are discussed. There is skepticism about targeting specific genes due to the complex genetic nature of hair loss.

      community Follow up appointment with Donovan.

      in Finasteride/Dutasteride  17 upvotes 2 years ago
      The user was diagnosed with DUPA and initially treated with finasteride, then switched to dutasteride which worsened their hair loss. They are now returning to finasteride and adding treatments including oral minoxidil, Proscar, Viviscal, pumpkin seed oil, LLLT, and Nizoral shampoo, hoping for hair regrowth.

      community Decades Update: age 23 to 25 and age 39 to 41

      in Progress Pictures  725 upvotes 1 year ago
      The user started using finasteride at age 23, stopped at 30 to start a family, and resumed at 39 with minoxidil, seeing positive results both times. They successfully had four children after stopping finasteride, noting changes in sperm quality and some side effects upon resuming the medication.

      community Information regarding Follicusan DP?

      in Product  3 upvotes 2 years ago
      Follicusan DP is discussed as a potential alternative to Minoxidil without side effects, but information is scarce. It is noted to be of German origin and details on its mechanism are limited.
      PP405 Identity Research

      community PP405 Identity Research

      in Research  292 upvotes 7 months ago
      PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

      community Been diagnosed with telogen effluvium and MPB

      in Chat  3 upvotes 7 months ago
      A 21-year-old male diagnosed with telogen effluvium and male pattern baldness started oral finasteride, which initially slowed hair loss and slightly thickened hair, but experienced increased shedding after surgery. The doctor recommended iron and vitamin D supplements, and the user is seeking additional advice.

      community Has anyone else seen this encouraging verteporfin case study?

      in Progress Pictures  34 upvotes 2 years ago
      The conversation discusses the potential use of verteporfin for hair loss treatment, with one user mentioning their surgeon's interest in trying it and another noting its research status and clinical use as a YAP inhibitor. Some users debate the market size, availability of generics, and the optimism in the hair loss community regarding new treatments.

      community Positive Hair Result in Patient using Tirzepatide

      in Research/Science  6 upvotes 1 year ago
      A 57-year-old man with male pattern hair loss and insulin resistance experienced hair regrowth and weight loss after using tirzepatide, without other hair treatments. Dysregulated glucose metabolism is linked to hair loss, with tirzepatide potentially improving hair density by normalizing insulin resistance.

      community Two Shedding Cycles? Telogen effluvium or not?

      in Question  4 upvotes 6 years ago
      The user experienced significant hair loss after extended fasting, initially thought to be Telogen Effluvium, but later suspected male pattern baldness. They tried finasteride briefly but stopped due to concerns about side effects, and are unsure if the hair loss is due to Telogen Effluvium or another cause.

      community Is this regrowth * finasteride only *

      in Is this regrowth?  114 upvotes 6 months ago
      The user is using finasteride 1.25mg three times a week for hair regrowth and reports no significant side effects except watery semen initially. They also use a local caffeine shampoo and are considering haircuts to improve appearance.

      community 17month progress. Topical fin and oral min

      in Progress Pictures  271 upvotes 5 months ago
      The user experienced hair regrowth using topical minoxidil and finasteride, and later added oral finasteride for maintenance. They reported no side effects and found a specific shampoo helpful for scalp issues.

      community Update on PP405 Trails - Pelage

      in Research/Science  14 upvotes 2 months ago
      The conversation discusses interest in participating in PP405 trials for hair loss treatment, with users expressing uncertainty about eligibility due to location. Participants are eager for updates and willing to pay for shipping if trials are limited to America.

      community Petition Alert: Let's Get PP405 Phase 3 Trials in Germany by 2026!

      in Research/Science  57 upvotes 9 months ago
      A user is advocating for Phase 3 trials of the hair loss treatment PP405 to be conducted in Germany, citing benefits like a diverse patient base and faster access for European patients. Despite skepticism about the petition's influence, the user believes it can demonstrate significant interest and potentially influence strategic decisions.