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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community 85 days Topical Min-Fin progress

      in Is this regrowth?  10 upvotes 6 months ago
      The user has been using a treatment of 0.1% topical finasteride, 5% minoxidil, dermastamping, and vitamin D3 supplements for 85 days and is seeing good progress. Other users note the effectiveness of topical finasteride despite it being less potent.

      community 1 year treatment - mixed feelings

      in Is this regrowth?  75 upvotes 8 months ago
      The user has been using finasteride for a year and recently started minoxidil, noticing reduced hair shedding but no significant regrowth. Suggestions include continuing the current regimen, adding micro-needling, and considering a hair transplant for more noticeable results.

      community 3-month progress with fin and min

      in Update  757 upvotes 1 year ago
      A 29-year-old male is experiencing positive hair regrowth after 3 months using oral finasteride (1mg) and topical minoxidil (1ml twice daily), despite side effects like scalp itchiness and dandruff. He plans to continue the treatment long-term and may switch to foam minoxidil to alleviate scalp issues.

      community Oral minox + dut

      in Research/Science  9 upvotes 5 years ago
      The conversation discusses hair loss treatments using oral minoxidil, oral dutasteride, and mesotherapy dutasteride, showing impressive 6-month results. The user wishes these treatments were available in the U.S.

      community What do we currently know about clascoterone?

      in Chat  5 upvotes 3 months ago
      Clascoterone is seen as a promising topical treatment for hair loss, similar to finasteride but without side effects, though concerns exist about its long-term effectiveness. Other treatments discussed include topical minoxidil, ketoconazole, microneedling, and oral options like dutasteride and minoxidil.

      community I got prescribed topical finasteride!

      in Finasteride/Dutasteride  20 upvotes 2 years ago
      The user was prescribed 0.3% topical finasteride with 5% minoxidil for use on the temples twice daily, while continuing minoxidil on the full scalp. Replies suggested using the treatment once daily and questioned the logic of treating only the temples, with one suggesting dilution for use across the entire scalp.

      community 6 months of Mexican Finasteride (1.25mg every other day). It’s working slow but steady.

      in Progress Pictures  282 upvotes 2 years ago
      A user shared a 6-month hair loss treatment routine including Mexican finasteride (1.25mg every other day), daily minoxidil, bi-weekly dermarolling, and ketoconazole shampoo twice a week, noting significant crown growth and some frontal hairline improvement with initial side effects that have since subsided. They are seeking advice to improve results, particularly at the frontal hairline, without resorting to a hair transplant.

      community Australian options for topical Fin and Min?

      in Treatment  7 upvotes 1 year ago
      An individual is seeking options for topical finasteride and minoxidil in Australia, considering products from Medicii Labs and exploring other suppliers. They plan to use a derma roller and caffeine + yerba mate hair wash alongside these treatments.

      community 5 month Progress (18m)

      in Progress Pictures  31 upvotes 5 years ago
      An 18-year-old shares a 5-month hair loss treatment progress using finasteride, minoxidil, microneedling, Nizoral, biotin, and fish oil. The user discusses the effectiveness of finasteride over time and considers continuing the regimen despite suggestions to simplify it.

      community Itchy and red scalp from treatment

      in General  53 upvotes 1 year ago
      The user experienced no regrowth after nine months on minoxidil and developed red bumps after starting finasteride. They also use Nizoral 2%, which helps slightly, but minoxidil causes intense itching.

      community Question regarding Topical finasteride solution

      in Finasteride/Dutasteride  3 upvotes 8 months ago
      A user is using a topical spray containing Finasteride 1% and Minoxidil 5% along with other ingredients like glycerin and aqua, questioning if these are effective carrier agents. They apply it once daily and use a separate 5% Minoxidil solution at night.

      community Topical Fin & Min, 5 Month Progress

      in Is this regrowth?  1181 upvotes 5 months ago
      Significant hair regrowth was achieved using a topical combination of 0.3% finasteride and 6% minoxidil, with weekly dermastamping and ketoconazole shampoo, without side effects. Others suggested additional treatments like red light therapy and PRP.

      community Trichotest Results: no Finasteride

      in Finasteride/Dutasteride  5 upvotes 4 years ago
      The user received trichotest results indicating finasteride is ineffective for them, and they plan to use dutasteride mesotherapy and add cetirizine to minoxidil. They seek advice on incorporating dutasteride into their regimen.

      community 26 male 1 year 9 month therapy (fin,min,dut, micro needling)

      in Progress Pictures  441 upvotes 1 year ago
      A 26-year-old male shared his hair loss treatment journey using finasteride, minoxidil, dutasteride, and microneedling, noting dissatisfaction with hair thickness but hoping for improvement. Users discussed side effects, treatment effectiveness, and shared personal experiences with similar treatments.