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      community Is RU58841 or pyrilutamide a stronger topical anti-androgen?

      in Treatment  3 upvotes 3 months ago
      The conversation discusses adding either RU58841 or pyrilutamide to a hair loss treatment regimen that already includes oral dutasteride and oral minoxidil. RU58841 is considered the stronger anti-androgen but may have more side effects.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Naturally high T (1,100+) causing diffuse thinning while on Dut

      in Chat  23 upvotes 1 month ago
      A 26-year-old male with high testosterone is experiencing diffuse hair thinning despite using a comprehensive treatment regimen including dutasteride, oral minoxidil, RU58841, ketoconazole shampoo, microneedling, and low-level laser therapy. Suggestions include adjusting dutasteride dosage, monitoring iron levels, and consulting a dermatologist for further evaluation.

      community Source for Pyrilutamide has disappeared

      in Treatment  21 upvotes 3 years ago
      Anageninc stopping the sale of Pyrilutamide due to a cease and desist order from Kintor, with some speculating that it was either a hoax or subpar product.

      community Why haven’t we seen anything about this

      in Research/Science  18 upvotes 5 years ago
      A double blind, placebo-controlled study that looked into the potential effectiveness of topical fluridil for treating male androgenetic alopecia, showing increased anagen to telogen ratios with no reported side effects on libido or sexual performance.

      community Has anybody tried RU58841 and pyrilutamide together?

      in Chat  9 upvotes 9 months ago
      RU58841 and pyrilutamide are being discussed as potential hair loss treatments, with some users reporting side effects. There is interest in these treatments as alternatives to 5ar inhibitors and oral minoxidil due to concerns about safety and side effects.

      community How finasteride or DUT works for me

      in Finasteride/Dutasteride  1 upvotes 2 months ago
      Some users experience side effects from finasteride and switch to alternatives like pyralutamide and a finasteride-minoxidil mix. These alternatives may reduce side effects while helping with hair loss.

      community Looking for KX826 (pyrilutamide) success stories

      in Treatment  12 upvotes 1 year ago
      A user ordered pyrilutamide (KX826) to stop hair loss and is seeking success stories. Replies indicate that it's too early to evaluate the product's effectiveness, as it takes several months to see results.

      community Trichotest Results: no Finasteride

      in Finasteride/Dutasteride  5 upvotes 4 years ago
      The user received trichotest results indicating finasteride is ineffective for them, and they plan to use dutasteride mesotherapy and add cetirizine to minoxidil. They seek advice on incorporating dutasteride into their regimen.

      community Is fluridil cost-efficiency absolute garbage?

      in Product  1 upvotes 2 years ago
      Fluridil is considered safe with moderate effectiveness for hair loss, but its cost of €50 per month is seen as high compared to other treatments. The user is considering Pyri as a more cost-effective option and is seeking success stories about Fluridil's ability to stop hair loss without side effects.

      community 7 months dutasteride(1 mg) progress

      in Progress Pictures  76 upvotes 8 months ago
      Dutasteride, at 1 mg daily, was used for hair regrowth, with initial shedding and side effects like watery semen and increased libido. The user previously tried finasteride and minoxidil but switched to dutasteride for stronger, sustained results.
      Dut + Min, 5 Months In, No Results — Need Advice

      community Dut + Min, 5 Months In, No Results — Need Advice

      in Treatments  163 upvotes 8 months ago
      A 28-year-old experiencing worsening hair loss despite using Dutasteride and oral Minoxidil is considering exosome therapy and possibly switching treatments due to side effects. They seek advice on whether to continue with Dutasteride or try alternatives like Pyrilutamide or topical supplements.

      community 7 years of maintenance without finasteride

      in Progress Pictures  17 upvotes 6 months ago
      The user maintained their hair for 7 years using alfatradiol, fluridil (later switched to pyrilutamide), minoxidil 5%, and Nizoral shampoo without finasteride due to side effects. Despite some family history of hair loss, the user believes their hair loss is not aggressive.

      community [Serious] Experience with grey-market KX-826 (Pyrilutamide)

      in Research/Science  2 upvotes 2 years ago
      The user experienced reduced hair loss using grey-market KX-826 alongside Minoxidil foam, achieving better results with Minoxidil liquid but restricted to foam due to an allergy. Initial side effects included shortness of breath, racing heart, and dizziness, which subsided after the first week.

      community No shed no results 4 months of daily 0.5 mg of dutasteride

      in Progress Pictures 2 months ago
      The user has been taking 0.5 mg of dutasteride daily and using ketoconazole shampoo twice a week for four months, but sees no significant hair loss improvement. Others in the conversation believe the user is not experiencing hair loss and suggest the user might be overly concerned about their hairline.

      community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

      in Update  36 upvotes 7 years ago
      The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

      community Experience with CB (Breezula)?

      in Research/Science  4 upvotes 5 years ago
      CB 03 01 (Breezula) was tried for hair loss but showed no significant improvement, with issues in dissolving and application. Finasteride and dutasteride remain the most effective treatments, while minoxidil is also used; CB's effectiveness is questioned, and topical alternatives like bicalutamide are considered.

      community Alfatradiol causing shedding ?

      in Treatment  1 upvotes 1 year ago
      The user experienced a sudden decrease in hair density after starting alfatradiol while already using finasteride. Another user mentioned that initial shedding can occur with hair loss treatments, but it may not last long.