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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Grinding up Fin pills, mixing them with MINOX?

      in Finasteride  4 upvotes 8 years ago
      Mixing ground finasteride pills with Minoxidil for topical use, with concerns about effectiveness and side effects. Users suggest using professionally formulated topical finasteride instead.

      community 3 month of profess with fin and minoxidil

      in Progress Pictures  123 upvotes 2 years ago
      The conversation discusses a user's three-month progress using topical finasteride once a day, 6% minoxidil at night, and weekly dermastamping at 1.25mm for hair loss. Commenters note the impressive results and discuss application methods and safety precautions for family members.

      community 16 months of Fin (M47). 1mg 3x per week.

      in Progress Pictures  156 upvotes 2 years ago
      A 48-year-old man shared his 16-month hair regrowth journey using finasteride 1mg three times a week, noting some regrowth and emphasizing patience. He chose not to use it daily to minimize side effects, and while some users debate the effectiveness, he confirms maintenance and possibly some regrowth.

      community Finasteyd topical 0.025% minoxidil and caffeine action

      in Progress Pictures  102 upvotes 1 year ago
      The user "OP" uses a combination of topical minoxidil 5%, finasteride 0.025%, and caffeine to combat hair loss, with noticeable results over 5-6 months. Side effects include unwanted body hair growth and an itchy scalp, but no significant sexual side effects.

      community M23 , on finaestride and minoxidil for 4.8 months

      in Progress Pictures 3 years ago
      . This conversation is about a user's progress while using minoxidil and finasteride to treat hair loss, with emphasis on taking oral finasteride at night before bed for optimal results. They also discuss the brand of medication being used (Morr F 5%) and the importance of taking a generic version of the same drug.

      community Since there is so much hype for cosmeRNA and HMI-115...

      in Chat  44 upvotes 3 years ago
      Exploring different treatments for hair loss, such as cosmeRNA and HMI-115 which are small interference messenger RNA that inhibits the DHT receptor and an antibody that binds to the prolactin (PRL) receptor respectively; and researching mechanism and environment of hyperresponders.

      community Has anyone tried Eucapil. It's available in Europe.

      in Product  1 upvotes 1 year ago
      Eucapil, containing fluridil, is used for hair loss but has impractical packaging. Some users find it effective for maintenance, while others suggest alternatives like anageninc with pyrilutamide.

      community Min/Fin is pure magic. Seriously. Read below

      in Treatment  9 upvotes 1 year ago
      A user reported significant hair growth improvements using 1mg finasteride and 2.5mg minoxidil daily, despite minor side effects. The doctor advised against combining multiple treatments to identify what works.

      community Min/Fin/Needle July 2024-March 2026

      in Progress Pictures  33 upvotes 3 months ago
      The user experienced hair regrowth and improved hair density using oral finasteride and topical minoxidil, with microneedling as an additional treatment. They are considering a hair transplant for low-density areas but are uncertain due to existing follicles.

      community 4 month Min+Fin progress (topical)

      in Progress Pictures  124 upvotes 2 years ago
      A user shared their 4-month progress using a topical solution with 5% minoxidil and 0.1% finasteride, applied twice daily. They reported good results despite occasional missed applications.
      (M24) Anything before min/fin? time to start?

      community (M24) Anything before min/fin? time to start?

      in General  63 upvotes 1 year ago
      The user is experiencing hair thinning and shedding despite no family history of male pattern baldness. They are considering starting treatments like Minoxidil or finasteride.

      community Wednesday after micro needling through Friday today.

      in Treatment  1 upvotes 1 year ago
      The user is using oral and topical minoxidil, finasteride, dutasteride, and considering adding rosemary and pumpkin saw palmetto to their regimen. They report significant hair growth, especially with dutasteride, and are considering increasing their dose and adding RU58841.

      community Dr. Rassman vs Kevin Mann on Eucapil

      in Treatment  4 upvotes 5 years ago
      Eucapil is discussed as a potential hair loss treatment with some believing it to be effective, though its efficacy compared to finasteride is debated. It is considered an anti-androgen treatment, often used alongside other treatments like minoxidil and finasteride, but lacks independent studies to fully support its effectiveness.

      community 4 month update Fin/Min/Dermatamp

      in Is this regrowth?  30 upvotes 1 year ago
      The user reported gradual hair regrowth after 4 months using oral finasteride, topical minoxidil, dermastamping, and vitamins C and D3. They noted the use of a 1.25mm dermastamp and discussed sourcing finasteride in Canada.

      community On Fin 1 mg for past 4 months, plus micro needling weekly

      in Progress Pictures  17 upvotes 1 year ago
      A 49-year-old man has been using 1 mg of finasteride daily and microneedling weekly for four months to address hair loss, with no side effects and noticeable progress. He shares his experience and encourages others to consider treatment options without fear.

      community M28 5 Month insane progress, Fin&Min

      in Progress Pictures  78 upvotes 4 months ago
      A user shared their impressive hair regrowth progress after 5 months using 1mg oral finasteride every other day, 2.5mg oral minoxidil daily, weekly dermastamping, and daily scalp massages. They reported no side effects and began seeing improvement after 2.5 months.

      community M29 - 4 YEARS on Dutasteride - almost no progress

      in Chat  6 upvotes 5 months ago
      The user has been on a comprehensive hair loss treatment regimen for four years, including Dutasteride, topical and oral Minoxidil, and various other treatments, but has seen little progress and is considering a hair transplant. Despite trying multiple therapies, including PRP and exosome injections, the user is still experiencing hair thinning and is hesitant about trying peptides due to potential cancer risks.