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PP405 is a topical gel being tested for hair regrowth in adults with androgenetic alopecia. Volunteers aged 18-55 are needed for a 16-week trial in several US locations.

A 17-year-old is concerned about hair thinning and unable to see a dermatologist for a year. They are advised to consider using topical minoxidil and possibly finasteride in the future.

The user follows an intensive hair loss protocol including dutasteride, biotin, black tea, pumpkin seed oil, peppermint shampoo, rosemary conditioner, mukemame, soy milk, lycopene, garlic, magnesium, chamomile, spicy food, citrus bergamot, zinc, multivitamins, kefir, and Greek yogurt. They plan to alternate between pumpkin seed oil and safflower oil and will share before and after pictures.

The user has been using 0.5mg Dutasteride daily and topical Minoxidil but is experiencing worsening hair density and is considering switching to Finasteride, increasing the Dutasteride dose, or adding RU58841. They are also considering microneedling and have concerns about the effectiveness of generic Dutasteride compared to branded versions.

An 18-year-old male switched from topical finasteride and minoxidil to oral dutasteride for diffuse hair loss and saw improvement without side effects, despite experiencing scalp itch and shedding. Commenters noted significant hair regrowth and were surprised by his young age and appearance.

The conversation is about a hair loss treatment regimen that does not include finasteride. Specific treatments used are not mentioned.

The user experienced hair shedding after using finasteride and topical minoxidil since August 2024, and briefly adding oral minoxidil in early 2025. They suspect the shedding might be due to the oral minoxidil, a bad batch of finasteride, or a normal shedding cycle, and are also experiencing an itchy scalp and acne.

Topicals like minoxidil and finasteride should reach the scalp, but excessive massaging can cause hair to fall out. The evaporation felt is likely the carrier substances like alcohol or propylene glycol.

The user is experiencing significant hair loss and is considering treatments like minoxidil, finasteride, and possibly a hair transplant. They are advised to consult a dermatologist and consider oral minoxidil and dutasteride, while being aware of potential side effects and the need for ongoing treatment.

A 19-year-old is experiencing hair regrowth using 0.5mg dutasteride, topical minoxidil at night, topical redensyl in the morning, and weekly dermarolling. They have been on the treatment for a month and plan to share monthly updates over the next two years.

User mixed RU58841 with stemoxydine, experienced no side effects. Mixing RU58841 with fluridil caused chest tightness.

After a year on dutasteride and oral minoxidil, the user experienced significant hair regrowth, improving from Norwood 2 to almost Norwood 1. They added RU58841, microneedling, rosemary oil, GHK-Cu, and annurca apple supplement to their regimen and are now noticing hair loss in the temple area.

Despite using finasteride for 1.5 years and oral minoxidil for nearly a year, hair shedding continues, prompting a dermatologist visit. Users discuss the inconsistency of treatments, with some experiencing worsened hair conditions and others noting side effects like increased shedding after workouts.

The user has tried various treatments like Dutasteride, RU58841, Minoxidil, Finasteride, Spironolactone, Pyrilutamide, and Ketoconazole for hair loss without success and is considering a scalp biopsy to diagnose another condition. Others suggest consulting a dermatologist and possibly getting a biopsy, as the issue might not be typical male pattern baldness.

User has been using topical finasteride and minoxidil since May, previously used a spray version since January. They are seeing vellus hairs and have added weekly microneedling to their routine.

A user experiencing significant hair loss found they had a severe vitamin D deficiency and was prescribed 50,000IU vitamin D pills, likely to be taken weekly. They are questioning if the deficiency could be the cause of their hair loss and if correcting it could stop the shedding and improve hair recovery.

The user experienced aggressive hair loss despite using oral finasteride and minoxidil, with additional issues like dandruff and eyebrow hair loss. They are considering switching to oral minoxidil and dutasteride due to scalp inflammation and lack of improvement.

The user experienced no improvement in hair loss after using a dermatologist's minoxidil 10% and finasteride 0.1% solution, clotrimazole, daily dermarolling, and multivitamins. They plan to switch to oral finasteride and reduce dermarolling to once a week.

The user is using a hair loss treatment involving dutasteride, minoxidil, finasteride, microneedling, and supplements like multivitamins, D3 K2, and Omega 3 fish oil. They are considering adding tretinoin and are open to suggestions while managing gut issues.

The user reports progress in hair regrowth using finasteride every other day, topical minoxidil once daily, ketoconazole twice a week, and Vitamin D3 with zinc. They note improvement in temple areas and the appearance of baby hairs.

Hair regrowth after telogen effluvium, with the user experiencing hair loss at the temples and regrowth after taking omega-3/fish oil tablets. Suggestions include consulting a dermatologist and considering supplements like Biotin, Zinc, and Vitamin D.

The user has been using finasteride and minoxidil for hair loss but experienced worsening temple recession. They suspect they might be more sensitive to testosterone and are considering trying RU58841 or CB 03 01 as additional treatments.

User considers trying RU58841 for hair loss and asks for advice on its effectiveness and application. Responses vary, with some reporting positive results and others warning about potential risks or lack of change.

PTD-DBM is being explored for hair regrowth by targeting CXXC5, with clinical trials expected after pre-clinical studies. Users express anticipation and skepticism about its effectiveness.

The user experienced hair regrowth using minoxidil and finasteride but reported scalp itching, possibly due to the liquid form of minoxidil. They also use ketoconazole shampoo to manage flakes, which they clarify are not dandruff.

Shedding after two months of using 1.5 mg finasteride is a common concern. It's often a normal part of the hair growth cycle.

Veradermics' phase 2 trial of slow-release oral minoxidil shows promising hair regrowth with minimized side effects, gaining significant attention and funding. PP405 is also noted for its potential as a side-effect-free alternative.

The user has been using 1mg finasteride daily, 2.5mg minoxidil daily, topical tretinoin three times a week, and topical minoxidil daily from June 2023 to June 2025 without noticeable improvement in hair loss. Suggestions include switching to dutasteride and increasing oral minoxidil to 5mg daily, but concerns about long-term health effects are raised.

The user experienced hair thinning despite using finasteride and switched to a ketoconazole shampoo without sulfates to address scalp itching and dandruff. They hope this will stop further hair thinning.

The user experiences heavy shedding after one year of using 1mg oral finasteride and twice-daily topical minoxidil, recently adding microneedling and daily Nizoral. They also take supplements like vitamin D and biotin.