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      community Are we underestimating systemic absorption with homemade/generic Topical Fin? (HPCH vs. PG/Ethanol formulations)

      in Research/Science  4 upvotes 2 months ago
      Topical finasteride may have higher systemic absorption and lower efficacy when using a Propylene Glycol/Ethanol formulation compared to the hydroxypropyl chitosan (HPCH) formulation. The safety profile of topical finasteride relies heavily on the HPCH formulation, and using standard solutions might lead to different pharmacokinetics.

      community New regimen started after 4 years of little progress

      in Treatment  5 upvotes 3 years ago
      The user is trying a new hair loss regimen including Spirolactone, Finasteride, oral Minoxidil, microneedling, and various supplements. They are experiencing increased shedding and seeking advice on microneedling and treatment effectiveness.

      community Pyrilutamide vs topical finasteride

      in Finasteride/Dutasteride  2 upvotes 9 months ago
      The user is considering switching to topical finasteride or pyrilutamide to stabilize hair loss before a hair transplant, currently using oral minoxidil and finasteride. Suggestions include sticking to the current regimen as it is already potent, and caution against using pyrilutamide from unreliable sources.

      community 7 years progress against hair loss

      in Progress Pictures  268 upvotes 1 year ago
      A 27-year-old shares his 7-year journey using finasteride and 4 years with minoxidil to combat hair loss, experiencing cycles of shedding and regrowth. Despite emotional challenges, he finds the treatments worthwhile, though he still faces insecurities and uncertainties about shedding phases.

      community Anyone else realize how many younger guys are balding?

      in Chat  262 upvotes 1 year ago
      Many younger men are experiencing hair loss due to genetics, diet, stress, and lifestyle changes. Treatments like finasteride and minoxidil are mentioned, with some users noting improvements.

      community Welcome to Tressless, OG! Ötzi was dark-skinned and balding.

      in Chat  11 upvotes 2 years ago
      The conversation discusses that genetic analysis of the Iceman Ötzi shows he had male-pattern baldness and dark skin, with a joke about using beards and tattoos to distract from hair loss. No specific hair loss treatments are mentioned.

      community Checking in with my post-fin symptoms

      in Finasteride  5 upvotes 9 years ago
      A user reports persistent sexual side effects three months after stopping finasteride, despite a healthy lifestyle and supplements. They express concern over the lack of libido and infrequent erections.

      community at what point does RCP no longer benefit?

      in Treatment  4 upvotes 1 year ago
      A user is using Minoxidil, finasteride, saw palmetto, and Minimalist RCP serum to address hair thinning, with some success but concerns about the long-term benefits of Minimalist. They plan to continue Minoxidil and finasteride for another year before considering a hair transplant.

      community My almost 9 year journey with finasteride and minoxidil

      in Progress Pictures  273 upvotes 6 months ago
      A user shared their 9-year experience with finasteride and 3 years with oral minoxidil, noting positive hair maintenance and regrowth without significant side effects. They are considering a hair transplant but are generally satisfied with their current hair condition.

      community new way to activate stem cells to make hair grow

       44 upvotes 7 years ago
      Stem cell-related treatments and drugs like RCGD423 and WAY are being tested for hair growth. Clinics are conducting tests on patients who haven't had previous treatments.

      community oral minoxidil collagen contradiction

      in Minoxidil  13 upvotes 1 year ago
      The conversation discusses concerns about oral minoxidil potentially aging the face by affecting collagen, questioning its systemic effects. The user has successfully used topical minoxidil for years and is hesitant to switch to oral minoxidil.

      community 2.5 Years Fin/Min - progress pics

      in Progress Pictures  1296 upvotes 6 months ago
      The user achieved significant hair regrowth using topical Minoxidil and Finasteride over 2.5 years, with results plateauing after a year. They experienced minimal side effects and used microneedling to enhance results.

      community Chances of GT20029 hitting the black market?

      in Treatment  11 upvotes 1 year ago
      The conversation is about the potential availability of GT20029 on the black market and whether users would try it. Participants advise waiting for phase 3 trial results to ensure safety and efficacy.

      community HLT Megathread on HMI-115 (key takeaways in comments)

      in Research/Science  39 upvotes 3 years ago
      HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

      community Iron, Anemia, DNA testing, and bloodwork

      in Research/Science  2 upvotes 6 months ago
      The conversation discusses personal experiences with hair loss and highlights the potential impact of anemia and nutrient deficiencies on hair health. Treatments mentioned include changing shampoo/conditioner, taking MSM, collagen, hyaluronic acid, astaxanthin, B12, folate, and bovine blood capsules.
      Topical Treatment Progress

      community Topical Treatment Progress

      in Journals / Progress Pictures  53 upvotes 1 month ago
      The user reported healthier, firmer, and thicker hair follicles with minimal regrowth at the front after using Regenera Activa, topical finasteride, minoxidil, tretinoin, caffeine solution, and vitamin D supplements. Hair loss has stabilized with no side effects.

      community One year on finasteride has reversed some aging

      in Chat  198 upvotes 6 months ago
      Finasteride and minoxidil use resulted in a more youthful appearance and improved skin. There is debate about their effects on collagen and skin aging, with no solid evidence supporting significant changes due to finasteride.

      community What to look Forward to in 2025

      in Research/Science  19 upvotes 1 year ago
      Hair loss treatments are advancing, with Coegin Pharma's FOL005 expected this year and Breezula potentially later. Pyrilutamide is available but not very effective, while Kintor's products face skepticism; traditional treatments like finasteride and minoxidil remain dominant.

      community If PP405 goes systemic this would be quite catastrophic

      in Research/Science  5 upvotes 1 year ago
      Concerns about the potential systemic effects and safety of PP405 for hair loss, with discussions on its comparison to existing treatments like finasteride and minoxidil. Users express skepticism about untested research chemicals and emphasize the importance of clinical trials to ensure safety and efficacy.
      Time for change or just in my head?

      community Time for change or just in my head?

      in General  128 upvotes 11 months ago
      A 20-year-old is experiencing hair thinning despite using minoxidil inconsistently for 1.5 years and is considering adding finasteride due to concerns about side effects. They are unsure whether to increase minoxidil application, start finasteride, or if the hair loss is exaggerated in their perception.

      community Terminal hairs growing in, but derm still says I’m going to go bald in the years to come??

      in Chat  6 upvotes 10 months ago
      A 30-year-old woman with a history of anemia and low vitamin D experienced hair shedding, which improved after addressing nutrient deficiencies. Despite regrowth of terminal hairs, her dermatologist recommended treatments like minoxidil and spironolactone to prevent future bald spots, but she is cautious due to family history of hormone-related cancers.
      How cooked am i? (M17)

      community How cooked am i? (M17)

      in General  26 upvotes 10 months ago
      A 17-year-old is concerned about hair loss and shares photos for opinions. A user responds that the hair looks normal but is hard to assess from the images.