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      community So... any chinese suppliers for real pyri?

      in Research/Science  6 upvotes 1 year ago
      The conversation discusses sourcing pyrilutamide from China for hair loss treatment, highlighting its potency compared to other AR antagonists like bicalutamide and RU58841. The user expresses interest in trying pyrilutamide despite mixed results in clinical trials.

      community RU58841, 8% HPLC-MS done by jano, they legit

      in Research/Science  7 upvotes 4 years ago
      The conversation is about testing the effectiveness of RU58841 for hair loss, with the user planning to increase their dose to 30 mg per day along with 20 mg of Minoxidil. The test results showed approximately 70 mg/ml, which the user considers a good result.

      community Trichosol, polyethylene glycol, and DMSO

      in Minoxidil  3 upvotes 2 years ago
      The user experiences irritation from alcohols in minoxidil and is considering alternatives like trichosol mixed with polyethylene glycol or DMSO. They seek advice on the best nonirritating option.

      community Minoxidil and the GUT conexion

      in Minoxidil  48 upvotes 1 year ago
      Minoxidil and finasteride may affect digestion, potentially causing issues like GERD, constipation, and inflammation. The user plans to stop minoxidil for a month and consult a nutritionist about diet changes.

      community RU58841 dilution in Minoxidil Vs PG+Ethanol

      in Treatment  5 upvotes 2 years ago
      RU58841 mixed with Minoxidil seems less effective over time, so the user plans to switch to a PG and Ethanol dilution for better results. They also consider using rosemary oil with Minoxidil to enhance RU58841 absorption.

      community Has anyone tried this Ru58841 from Amazon ?

      in Product  3 upvotes 9 months ago
      RU58841 from Amazon is unreliable, with users reporting no benefits and side effects like eye swelling and chest pain. Rudirect is recommended for purchasing in Europe.

      community DIY Minoxidil mix with Fin, Caffeine, Cetirizine, and Melatonin?

      in Treatment  4 upvotes 1 year ago
      A user plans to create a custom topical solution by adding finasteride, caffeine, cetirizine, and melatonin to a minoxidil bottle, questioning the stability and effectiveness of this mix. Concerns include potential crystallization and solution muddiness with added ingredients.

      community Deoxyribose sugar gel worked just as well as minoxidil

      in Research/Science  18 upvotes 1 year ago
      A deoxyribose sugar gel may work as well as minoxidil for hair regrowth by boosting blood supply to hair follicles. Some users discuss combining it with minoxidil and cetrizine, but caution is advised due to potential risks and lack of consistent results.

      community Alcohol Free Minoxidil? Azaleic Acid added?

      in Minoxidil  4 upvotes 9 years ago
      The user is experiencing a burning sensation from using minoxidil and is considering trying an alcohol-free version with added azelaic acid. They are also using finasteride and seeking reliable, low-cost alternatives for minoxidil.

      community Xeljanz....the magic drug!!!

       2 upvotes 7 years ago
      A user experienced significant hair regrowth from Xeljanz after severe alopecia but can no longer afford it. They are seeking ways to obtain the medication despite its high cost and potential side effects.

      community Question about RU58841 in minoxidil

      in Minoxidil  5 upvotes 5 years ago
      The user is considering adding RU58841 to liquid minoxidil without propylene glycol (PG) due to an allergy and is asking if this combination is effective and if PG is necessary. They have been using finasteride and minoxidil foam, plan to use RU58841 with liquid minoxidil in the evening, and continue finasteride.

      community important questions about RU58841

      in Research/Science  3 upvotes 2 years ago
      The user has been using finasteride for hair loss and is considering adding RU58841. They ask about RU58841's effectiveness, potential heart side effects, duration of action, dosage increase over time, transitioning to GT20029, and where to find the liquid form.

      community Group Buy for MR antagonist finerenone

      in Product  11 upvotes 3 years ago
      User discusses group buy for finerenone, a third-gen mineralocorticoid antagonist for hair loss treatment. Finerenone inhibits TGFb, NOX, and ROS, and improves renal and cardiac function; topical dose should be no more than 10mg per day.

      community ghk-cu is potent 5-ar inhibitor?

      in Product  10 upvotes 2 years ago
      GHK-Cu is a potent inhibitor of the type 1 5-alpha reductase enzyme in hair follicles, which may reduce hair loss without the side effects associated with type 2 5-alpha reductase inhibitors. The user previously experienced side effects with 5-alpha reductase inhibitors and is considering GHK-Cu as an alternative.

      community A scary individual report of RU58841.

      in Research/Science  33 upvotes 1 year ago
      RU58841 caused severe side effects like heart palpitations and shortness of breath, leading the user to stop using it. Minoxidil and finasteride were effective without side effects, while RU58841's safety and effectiveness remain uncertain.

      community Can amino acids help with AGA

      in Chat  4 upvotes 2 years ago
      Amino acids like lysine, methionine, and cysteine may help with androgenetic alopecia when taken in high doses along with a DHT blocker. Users discuss combining these with treatments like Minoxidil, finasteride, and RU58841.

      community RU58841 Users: How chemically unstable is RU58841 in practice?

      in Technology  2 upvotes 9 months ago
      The conversation discusses using RU58841 mixed with topical minoxidil for hair loss, noting its chemical instability and storage challenges. A user shares their experience using RU58841 with ethanol and propylene glycol, mentioning no significant results yet.

      community Why are there no proper phase 3 trials for RU

      in Chat  4 upvotes 2 months ago
      RU58841 lacks FDA approval due to financial and safety concerns, including potential cardiological side effects. The company abandoned further research, and users report adverse effects like heart palpitations and gynecomastia.

      community Making PG free solution at home

      in Product  1 upvotes 2 years ago
      A user wants to make a solution for RU58841 and finasteride powder using only glycerin and asks if ethanol is necessary. They are seeking advice on whether glycerin alone is sufficient.

      community RU-58441 Janoshik test result of Made-In-China Supplier

      in Product  27 upvotes 6 months ago
      A user ordered RU58841 from a Chinese supplier, found it to be less than 99% pure, and plans to try a different seller next time. Concerns were raised about impurities, but the user believes they are likely inactive fillers rather than harmful substances.

      community RU-58841 Lung Disease Possibility | Chest pain, "heart issues", etc

      in Treatment  22 upvotes 2 years ago
      Some users of RU-58841 report cardiovascular symptoms like heart palpitations and chest tightness, which may be linked to its metabolites causing lung disease. The safety of RU-58841 is uncertain due to lack of long-term data and concerns about product purity, especially from gray market sources.

      community Ru with gloves because of Systemic absorption?

      in Research/Science  10 upvotes 2 years ago
      The conversation is about whether to use gloves when applying 5% RU58841 to avoid systemic absorption and if washing hands with water is sufficient. Users question the concern, noting it is applied to the scalp.

      community [Nov 2019] The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression

       22 upvotes 6 years ago
      A peptide from Japanese water chestnut fruit may help with hair loss by suppressing DHT's effect on hair follicle cell death, potentially serving as a finasteride alternative. The treatment's effectiveness and safety in humans remain uncertain.

      community Ginsenoside enriched formulation

      in Treatment 1 year ago
      Panax ginseng, specifically a ginsenoside-enriched formulation, is suggested as a potential hair growth treatment alongside finasteride and minoxidil. The user is considering trying panax ginseng despite limited availability and evidence.