TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hairgrowth and reduce hair follicle sensitivity to DHT.
Creatine may counteract minoxidil's hairgrowth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.
Microneedling with minoxidil significantly boosts hairgrowth, even for non-responders to minoxidil alone. The routine includes a 1.5mm dermaroller weekly and minoxidil twice daily, with some users adding finasteride and tretinoin.
Intense microneedling with heavy pressure and bleeding did not improve hairgrowth after 4 months. The user advises against this method, noting no benefits and potential harm, and mentions using minoxidil without success.
PP405 is the most promising future treatment for hair loss, aiming to reactivate dormant hair follicles. Clascoterone 5% is the most promising near-term drug, while current strategies include using finasteride or dutasteride to stabilize hair loss and minoxidil to stimulate growth.
Microneedling combined with 5% Minoxidil and finasteride significantly improves hairgrowth compared to using Minoxidil or Minoxidil with finasteride alone. The combination treatment is safe and effective, but further research is needed due to small sample size and short study duration.
A user improved their hair health by taking 50,000 IU of vitamin D3 weekly due to a deficiency. Others discussed the potential link between vitamin D and hairgrowth, with some sharing similar experiences and emphasizing the importance of monitoring vitamin D levels and consulting with doctors.
Bee venom at 0.001% concentration was more effective than 2% minoxidil in promoting hairgrowth in mice, possibly due to increased growth factors and reduced inflammation. Caution is advised due to potential allergic reactions and the reliance on animal data.
The user is using a hair loss regimen involving 2ddr applied twice daily, tretinoin weekly, and occasionally micro-needling. They report feeling increased scalp thickness and seeing some hairgrowth progress.
The conversation discusses using Biotin 10000mcg with Keratin and DHT blockers for hairgrowth. The user seeks advice on other community-recommended options.
Cbum's hair transplant is criticized for looking unnatural and not blending well, with some suggesting better results were expected given his resources. Discussions also cover the effects of steroids and finasteride on hair loss and muscle growth.
User had a hair transplant and used a finasteride and minoxidil spray for 6 months with no results. After adding finasteride tablets for 1 month, they saw significant hairgrowth improvement.
Capronium Chloride and Trichoxidil are suggested as better alternatives to Minoxidil for hairgrowth without heart side effects. The Japanese Dermatological Association recommends topical Minoxidil over Capronium Chloride.
The conversation is about someone who had success using retinol with minoxidil for hairgrowth, but experienced shedding with Retin A (tretinoin). They are asking if others have tried retinol with minoxidil and what their results were.
User xEternex tries hair regrowth with daily broccoli sprouts, apple extract containing procyanidin b2, and microneedling. Others discuss potential issues with the experiment and share their experiences with vegetable consumption and hairgrowth.
A user shared progress on hair regrowth using 5mg oral minoxidil and 0.5mg oral dutasteride daily, noting small hairgrowth and no significant side effects except bushier eyebrows. The conversation includes encouragement, personal experiences with hair loss treatments, and discussions on the effectiveness of microneedling.
The conversation discusses microneedling for hair loss, with one user trying 0.3mm daily without feeling pain and questioning its effectiveness. Another user suggests that 0.3mm is too shallow and recommends 0.5mm twice a week or 0.75mm once a week for hairgrowth.
The user shared a one-year progress of hair regrowth using topical minoxidil and dutasteride, along with microneedling and scalp massages. They experienced significant hairgrowth without side effects.
CBD in an emu and lanolin oil preparation showed a 100% increase in hairgrowth, but the effectiveness may partly come from the oils. Users discussed proper CBD dosage, preparation methods, and skepticism about the study's quality.
A man used finasteride, minoxidil, and a derma pen for a year to improve hairgrowth with no significant side effects. He plans to continue the treatment and explore new options.
PP405 and ABS-201 are promising treatments for male pattern baldness. PP405 shows rapid hairgrowth in human trials, while ABS-201 shows significant regrowth in animal studies but is still in early human trials.
Oral minoxidil dosing should be based on body weight to minimize side effects, with higher doses increasing risks like pericardial effusion. Combining oral minoxidil with topical treatments and finasteride can improve hairgrowth, but regular heart health monitoring is essential.
A user shared progress pictures after 25 days of using Minoxidil, microneedling, and recently started topical finasteride for hair loss. Some commenters are skeptical about the results, while others notice new hairgrowth.
The method combines finasteride, minoxidil, intense leg exercises, and cold exposure to treat androgenetic alopecia. It aims to boost metabolism and reduce androgenic effects, enhancing hairgrowth.
Fin and minoxidil, in combination with dermarolling, as an effective path for hairgrowth. The post also provides advice about needle depth and frequency, as well as other treatments (foam and oral) which may be beneficial.
Essential oils like lavender, peppermint, and rosemary may help with hairgrowth, similar to Minoxidil. Turmeric with piperin might be as effective as Finasteride without side effects.
The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.
A 25-year-old who has been using minoxidil and finasteride for 4 years to treat hair loss, underwent a successful FUE hair transplant in Mumbai, India, in April 2023. The user reported positive results, including increased hair density and reduced frizziness, and plans to continue treatment for further growth.
Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.
Hair loss treatments, specifically finasteride and minoxidil, being used by wealthy individuals to combat their genetic predisposition to baldness. It also discussed other potential treatments such as RU58841 and dutasteride.