The conversation is about finding an alternative hairgrowthstimulator for someone who cannot use Minoxidil due to heart issues. The person is currently using topical dutasteride, azelaic acid, and occasional microneedling, and is considering options like retinyl palmitate, latanoprost, certizine, or tadalafil.
Mallia Aesthetics has developed MAL-838, a hormone-free product derived from sCD83, which stimulateshairgrowth without disrupting the skin microbiome. sCD83 promotes hairgrowth by activating hair follicles and preventing cell death, offering a localized treatment without systemic side effects.
Low-level laser therapy (LLLT) stimulateshairgrowth but current devices are expensive. A proposed non-profit project aims to create affordable, 3D-printed LLLT devices and collect data on their effectiveness.
Hair loss treatments are generally categorized as anti-androgens, like finasteride and RU58841, which prevent hair loss by targeting DHT, and growthstimulators, such as minoxidil, rosemary oil, microneedling, and LLLT, which promote hairgrowth by increasing blood flow and growth factors. The user is seeking to confirm these categories and understand if there are other treatments or mechanisms of action.
A Dutasteride Simulator predicts serum dutasteride, serum DHT, and scalp DHT levels using models from research papers. It simulates various dosing schedules to determine steady-state effects and visualizes outcomes, including hairgrowth-related scalp DHT suppression.
Amplifica starting clinical trials for new hair loss drug. SCUBE3 protein discovered, stimulateshairgrowth, could be alternative to Minoxidil and Finasteride.
Microneedling stimulateshairgrowth through stem cell activation during wound healing, not just increased blood flow. Other methods like showers or supplements don't replicate this effect.
Glycosaminoglycans are important for hairgrowth, and combining minoxidil with tretinoin and Biopeptide-CL may enhance hairgrowth by boosting glycosaminoglycan levels and improving the hair follicle environment. Users discussed the potential effectiveness and future of these treatments.
A user shared a hairgrowth stack using minoxidil sulfate, valproic acid, bimatoprost, blue copper peptide, and other ingredients, emphasizing a gel-based formula for better skin tolerance. Another user suggested adding a 5-alpha-reductase inhibitor like finasteride or dutasteride for more effective long-term results.
Calecim (PTT-6) Advanced Hair System is a 6-week hair restoration product using stem cell-derived ingredients to stimulate hairgrowth. Users are skeptical, calling it overpriced and ineffective, suggesting alternatives like LLLT devices or PRP treatments.
How oral minoxidil and topical sildenafil (similar to Viagra) are used for hairgrowth by increasing blood flow to the scalp, and potential side effects of combining these treatments with other drugs.
Finasteride prevents further hair loss by blocking DHT, while minoxidil stimulateshairgrowth by prolonging the active phase of hair follicles. Stopping minoxidil can lead to loss of regrown hair because finasteride does not address the same growth mechanism.
The conversation discusses whether sunlight exposure affects hairgrowth or loss, with mixed anecdotes and theories but no clear consensus. Some suggest moderate sunlight can benefit hair by providing vitamin D, while others doubt its effectiveness compared to treatments like Minoxidil or finasteride.
PP405, a topical treatment, shows promise for hairgrowth by activating inactive follicles, with 66% of participants experiencing positive results. The treatment is well-tolerated and may proceed directly to Phase 3 trials, offering a potential alternative to minoxidil and finasteride.
PP405 is a new hair loss treatment in phase 2 trials that may promote hairgrowth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.
The user uses 1mg fin every other day, a topical solution of 5% min + 0.1% fin nightly, and seeks advice on oils for hairgrowth. Replies suggest oils are ineffective and recommend sticking with fin and min treatments.
Microneedling, combined with finasteride and minoxidil, appears to enhance hairgrowth, with users reporting noticeable improvements. The process involves using a 0.5mm derma roller, which some believe increases blood flow and stimulateshair follicles.
The user shared a 1.4-year hairgrowth journey using minoxidil and recently added micro-needling and finasteride, which significantly improved their hair. They also mentioned taking consistent photos for comparison and dermarolling once a week with a 1.5 mm needle.
The user experienced significant hairgrowth using topical finasteride and minoxidil but noticed nipple changes, suggesting early gynecomastia. They plan to stop the treatment and consider blood work to check hormonal balance.
Adipose-derived stem cell secretome showed significant improvement in hair density and growth, especially when combined with minoxidil, suggesting a synergistic effect. The study had limitations, including a small sample size and potential bias.
Dutasteride, especially at higher doses, is considered more effective than Minoxidil for hair regrowth by blocking DHT, which causes hair loss. Combining Dutasteride with Minoxidil may enhance hair recovery by prolonging the hairgrowth phase.
A user shared their experience using capsaicin from chili peppers and occasional topical minoxidil to promote hairgrowth, noting noticeable improvements without significant side effects. They previously experienced side effects from dutasteride and minoxidil but found the new regimen effective and manageable.
New potential hair loss treatment uses molecules from hairy moles to stimulate follicle growth. Topical solution requires less frequent application, like Botox injections a few times per year.
Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hairgrowth solutions.
The user shares a hair loss routine involving finasteride, B-Complex vitamins with biotin, pumpkin seed oil, apple cider vinegar, aloe vera, honey water, olive oil, and tea tree oil. They emphasize avoiding shampoo and using natural rinses to maintain scalp health and promote hairgrowth.
Minoxidil may suppress androgen activity in hair follicles, potentially aiding in hairgrowth and prostate cancer treatment. Users discuss the effectiveness of minoxidil and finasteride for hair maintenance and regrowth, with some preferring topical applications over oral due to safety concerns.
Minoxidil can prevent hair follicle miniaturization, not just stimulate hairgrowth. Finasteride and dutasteride don't work for everyone, suggesting DHT may not be the sole cause of hair loss; hair loss could be due to multiple factors, including autoimmune conditions.