Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.
PP405 shows significantly better early-stage hair regrowth results compared to minoxidil and finasteride, with 31% of users experiencing over 20% density increase in 4–8 weeks. Minoxidil and finasteride show minimal or no visible regrowth in the same timeframe.
The user experienced severe hair shedding from RU58841 and recovered by stopping its use and starting treatments including Minoxidil, Rosemary Verbenone, Stemoxydine, Aminexil, copper peptide serum, and specific shampoos. They also consistently used oral Finasteride and plan to try Minoxidil 10%.
The user treats hair loss with dutasteride, minoxidil, and tretinoin for about £280 a year by using dutasteride weekly due to its long half-life, while using minoxidil daily. Concerns about the shelf life and absorption of topical treatments were discussed, with some users suggesting alternative sources for these products.
Diffuse thinners often experience more hair regrowth with DHT blockers like finasteride, possibly due to less DHT sensitivity and the presence of miniaturized, not completely bald, follicles. However, regrowth varies widely among individuals, influenced by factors like genetics, the stage of hair loss, and treatment methods such as minoxidil, microneedling, and dermarolling.
PP405 shows promise in treating severe hair loss, with 31% of users experiencing over 20% hair density increase in four weeks, faster than minoxidil and finasteride. Some users are skeptical about the results' significance and long-term efficacy.
Maintaining a healthy lifestyle is crucial for hair health, and relying solely on treatments like Minoxidil, finasteride, or RU58841 without addressing overall health may not be effective. External treatments alone cannot compensate for poor health habits.
A user shared impressive hair regrowth results after using 1mg finasteride daily for over a year, with minimal side effects. The user also mentioned taking biotin gummies and experiencing periods of shedding followed by thicker hair growth.
The conversation is about someone's hair growth progress after two months of daily treatment with 1 mg finasteride and 1.25 mg oral minoxidil. The replies are positive and encouraging.
TDM-105795 showed promising hair growth results, with higher efficacy than placebo and minimal side effects. It activates dormant hair follicle stem cells and may maintain gains without immediate loss, unlike minoxidil.
Young men experiencing hair loss are frustrated with advice to embrace baldness without exploring treatments. They advocate for using finasteride and minoxidil, considering hair transplants, and hope for future advancements in hair restoration.
A user documented their two-year hair regrowth journey using finasteride, minoxidil, and derma rolling, showing significant improvement. They switched from topical to oral minoxidil after the first year, experiencing some shedding and minor bloating.
The user discovered their previous hair loss medication was counterfeit and switched to Propecia, which significantly lowered their DHT levels. They plan to continue using Propecia and add oral Minoxidil to their routine for better results.
A user shared their hair regrowth journey from ages 31 to 39, using finasteride, oral and topical minoxidil, and dutasteride. They experienced significant hair density improvement and temple regrowth, with increased hair growth as the only side effect.
A 28-year-old male shares progress on hair loss treatment using 0.5mg dutasteride and 5mg minoxidil, experiencing initial shedding but encouraged by community support. He also uses ketoconazole occasionally based on scalp oiliness.
PP405 may help with hair regrowth, especially when combined with minoxidil and finasteride, but its long-term effectiveness is unclear. Phase 3 trials are expected to begin soon, with results in a few years.
The user is considering using topical finasteride for thinning hair around the middle part, vertex, and crown, and is unsure if the whole scalp is thinning. Another user suggests oral finasteride is more effective than topical, and recommends consulting a dermatologist for proper treatment.
A 22-year-old male experienced hair thinning and found minoxidil ineffective, with blood tests showing deficiencies in zinc, vitamin B12, vitamin D3, and possible hypothyroidism. Another user suggested adding topical finasteride to the regimen, which helped them regrow hair effectively without side effects.
Finasteride stopped scalp itching and improved hair health, likely due to reduced DHT. Users discussed the relationship between DHT, itching, and hair loss, with some mentioning minoxidil and antifungal treatments like ketoconazole.
The user is using Dutasteride and oral Minoxidil for hair regrowth and is considering adding topical Minoxidil but is allergic to propylene glycol, which is present in the product they found. They need a solution with tretinoin that does not contain propylene glycol.
Dutasteride and oral minoxidil significantly improved hair appearance, with noticeable changes in color and texture. The user experienced minimal side effects and attributes most progress to dutasteride.
A new hair loss treatment, KX-826, is being discussed as a stronger and safer alternative to RU58841 and finasteride. Opinions are mixed, with some users skeptical about its effectiveness and others considering it as part of their regimen.
A 20-year-old with diffuse hair thinning has been using finasteride daily for 2 years and added topical minoxidil once daily at night for the past 7.5 months, seeing improved results. They are switching to oral minoxidil for convenience and will update on the outcome.
A user discussed a significant hair recovery using alfatradiol and fluridil but was considered untrustworthy and the post was deleted. They are seeking the original poster's username.
Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.
A user reported hair thickening and a stronger crown after using rosemary shampoo for about a year, with progress pictures as evidence. Some commenters discussed the effectiveness of natural treatments versus pharmaceutical options like Minoxidil and Finasteride.
Rosemary water's effectiveness for hair growth is debated, with some users suggesting medications like minoxidil combined with tretinoin for better results. Others argue rosemary oil may work with continuous use, but evidence is questioned.
A 35-year-old has seen no hair regrowth after 9 months using treatments including finasteride, pyrilutamide, microneedling, ketoconazole shampoo, and topical dutasteride, but experienced side effects with RU58841. Commenters suggest starting minoxidil for better results and question why it wasn't included from the beginning.