Finasteride and dutasteride are discussed as preventative treatments for hairloss, with some advocating for early use and others concerned about side effects, especially before full maturity. Many regret not starting these treatments earlier due to their effectiveness in preventing or slowing hairloss.
Creatine is believed by some to cause hairloss, potentially by increasing DHT levels, despite conflicting evidence. Users report mixed results when combining creatine with treatments like finasteride, dutasteride, and minoxidil.
PP405, a potential hairloss treatment, is facing delays in releasing Phase 2 results, causing frustration among users who compare it to past failed treatments. Despite skepticism, some remain hopeful about PP405's future, while others discuss alternative treatments like Clascoterone and its expected market release.
Concerns about the potential high cost of new hairloss treatments, pp405 and gt20029, were discussed, with some users willing to pay a premium if they are effective. Alternatives like finasteride and minoxidil are mentioned as current, more affordable options, and there is speculation about future generic versions and black market availability.
Starting finasteride, dutasteride, and minoxidil early is advised for minimal hairloss to preserve hair. Professional consultation is important due to potential side effects.
GT20029 is a topical treatment that degrades androgen receptors to prevent hair thinning and loss, potentially offering fewer side effects than systemic treatments like finasteride. Concerns include its impact on hair texture and potential systemic effects, with market availability speculated in 3 to 5 years.
Minoxidil alone is often insufficient for treating hairloss because it doesn't address the DHT-related cause. Combining it with finasteride, a DHT blocker, is generally more effective.
There have been no new effective hairloss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.
In the Czech Republic, doctors are largely unaware of hairloss treatments beyond minoxidil, and finasteride is hard to obtain. Many users suggest buying treatments like finasteride and minoxidil from other countries or online.
Many celebrities and athletes likely use hairloss treatments like Minoxidil and Finasteride. Despite their effectiveness, only a small percentage of the general population uses these treatments.
Sugary beverages increase the risk of pattern hairloss in men by 57%, and type 2 diabetes is linked to female pattern hairloss. Reducing sugar intake and using treatments like finasteride and minoxidil may help manage hairloss.
The conversation discusses whether whey protein and creatine worsen hairloss. Some users report hairloss with creatine use, while others do not; opinions on whey protein's effects are mixed. Treatments mentioned include PRP, minoxidil, and finasteride.
The conversation suggests that changing diet and lifestyle has little to no effect on male pattern baldness (MPB), which is largely determined by genetics. Some individuals noted personal improvements in hair condition with healthier diets, but the consensus is that diet alone cannot prevent or reverse MPB.
User started finasteride at 18, added minoxidil later but stopped due to side effects. Hairloss continued despite treatments, considering dutasteride but hesitant. Others suggest trying dutasteride and discussing with a dermatologist.
Creatine is reported to cause increased hair shedding, but there is no scientific evidence linking it to hairloss. Some users manage hairloss with finasteride and minoxidil or consider stopping creatine if shedding worsens.
The conversation discusses skepticism about the effectiveness of new hairloss treatments, mentioning that despite 40 years of research, only accidental discoveries like Minoxidil and Finasteride have been made. It also notes that drug development is a slow process, often taking a decade or more to bring a new drug to market.
There is no natural way to stop hairloss; pharmaceuticals like minoxidil, finasteride, and RU58841 are the only effective treatments. Some users report success with minoxidil and microneedling, while others discuss the side effects of finasteride.
Clascoterone lotion, being tested in Germany, is as effective as Minoxidil and Finasteride for hairloss but without serious side effects. About 400 men participated in the trials.
Celebrities opening up about their hairloss and the various treatments they are using to address it, including finasteride, dutasteride, and hair transplants, as well as the stigma surrounding male pattern baldness in Hollywood.
The conversation discusses the role of DHT in male hairloss and the effectiveness of treatments like Finasteride, which reduces DHT, and RU58841, which blocks DHT from binding to scalp receptors. The user debates the trade-offs between maintaining hair and having a healthy endocrine system, suggesting RU58841 might allow for both.
The FDA policy change may speed up approval for hairloss drugs like PP405, VDPHL-01, and Breezula by potentially eliminating the need for a second confirmatory Phase 3 trial. Approval timelines could be as early as 2028 for some treatments if Phase 3 results are strong.
GT20029 is discussed as a potential treatment for androgenetic hairloss by targeting androgen receptors, unlike finasteride which reduces DHT broadly. Concerns include its effectiveness, genetic variations in androgen receptors, and availability, with some skepticism about its potential as a true alternative.
Creatine does not increase DHT levels or cause hairloss. Personal experiences vary, but scientific evidence shows no link between creatine and hairloss.
AMP-303, a new injectable treatment for androgenetic alopecia, showed promising results in increasing hair count and density with minimal side effects. The treatment demonstrated significant hair regrowth and durability, offering new hope for those with hairloss.
The user is using finasteride and minoxidil for hairloss but is looking for new treatments. Pyrilutamide and GT20029 are potential future treatments, with Pyrilutamide expected next year and GT20029 possibly by 2027.
The post discusses frustration over the limited and not always effective treatments for hairloss, mainly Minoxidil and Finasteride. The conversation includes mentions of potential new treatments like GT20029, HMI-115, CosmeRNA, KX-826, and microneedling, but also highlights the challenges of funding and prioritizing research in this area.
The importance of patience when using treatments for hairloss, such as finasteride, minoxidil and RU58841, which can take 6-12 months to show results, sometimes causing initial hairloss. Everyone's experience is different, so it may take time to find what works best.