PRP is not a cure for baldness but can support hairgrowth, though it requires ongoing sessions and is costly. Minoxidil and Finasteride are commonly used treatments, but results vary.
Veradermics' phase 2 trial of slow-release oral minoxidil shows promisinghair regrowth with minimized side effects, gaining significant attention and funding. PP405 is also noted for its potential as a side-effect-free alternative.
Microneedling with minoxidil significantly boosts hairgrowth, even for non-responders to minoxidil alone. The routine includes a 1.5mm dermaroller weekly and minoxidil twice daily, with some users adding finasteride and tretinoin.
Cyclosporine A is discussed as a powerful hairgrowth stimulant, potentially more effective than minoxidil, but concerns about safety and side effects, including cancer risk, limit its use. The conversation highlights the need for further research and experimentation with topical application, despite its risks.
The user started hair loss treatment on June 26th using 1.25mg finasteride, 1ml 5% minoxidil twice a day, derma rolling every 1.5 weeks, and 2% ketoconazole foam twice a week. They experienced significant hairgrowth in the first four months, with thicker hair and improved hairline, but had a rough shedding phase in November.
User started minoxidil and microneedling for hairgrowth and saw amazing results, but recently experienced hair thinning again. Others suggest adding finasteride, but user is hesitant and has difficulty obtaining it.
Research and science related to a minor improvement in hairgrowth caused by the use of verteporfin, as well as potential treatments such as Minoxidil, Finasteride, and RU58841.
PP405 is considered a promising potential cure for hair loss, with phase 2 trial results expected in February 2025. Hair cloning is also discussed as a potential ultimate solution, despite significant scientific challenges.
Safflower oil is suggested as an alternative to minoxidil for hairgrowth, with benefits including scalp conditioning and hair strength enhancement. Studies indicate it may also reverse scalp dermatitis, alopecia, and prevent premature grayness.
Dutasteride is more effective than finasteride for some in stopping hair loss and promoting regrowth, with fewer side effects. Oral minoxidil is also used for regrowth, but there are safety concerns, especially for younger users.
A user is trying 2-deoxy-D-ribose with distilled water for hairgrowth, observing new hair and skin pigmentation changes. Others compare it to Minoxidil, expressing interest and caution about its effectiveness and safety.
Peppermint oil at 3% was found to improve hairgrowth more effectively than Minoxidil. The user is also using a topical caffeine hairgrowth oil and making their own peppermint solution to combat hair thinning.
A female with suspected hair loss is considering using vitamins, a dermaroller, and essential oils to stimulate hairgrowth. Advice includes choosing a dermaroller with needles, preferably stainless steel.
TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hairgrowth and reduce hair follicle sensitivity to DHT.
The user is considering alternatives to topical minoxidil for hairgrowth due to concerns about future cat ownership, mentioning stemoxydine and redensyl as possibilities. They currently use topical regaine foam and oral finasteride.
Combining microneedling with Low Level Laser Therapy (LLLT) for hairgrowth, with discussions on device legitimacy and effectiveness. Alternatives like PEMF and the use of oral and topical treatments such as dutasteride, minoxidil, and finasteride are also considered.
The user added melatonin to their 5% minoxidil solution for hairgrowth, using a concentration of 0.0033%, which equates to roughly 2mg for a 60ml bottle. They later reported no significant difference and planned to continue the treatment for a few more months before potentially stopping to observe any changes in shedding.
The conversation discusses the potential positive effects of melatonin on hairgrowth. The original poster plans to try both oral and topical melatonin and is seeking recommendations for a good source.
The conversation discusses difficulty in distinguishing between new hairgrowth and thinning hair at the temples after using microneedling and a rosemary peppermint topical for four weeks. The advice given is to wait a few months to see if the hairs grow out to determine their nature.
Hair loss treatments discussed include Minoxidil, Finasteride, and RU58841. Anageninc stopped selling KX-826 (Pyrilutamide) due to a cease and desist letter from Kintor, but this may indicate promising study results and a potential 2024 release.
Collagen peptides are recommended for hair and skin benefits, with users noting improvements in hair and skin health. However, evidence on their effectiveness for hairgrowth is inconclusive.
Microneedling may enhance hair regrowth by transferring stem cells to dormant follicles, improving the effects of minoxidil. Users discuss using microneedling with needle lengths around 1.5mm to stimulate hairgrowth.
Low-Level Laser Therapy (LLLT) is seen as a safe and effective method for maintaining hair and promoting regrowth in androgenetic alopecia (AGA) and male pattern baldness (MPB), with devices like the HairMax LaserComb® and iRestore helmet being popular. Some users and professionals are skeptical about its long-term effectiveness and cost.
Rob English, known for promoting scalp massages for hair regrowth, now sells his own brand of finasteride and minoxidil. Opinions are mixed, with some calling him a charlatan and others acknowledging his shift towards scientifically-backed treatments.
Pelage Pharmaceuticals' PP405 aims to treat hair loss by reactivating dormant hair follicle stem cells, showing promising results in early trials. The company plans to present their findings at the American Academy of Dermatology Annual Meeting in 2026.
KX-826 (Pyrilutamide) 0.5% and 1.0% solutions showed promising results in increasing hair count for male androgenetic alopecia, with the 0.5% dose slightly outperforming the 1% dose. The treatment was well-tolerated with no sexual side effects, but skepticism remains due to past inconsistencies in trial results.
Travoprost may be more effective than minoxidil for hairgrowth and can be used alongside it, but its effectiveness is debated due to inconsistent dosing results. Travoprost is expensive and not widely used, with alternatives like latanoprost and bimatoprost being more accessible.
A hair loss treatment plan includes finasteride, dutasteride, RU58841, pyrilutamide, minoxidil, and microneedling to inhibit DHT and promote hairgrowth. It also recommends supplements like Reishi and Lion’s Mane mushrooms, and a shampoo with ketoconazole, caffeine, and melatonin.
Follicopeptide (FOL005) by Coegin Pharma will launch as a cosmetic hairgrowth treatment by Q2 2025, showing similar efficacy to finasteride. Users discuss the benefits and skepticism of releasing hair loss treatments as cosmetics rather than drugs.