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      community Hormones and hair loss (23F)

       6 upvotes 9 years ago
      The user is experiencing severe hair loss, possibly due to telogen effluvium, after stress, poor nutrition, and hormonal changes. They are using Nizoral and supplements but are considering hormonal treatments like spironolactone despite previous side effects.

      community Full extent of pp405 effectiveness

      in Treatment  14 upvotes 5 months ago
      The conversation discusses the potential effectiveness and future results of the hair loss treatment pp405, with questions about its impact on different hair loss stages and areas. There is anticipation for phase 3 trial results to provide more data, and hope that pp405 could enhance hair transplant outcomes.

      community GHK Cu - is this the next best solution for hairloss?

      in Research/Science  20 upvotes 2 months ago
      GHK-Cu is discussed as a potential hair loss treatment, with claims of promoting hair growth and possibly reversing gray hair, though strong clinical evidence is limited. The user also mentions using Minoxidil, red light therapy, and microneedling.

      community PP405 - A True Breakthrough or Another Disappointment?

      in Research/Science  32 upvotes 9 months ago
      PP405 shows potential for hair growth, with 31% of advanced balding men experiencing over 20% increase in hair density in 8 weeks. However, skepticism persists due to selective data presentation and lack of long-term results, with comparisons to treatments like minoxidil and finasteride.

      community Any other non-responders to most medications?

      in Finasteride/Dutasteride  5 upvotes 2 years ago
      The user has not seen results from various hair loss treatments including finasteride, dutasteride, minoxidil, and others over several years and is considering adding RU58841 and starting hormone replacement therapy. They are also experiencing anxiety and contemplating moving to a more accepting environment for their nonbinary identity.

      community CRISPR treatment for AGA on the horizon after approval for blood disorders

      in Treatment  9 upvotes 2 years ago
      CRISPR treatments for blood disorders have been approved, leading to discussions about its potential for treating hair loss (AGA). A study showed that editing a gene related to DHT sensitivity could lead to hair regrowth, suggesting CRISPR may eventually be used for AGA, but it's expected to be expensive and not soon available.

      community Twist1 Group Buy: Yes it’s that easy

      in Research/Science  39 upvotes 3 years ago
      A group buy for testing a compound targeting Twist1 protein as a potential hair loss treatment. Inhibiting Twist1, which keeps hair follicles in growth phase, may prevent hair loss with minimal side effects.

      community Post Low-Level Laser Light Therapy Syndrome (PLLLTS )

      in Satire  6 upvotes 2 years ago
      Hair loss discussion includes LLLT treatments and a satirical condition called PLLLTS, causing patients to resemble lighthouses and attract moths. Some users express concern about others taking the satire seriously.

      community Now i want to see if this DHT survives

      in Treatment  33 upvotes 9 months ago
      The conversation discusses using minoxidil, finasteride, spironolactone, and RU58841 for hair loss treatment. Users share experiences with these treatments, noting side effects and varying effectiveness.

      community Shiseido RCH-01

       7 upvotes 7 years ago
      Shiseido RCH-01 and Replicel's upcoming trial data release. Users discuss expected release timelines and clarify quarter dates.

      community The mechanism of androgenic alopecia

      in Research/Science  33 upvotes 6 months ago
      DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

      community Crazy Shed After Starting Hair Treatment

      in Finasteride/Dutasteride  5 upvotes 1 year ago
      The user experienced significant hair shedding after starting finasteride, RU58841, and topical minoxidil. They increased their finasteride dosage and added dutasteride, seeking advice on whether this reaction is normal and its duration.

      community Insane regression after hyper-responding (17M) AMA

      in Progress Pictures  137 upvotes 1 year ago
      A 17-year-old experienced significant hair loss after switching from topical to oral minoxidil and adding finasteride. The recommendation is to return to topical minoxidil and continue with finasteride or consider dutasteride.

      community Replicel, worthy of hype or probable disappointment? Questions thread

       4 upvotes 9 years ago
      The conversation discusses the potential of Replicel/Shiseido treatment for hair loss, questioning its effectiveness, whether it grows new follicles, and its market release timeline. It also compares Replicel to other competitors like Kyocera/RIKEN/Tsuji.

      community Will we ever hear about HMI -115

      in Update  20 upvotes 2 years ago
      Hair loss discussion includes treatments Minoxidil, Finasteride, and RU58841. Update on HMI-115 clinical trial expected in July or August.

      community Any chemists want to manufacture PP405 / JXL069? (Steps inside)

      in Research/Science  88 upvotes 5 months ago
      The conversation discusses the synthesis and potential use of JXL069 and PP405 for hair loss treatment, with skepticism about their effectiveness and concerns about safety. Users mention that JXL069 has shown no results in hair growth, and there is confusion about its identity and effectiveness compared to PP405.

      community PTD-DBM Update: Q&A With Dr. Kang-Yell Choi

      in Treatment  14 upvotes 6 years ago
      PTD-DBM is being explored for hair regrowth by targeting CXXC5, with clinical trials expected after pre-clinical studies. Users express anticipation and skepticism about its effectiveness.

      community Extreme growth from only vitamins!

      in Update  63 upvotes 1 year ago
      A user experienced significant hair regrowth after improving their diet, getting sunlight, taking a multivitamin, and exercising, following a period of extreme calorie restriction and hair shedding. Others in the conversation attribute the hair regrowth to increased calorie intake rather than just vitamins.